Article
Psychiatry
En Zhang, Zhongfei Huang, Zongjun Zang, Xin Qiao, Jiaxin Yan, Xuefei Shao
Summary: This study aimed to explore circulating biomarkers for the diagnosis of major depressive disorder (MDD). Six characteristic proteins were identified and showed high diagnostic value in discriminating MDD patients from healthy controls. Additionally, these proteins were found to be associated with the severity of depressive symptoms.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Ka Young Kim, Ki Young Shin, Keun-A Chang
Summary: This study focused on major depressive disorder (MDD) and identified potential inflammatory biomarkers associated with suicidal risk. The findings highlighted the significant alterations in peripheral inflammatory factors in MDD patients with suicide-related behaviors, indicating the potential roles of specific biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Caroline Swoboda, Lena Deloch, Claudia von Zimmermann, Tanja Richter-Schmidinger, Bernd Lenz, Johannes Kornhuber, Christiane Muehle
Summary: This study investigated the potential of MIF at genetic, expression, and protein levels as a risk factor and biomarker for diagnosing, monitoring, or predicting MDD. The results suggest a genetic effect of MIF in women but do not provide strong evidence for its utility as a biomarker for MDD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Hyebin Choi, Sora Mun, Eun-Jeong Joo, Kyu Young Lee, Hee-Gyoo Kang, Jiyeong Lee
Summary: A proteomic study identified prothrombin as a potential biomarker for MDD, showing significantly increased levels in depressive patients and its association with platelet hyper-activation. This suggests prothrombin could be used for screening, prognosis, and diagnosis of MDD.
Article
Neurosciences
Shaoli Li, Duo Lv, Chao Qian, Jiajun Jiang, Peifen Zhang, Caixi Xi, Lingling Wu, Xingle Gao, Yaoyang Fu, Danhua Zhang, Yiqing Chen, Huimin Huang, Yiyi Zhu, Xiaorong Wang, Jianbo Lai, Shaohua Hu
Summary: Peripheral T-cell subsets may serve as a biomarker to differentiate major depressive disorder (MDD) and bipolar disorder (BD). Significant differences were found in CD3+, CD4+, CD8+ T-cell, and natural killer (NK) cell proportions among patients with MDD, BD mania, and BD depression (BD-D). The random forest model showed good performance in distinguishing BD-D from MDD patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Psychiatry
Ying Li, Yan Gui, Miaomiao Zhao, Xuanqiang Chen, Haimei Li, Chen Tian, Haoyang Zhao, Chaonan Jiang, Pengfeng Xu, Shiyi Zhang, Shaoyong Ye, Manli Huang
Summary: This article discusses the role of extracellular vesicles (EVs) in major depressive disorder (MDD) and highlights their potential as biomarkers, therapeutic indicators, and drug delivery carriers for the treatment of MDD.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Petra Steinacker, M. H. D. Rami Al Shweiki, Patrick Oeckl, Heiko Graf, Albert C. Ludolph, Carlos Schonfeldt-Lecuona, Markus Otto
Summary: This study suggests that serum GFAP levels could enhance the differential diagnosis of MDD and could be used to objectively quantify depression severity, with levels increasing with age and MDD severity. The levels of serum GFAP are independent of neurodegeneration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Nutrition & Dietetics
Veronique Bernier, Marie-Helene Debarge, Matthieu Hein, Sarah Ammendola, Anais Mungo, Gwenole Loas
Summary: This study shows that the diet of patients with major depressive disorder (MDD) is often a Western diet high in fat and sugar, which is associated with inflammation. Blood analysis of MDD patients revealed higher levels of C-reactive protein (CRP), indicating inflammation, and also showed correlations between nutritional factors and CRP. These findings highlight the importance of diet in MDD and suggest a potential role of diet in sustaining the inflammatory state.
Review
Biochemistry & Molecular Biology
Miguel A. Ortega, Miguel Angel Alvarez-Mon, Cielo Garcia-Montero, Oscar Fraile-Martinez, Guillermo Lahera, Jorge Monserrat, Luis Munoz-Merida, Fernando Mora, Roberto Rodriguez-Jimenez, Sonia Fernandez-Rojo, Javier Quintero, Melchor Alvarez-Mon
Summary: miRNAs play a key role in the pathophysiology of Major Depressive Disorder and could serve as potential biomarkers. Lifestyle interventions such as physical activity, mindfulness, and diet are also important considerations.
Review
Oncology
Ziqi Chen, Xiaoqi Huang, Qiyong Gong, Bharat B. Biswal
Summary: Advancements in neuroimaging have led to the detection of numerous brain functional and structural alterations in MDD, with attempts to apply these findings to clinical practice. While evidence of cerebral changes related to MDD classification and subtyping is varied, the ACC and hippocampus are consistently suggested as important biomarkers for treatment selection and response prediction. This highlights the potential utility of brain biomarkers in clinical practice.
FRONTIERS OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sliha Awan, Aisha N. Hashmi, Rizwan Taj, Sadaf Munir, Rabia Habib, Sajida Batool, Maleeha Azam, Raheel Qamar, Syed M. Nurulain
Summary: The study investigated the role of butyrylcholinesterase (BChE) in major depressive disorder (MDD) and found a significant decrease in BChE activity in MDD patients compared to healthy controls. Genetic polymorphisms in the BCHE gene, particularly rs1803274, were associated with MDD, with varying effects observed in different genders. Further replication studies in diverse ethnic groups are recommended to validate these findings.
BIOCHEMICAL GENETICS
(2022)
Article
Psychology, Clinical
Wenfan Gao, Yayun Xu, Jun Liang, Yanhong Sun, Yuanyuan Zhang, Feng Shan, Jinfang Ge, Qingrong Xia
Summary: This study examined the serum levels of CC chemokines in patients with major depressive disorder (MDD) and found that MIP-1 alpha and MIP-113 were higher in MDD patients while MCP-1, MCP-4, TARC, MDC, and Eotaxin-3 were lower compared to controls. The ROC curve analysis showed that MIP-1 alpha, MCP-4, TARC, and Eotaxin-3 had good discriminatory value in identifying MDD patients.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2022)
Article
Immunology
David Mongan, Subash Raj Susai, Melanie Focking, Jonah F. Byrne, Stan Zammit, Mary Cannon, David R. Cotter
Summary: This study found associations between mental disorders and chronic inflammatory markers, particularly soluble urokinase plasminogen activator receptor (suPAR), in young adults aged 24. The study also confirmed associations between inflammatory markers and psychiatric co-morbidity.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Psychiatry
Yu Zhang, Lei Lei, Ziwei Liu, Mingxue Gao, Zhifen Liu, Ning Sun, Chunxia Yang, Aixia Zhang, Yikun Wang, Kerang Zhang
Summary: This study investigated the differences in EEG power spectrum at theta oscillations between patients with MDD and patients with AN. It found that AN patients demonstrated reduced power in the prefrontal cortex, left temporal lobe, and right occipital regions compared to MDD patients.Theta oscillations could potentially serve as a biomarker that distinguishes MDD from AN, pending further confirmation in future studies.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemical Research Methods
Van-An Duong, Jeeyun Ahn, Na-Young Han, Jong-Moon Park, Jeong-Hun Mok, Tae Wan Kim, Hookeun Lee
Summary: This study characterized the proteomes of PDR and NPDR in diabetic retinopathy through quantitative analysis. Specific proteins associated with PDR and NPDR were identified as potential biomarkers, indicating potential new treatment options for earlier stages of DR.
CURRENT PROTEOMICS
(2021)
Article
Chemistry, Multidisciplinary
Yu Ri Choi, Kwang Sung Kim, Raju Bandu, Hyoseon Kim, Jae Eun Lee, Byong-Kyu Shin, Yang Je Cho, Jong Moon Park, Hookeun Lee, Kwang Pyo Kim
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2020)
Article
Biotechnology & Applied Microbiology
YuJin Noh, Hwanhui Lee, Seong-Joo Hong, Hookeun Lee, Byung-Kwan Cho, Choul-Gyun Lee, Hyung-Kyoon Choi
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
(2020)
Article
Endocrinology & Metabolism
Eu Jeong Ku, Kyung-Cho Cho, Cheong Lim, Jeong Won Kang, Jae Won Oh, Yu Ri Choi, Jong-Moon Park, Na-Young Han, Jong Jin Oh, Tae Jung Oh, Hak Chul Jang, Hookeun Lee, Kwang Pyo Kim, Sung Hee Choi
BMJ OPEN DIABETES RESEARCH & CARE
(2020)
Article
Biochemistry & Molecular Biology
Goyeun Yun, Jong-Moon Park, Van-An Duong, Jeong-Hun Mok, Jongho Jeon, Onyou Nam, Joonwon Lee, EonSeon Jin, Hookeun Lee
Article
Biochemical Research Methods
Jong-Moon Park, Van-An Duong, Jeong-Hun Mok, Doo-Jin Choi, Hookeun Lee
Summary: This study aimed to quantitatively analyze proteomic changes in neural cells exposed to H2O2 and treated with N-acetylcysteine (NAC). The findings confirmed the cytoprotective effects of NAC on neural cells against oxidative stress, as evidenced by cell viability studies and lactate dehydrogenase assays. The proteomic analysis identified differentially expressed proteins involved in the protective mechanisms of NAC against H2O2-induced toxicity.
CURRENT PROTEOMICS
(2021)
Article
Engineering, Marine
Dami Kwon, Jong-Moon Park, Van-An Duong, Seong-Joo Hong, Byung-Kwan Cho, Choul-Gyun Lee, Hyung-Kyoon Choi, Dong-Myung Kim, Hookeun Lee
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2020)
Review
Microbiology
Yujin Jeong, Sang-Hyeok Cho, Hookeun Lee, Hyung-Kyoon Choi, Dong-Myung Kim, Choul-Gyun Lee, Suhyung Cho, Byung-Kwan Cho
Article
Biochemistry & Molecular Biology
YuJin Noh, Hwanhui Lee, Myeongsun Kim, Seong-Joo Hong, Hookeun Lee, Dong-Myung Kim, Byung-Kwan Cho, Choul-Gyun Lee, Hyung-Kyoon Choi
Summary: The study examined the effects of exogenous glucose on Synechocystis 7338 in terms of cell growth, pigments, metabolites, and lipids, showing that glucose supplementation can increase cell growth and production, making it a promising strategy for industrial applications.
Article
Biochemistry & Molecular Biology
Van-An Duong, Onyou Nam, EonSeon Jin, Jong-Moon Park, Hookeun Lee
Summary: Emiliania huxleyi, a cosmopolitan coccolithophore, was studied for the global discovery of post-translational modifications (PTMs) using a three-dimensional separation method combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Methylation was found to be the most frequent PTM, with lysine being the most frequently modified amino acid. The number of identified proteins increased by 22.5% after the PTM search, with some proteins showing a significant increase in intensity.
Review
Chemistry, Multidisciplinary
Van-An Duong, Jong-Moon Park, Hee-Joung Lim, Hookeun Lee
Summary: Proteomics, a powerful tool for studying biological systems, can provide a holistic view of physiological and biochemical states of samples. It is highly valuable in forensic science and can provide a better global picture of a sample compared to genomic analysis.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Jeong-Hun Mok, Minjoong Joo, Van-An Duong, Seonghyeon Cho, Jong-Moon Park, Young-Sic Eom, Tae-Hwa Song, Hee-Joung Lim, Hookeun Lee
Summary: In this study, maggots collected from pig carcasses were analyzed using an integrated proteomics and metabolomics approach to determine candidate substances for estimating post-mortem interval (PMI). The data revealed changes in specific metabolites during maggot development, providing valuable insights for PMI estimation in forensic science. Additionally, this research demonstrated the feasibility of directly and indirectly profiling proteome and metabolome in forensic investigations.
APPLIED SCIENCES-BASEL
(2021)
Review
Chemistry, Analytical
Van-An Duong, Jong-Moon Park, Hookeun Lee
Summary: The bottom-up proteomic workflow comprises of sample preparation, data acquisition, and data analysis. Sample preparation has remained a challenge, but new methods such as suspension trapping digestion have shown promising results. Suspension trapping digestion is a simple, rapid, and reproducible method that can handle low microgram or sub-microgram amounts of proteins.
JOURNAL OF SEPARATION SCIENCE
(2022)
Article
Chemistry, Analytical
Hey Gene Lee, MinJoong Joo, Jong-Moon Park, Mi Ae Kim, JeongHun Mok, Seong-Hyeon Cho, Young Chang Sohn, Hookeun Lee
Summary: In this study, untargeted lipid profiling of Pacific abalone tissues and hemolymph was conducted using ultrahigh-performance liquid chromatography-tandem mass spectrometry. The results revealed variations in lipid components at different developmental stages, with triglycerides and phosphatidylcholines being the major lipids identified. Lysophosphatidylcholine was only detected in the tissues of mature abalones. These findings provide valuable insights into the lipidome of abalone tissues and hemolymph, laying the foundation for improving the efficiency and quality of abalone aquaculture.
JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Van-An Duong, Hookeun Lee
Summary: Liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomics is a powerful technique for analyzing cellular, tissue, and fluid proteomes. While LC-MS/MS and data analysis techniques have been well-developed, sample preparation remains a challenging and laborious process. In this review, various methods for sample preparation in proteomics, as well as devices and methods for integrating different steps of sample preparation and peptide fractionation, are outlined and discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)