Journal
KIDNEY INTERNATIONAL
Volume 86, Issue 1, Pages 9-10Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ki.2014.22
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Funding
- NIDDK NIH HHS [K01-DK095018, K01 DK095018] Funding Source: Medline
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The signal transduction mechanisms involved in the renoprotective effects of relaxin are not well understood. Chow et al. demonstrate that relaxin family peptide receptor 1 (RXFP1) forms heterodimer complexes with the angiotensin type 2 receptor (AT(2)), even in the absence of ligand, and that these heterodimers are required for relaxin's antifibrotic effects. These findings identify a previously unknown link between relaxin and angiotensin II signaling that could be a potential new target for slowing the progression of fibrotic renal diseases.
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