Article
Pharmacology & Pharmacy
Priyal Patel, Sandip Patel, Piyush Chudasama, Shailesh Soni, Manan Raval
Summary: The present investigation explored the potential treatment option of roflumilast as a PDE4 inhibitor for chronic kidney disease. The results demonstrated that roflumilast significantly reduced serum creatinine, urea, uric acid levels, increased serum calcium, and regulated protein expression of inflammatory markers. Moreover, roflumilast noticeably improved the structure and functioning of glomeruli, tubules, and cells. Therefore, roflumilast has the potential to ameliorate renal injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fatimah K. Khalaf, Chrysan J. Mohammed, Prabhatchandra Dube, Jacob A. Connolly, Apurva Lad, Usman M. Ashraf, Joshua D. Breidenbach, Robin C. Su, Andrew L. Kleinhenz, Deepak Malhotra, Amira F. Gohara, Steven T. Haller, David J. Kennedy
Summary: This study found that decreased PON-1 is associated with the progression of renal inflammation and fibrosis independent of blood pressure. By knockout of the Pon1 gene in a rat model, it was discovered that the absence of PON-1 leads to increased renal fibrosis, sclerosis, and tubular injury, as well as increased recruitment of immune cells in the renal interstitium and the expression of inflammatory genes. Furthermore, the absence of PON-1 also results in a decline in renal function and increased renal oxidative stress.
Review
Medicine, General & Internal
Bin Wang, Zuo-Lin Li, Yi-Lin Zhang, Yi Wen, Yue-Ming Gao, Bi-Cheng Liu
Summary: This review outlines the characteristics, mechanisms, complications, potential therapeutic approaches, and challenges of chronic hypoxia in chronic kidney disease (CKD).
Article
Medical Laboratory Technology
Evan Paul Owens, Helen Grania Healy, David Alan Vesey, Wendy Elizabeth Hoy, Glenda Carolyn Gobe
Summary: This article reviews new and emerging biomarkers for the development and progression of chronic kidney disease (CKD), which can be detected in blood or urine liquid biopsies. These biomarkers play important roles in kidney injury, inflammation, oxidative stress, repair, and fibrosis. However, there are conflicting conclusions regarding the utility of these biomarkers in CKD.
CLINICA CHIMICA ACTA
(2022)
Article
Physiology
Roberto Palacios-Ramirez, Ixchel Lima-Posada, Benjamin Bonnard, Marie Genty, Amaya Fernandez-Celis, Judith Hartleib-Geschwindner, Fabienne Foufelle, Natalia Lopez-Andres, Krister Bamberg, Frederic Jaisser
Summary: Obesity and metabolic diseases are linked to chronic kidney disease, and mineralocorticoid receptor antagonists have shown potential in treating non-diabetic chronic kidney disease associated with metabolic diseases. This study used a mouse model to demonstrate the beneficial effects of the mineralocorticoid receptor antagonist canrenoate in improving metabolic function and reducing proteinuria in chronic kidney disease mice, while also preventing the detrimental effects of a high fat diet on renal fibrosis and inflammation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Huiqi Yuan, Chaoyang Zheng, Li Zhu, Ziqing Song, Linfeng Dai, Qingzong Hu, Lei Wang, Yang Chen, Jing Xiong
Summary: TFEB-mediated autophagy plays a crucial role in the pathogenesis of chronic kidney disease, leading to tubulointerstitial injury and renal fibrosis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, General & Internal
Amir Shabaka, Clara Cases-Corona, Gema Fernandez-Juarez
Summary: CKD has a significant impact on global morbidity and mortality through its effects on cardiovascular risk and end-stage kidney disease. Optimal management strategies for CKD include blood pressure control, treatment of albuminuria, avoidance of nephrotoxins and obesity, as well as new antihyperglycemic drugs and potassium-lowering therapies. Research efforts are now focusing on unraveling early disease mechanisms and developing novel therapeutic approaches targeting various aspects of CKD progression.
FRONTIERS IN MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Jonatan Barrera-Chimal, Frederic Jaisser, Hans-Joachim Anders
Summary: Chronic kidney disease is a major public health concern globally, with MR antagonists emerging as a potential therapeutic approach against various forms of kidney disease. Experimental and clinical studies have shown the protective effects of MRAs in reducing albuminuria and slowing disease progression. Recent evidence also suggests that MRAs can reduce hard kidney outcomes, particularly in CKD associated with type 2 diabetes, highlighting their potential benefit in maximizing organ protection through combination therapy.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Philip Chiu-Tsun Tang, Alex Siu-Wing Chan, Cai-Bin Zhang, Cristina Alexandra Garcia Cordoba, Ying-Ying Zhang, Ka-Fai To, Kam-Tong Leung, Hui-Yao Lan, Patrick Ming-Kuen Tang
Summary: Chronic kidney disease (CKD) is a major global health issue with complex pathogenic mechanisms and currently lacks effective therapeutic strategies. Immune cell dysfunction leads to inflammation and fibrosis, with TGF-beta 1 playing a critical role in promoting CKD progression.
FRONTIERS IN MEDICINE
(2021)
Review
Immunology
Sarah Cormican, Matthew D. Griffin
Summary: Innate immune cells play a key role in kidney inflammation and fibrosis, with the CX3CL1-CX3CR1 signaling pathway being closely linked to acute and chronic kidney diseases. Targeting this pathway may offer potential benefits for patients with CKD.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Takahiko Nakagawa, Laura G. Sanchez-Lozada, Ana Andres-Hernando, Hideto Kojima, Masato Kasahara, Bernardo Rodriguez-Iturbe, Petter Bjornstad, Miguel A. Lanaspa, Richard J. Johnson
Summary: Chronic low-grade inflammation is the root cause of non-communicable diseases, including chronic kidney disease, with fructose and uric acid potentially mediating a metabolic switch towards glycolysis in CKD. SGLT2 inhibitors may slow CKD progression by reducing intrarenal glucose and fructose levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Yi-Seul Kim, Ae-Sin Lee, Haeng-Jeon Hur, Sang-Hee Lee, Hyun-Jin Na, Mi-Jeong Sung
Summary: This study investigated the renoprotective effect of Chrysanthemum coronarium L. extract (CC) on adenine (AD)-induced chronic kidney disease (CKD) in mice. The results showed that CC significantly restored the changes in renal function, histopathology, inflammation, and renal interstitial fibrosis caused by AD diet. CC inhibited the expression of inflammatory and fibrotic markers and attenuated AD-induced renal injury. Therefore, CC has the potential to be used as a renoprotective agent or functional food supplement for CKD management.
Review
Pediatrics
Edwin Patino, Oleh Akchurin
Summary: Chronic kidney disease causes alterations in iron metabolism, leading to anemia and the need for iron supplementation. Therapeutic iron supplementation has pleiotropic effects on various organ systems in CKD patients, beyond traditional hematologic effects. The effects of iron supplementation depend on the administration route and the specific iron preparation used.
PEDIATRIC NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Prabhatchandra Dube, Fatimah K. Khalaf, Armelle DeRiso, Chrysan J. Mohammed, Jacob A. Connolly, Dhanushya Battepati, Apurva Lad, Joshua D. Breidenbach, Andrew L. Kleinhenz, Bella Khatib-Shahidi, Mitra Patel, Iman Tassavvor, Amira F. Gohara, Deepak Malhotra, Eric E. Morgan, Steven T. Haller, David J. Kennedy
Summary: This study suggests that the loss of PON-1 in a salt-sensitive hypertensive model of chronic kidney disease leads to increased cardiac inflammation and fibrosis, as well as a molecular and functional cardiac phenotype consistent with compensated left ventricular hypertrophy.
Article
Pharmacology & Pharmacy
Satoyasu Ito, Eri Manabe, Yi Dai, Masaharu Ishihara, Takeshi Tsujino
Summary: The study suggests that Juzentaihoto (TJ-48) may exert a renal protective effect in mice with adenine-induced chronic kidney disease by suppressing fibrosis and inflammation.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Chelsy L. Cliff, Bethany M. Williams, Christos E. Chadjichristos, Ulrik Mouritzen, Paul E. Squires, Claire E. Hills
Summary: Diabetes is a chronic disease characterized by elevated blood glucose and inflammation, leading to kidney and eye complications. Clinical interventions that can delay and prevent disease progression are in high demand. Connexins, membrane bound proteins that can open under pathological conditions and release danger signals, have shown positive outcomes in models of diabetes complications. Blocking connexin-43 specific hemichannels can improve tissue health and function in diabetic eye and kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sonja Djudjaj, Panagiotis Kavvadas, Niki Prakoura, Roman D. Buelow, Tiffany Migeon, Sandrine Placier, Christos E. Chadjichristos, Peter Boor, Christos Chatziantoniou
Summary: By overexpressing ICN3 in a transgenic mouse model, we found that Notch3 signaling promotes tubular cell proliferation, alignment of cell division, dedifferentiation and hyperplasia, leading to cystic kidney diseases and pre-neoplastic lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Francesca Marta Elli, Deborah Mattinzoli, Camilla Lucca, Matteo Piu, Maria A. Maffini, Jole Costanza, Laura Fontana, Carlo Santaniello, Concetta Forino, Donatella Milani, Maria Teresa Bonati, Andrea Secco, Roberto Gastaldi, Carlo Alfieri, Piergiorgio Messa, Monica Miozzo, Maura Arosio, Giovanna Mantovani
Summary: Skeletal disorders are caused by genetic defects that affect the pathways involved in skeletogenesis and growth-plate development. A study identified novel genetic variants associated with skeletal malformations similar to Albright's hereditary osteodystrophy and confirmed their pathogenic impact. The study highlights the importance of interdisciplinary collaboration in rare patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Anna Regalia, Matteo Benedetti, Silvia Malvica, Carlo Alfieri, Mariarosaria Campise, Donata Cresseri, Maria Teresa Gandolfo, Federica Tripodi, Giuseppe Castellano, Piergiorgio Messa
Summary: In kidney transplanted patients, those with SARS-CoV-2 infection had lower levels of 25(OH)D compared to controls, but there was no significant association between vitamin D status and severity or outcomes of the infection.
Article
Endocrinology & Metabolism
C. Crotti, F. Zucchi, C. Alfieri, R. Caporali, M. Varenna
Summary: This case report describes the long-term efficacy and safety profile of burosumab in a TIO patient who had three unsuccessful surgical attempts in tumor removal. Burosumab showed promising results in improving pain, physical performance, and normalizing serum phosphate levels in TIO patients refractory to surgery or not eligible for surgical treatment.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Virgilia Sahiri, Jonathan Caron, Elena Roger, Christophe Desterke, Khalil Ghachem, Inna Mohamadou, Justine Serre, Niki Prakoura, Soraya Fellahi, Sandrine Placier, Sahil Adriouch, Lu Zhang, Christos E. Chadjichristos, Christos Chatziantoniou, Hans Kristian Lorenzo, Jean-Jacques Boffa
Summary: A study found that the progression of FSGS is correlated with podocyte apoptosis, in which ISM1 plays an important role. Overexpression of ISM1 was observed during FSGS progression and localized in glomeruli, while it partially restored when the disease improved. Further in vitro experiments demonstrated that ISM1 interacts with its receptors GRP78 and integrin alpha v beta 5 on podocytes, inducing apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Barbara Infante, Francesca Conserva, Paola Pontrelli, Serena Leo, Alessandra Stasi, Marco Fiorentino, Dario Troise, Andrea dello Strologo, Carlo Alfieri, Loreto Gesualdo, Giuseppe Castellano, Giovanni Stallone
Summary: Several insults, especially diabetes, can lead to acute kidney injury (AKI) in both native kidney and transplant patients. High glucose levels disrupt signaling pathways within the kidney, causing maladaptive repair and kidney dysfunction. Diabetic kidneys are often vulnerable to hypoxia due to reduced oxygenation, vascular damage, and increased inflammation. Patients with a history of AKI have a worse prognosis, highlighting the importance of monitoring diabetic patients for AKI. This review focuses on the molecular mechanisms underlying increased susceptibility to AKI in diabetes and the potential biomarkers for diagnosis and prognosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Adamasco Cupisti, Domenico Giannese, Claudia D'Alessandro, Alessia Benedetti, Vincenzo Panichi, Carlo Alfieri, Giuseppe Castellano, Piergiorgio Messa
Summary: Complementary and alternative medicine (CAM), including herbal remedies, probiotics, and vitamins, is often used in the treatment of kidney stone patients. However, most dietary supplements claiming to treat or prevent kidney stones lack scientific evidence. Clinicians should inform patients that the effects of these supplements are largely unknown and that absence of evidence does not mean lack of potential harm. Despite the popularity of CAM products among kidney stone patients, the lack of knowledge in this field prevents their recommendation in daily clinical practice, with only a weak suggestion for their use being reasonable.
Review
Nutrition & Dietetics
Jordi Bover, Elisabet Masso, Laia Gifre, Carlo Alfieri, Jordi Soler-Majoral, Maria Fusaro, Jordi Calabia, Rosely Rodriguez-Pena, Nestor Rodriguez-Chitiva, Victor Lopez-Baez, Maya Sanchez-Baya, Iara da Silva, Armando Aguilar, Misael C. Bustos, Natacha Rodrigues, Jonathan S. Chavez-Iniguez, Gregorio Romero-Gonzalez, Jose Manuel Valdivielso, Pablo Molina, Jose L. Gorriz
Summary: Chronic kidney disease (CKD) is a common condition that impairs kidney function and can lead to vitamin D (VD) deficiency. While studies have shown a link between low VD levels and negative outcomes, recent research has lowered expectations for the benefits of VD supplementation. However, guidelines still recommend VD supplementation for CKD patients. It is important to carefully balance the adverse effects of VD derivatives with the prevention of severe secondary hyperparathyroidism.
Review
Urology & Nephrology
Deborah Mattinzoli, Paolo Molinari, Gregorio Romero-Gonzalez, Jordi Bover, Elisa Cicero, Francesco Pesce, Matteo Abinti, Costanza Conti, Giuseppe Castellano, Carlo Alfieri
Summary: Cardio-renal syndrome is a well-defined clinical condition that involves interactions between the heart and kidney. Acute kidney injury can lead to chronic cardiovascular events and the progression of kidney disease. The role of bone in this relationship, as well as the impact on long-term outcomes, is an important topic of research.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Hematology
Rossana Franzin, Alessandra Stasi, Gianvito Caggiano, Elena Squiccimarro, Vincenzo Losappio, Marco Fiorentino, Carlo Alfieri, Giovanni Stallone, Loreto Gesualdo, Giuseppe Castellano
Summary: ESRD is associated with immune dysregulation caused by factors such as uremia and hemodialysis membrane biocompatibility. Understanding the molecules involved in altered immune response is important for therapeutic intervention. PMMA-based membranes have adsorptive properties for uremic toxins and can modulate adaptive immune response.
BLOOD PURIFICATION
(2023)
Review
Genetics & Heredity
Louis Boutin, Elena Roger, Etienne Gayat, Francois Depret, Marcel Blot-Chabaud, Christos E. Chadjichristos
Summary: This review provides an overview of the role of CD146 in renal pathophysiology. Experimental and clinical studies have revealed its significance in various renal diseases, and its expression is regulated during renal injury.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Review
Surgery
Matteo Abinti, Evaldo Favi, Carlo Maria Alfieri, Francesca Zanoni, Silvia Armelloni, Mariano Ferraresso, Vincenzo Cantaluppi, Giuseppe Castellano
Summary: Kidney transplantation is the best treatment for end-stage kidney disease, but early diagnosis of graft injury and improving graft outcomes remain challenging. Extracellular vesicles have shown potential as precise markers of damage and therapeutic targets in the field of kidney transplantation. They can be used to determine organ quality and aging, identify transplant-related pathologies, and are suitable for drug delivery and therapy development.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Alessandra Brescacin, Samuele Iesari, Sonia Guzzo, Carlo Maria Alfieri, Ruggero Darisi, Marta Perego, Carmelo Puliatti, Mariano Ferraresso, Evaldo Favi
Summary: Allograft vesicoureteral reflux (VUR) is a common complication of kidney transplantation, but there is still debate over the risk factors, impact on renal function, and treatment options. Clinical manifestations vary, and treatment should be tailored based on patient characteristics and the severity of VUR. Current evidence supporting surgical referral is weak, and more research is needed to address these issues.
MEDICINA-LITHUANIA
(2022)
Article
Critical Care Medicine
L. Boutin, M. Legrand, M. Sadoune, A. Mebazaa, E. Gayat, C. E. Chadjichristos, F. Depret
Summary: Plasma levels of Gal-3 are strongly associated with renal function, with an increased risk of MAKE and death after ICU admission.