Article
Immunology
Sean E. DeWolf, Sashi G. Kasimsetty, Alana A. Hawkes, Lisa M. Stocks, Sunil M. Kurian, Dianne B. McKay
Summary: This study demonstrates for the first time that endogenous DAMPs released from injured RTECs directly activate PRR signaling in healthy RTECs. These findings provide new insights for the treatment of renal IRI.
Article
Biochemistry & Molecular Biology
Theodoros Eleftheriadis, Georgios Pissas, Spyridon Golfinopoulos, Maria Efthymiadi, Christina Poulianiti, Maria Anna Polyzou Konsta, Vassilios Liakopoulos, Ioannis Stefanidis
Summary: This study evaluated the response of renal proximal tubular epithelial cells (RPTECs) to high albumin concentration, focusing on the unfolded protein response (UPR) and DNA damage response (DDR). The results showed that albumin led to reactive oxygen species (ROS) overproduction and protein modification, which activated both UPR and DDR. This resulted in cellular apoptosis, senescence, and epithelial-to-mesenchymal transition (EMT). While agents against endoplasmic reticulum stress (ERS) only partially alleviated the harmful effects, inhibiting ROS upregulation prevented both UPR and DDR. Therefore, suppressing ROS overproduction may be more effective in mitigating the deleterious effects of albumin overload.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Chao Li, Wei Wang, Shuai-shuai Xie, Wen-xian Ma, Qian-wen Fan, Ying Chen, Yuan He, Jia-nan Wang, Qin Yang, Hai-di Li, Juan Jin, Ming-ming Liu, Xiao-ming Meng, Jia-gen Wen
Summary: Sepsis-induced acute kidney injury (AKI) is a severe complication that involves multiple types of cells such as macrophages, ECs, and TECs, with programmed cell death playing a significant role. Mitochondrial dysfunction and oxidative stress are traditionally considered as the main triggers, while recent research highlights the involvement of autophagy, mitochondria quality control, and epigenetic modification in the process of programmed cell death.
FRONTIERS IN MEDICINE
(2021)
Review
Urology & Nephrology
Sanne van der Rijt, Jaklien C. Leemans, Sandrine Florquin, Riekelt H. Houtkooper, Alessandra Tammaro
Summary: Kidney tubular epithelial cells play a crucial role in the response to kidney injury and repair, and their metabolic abnormalities may contribute to kidney disease. Receptors of the innate immune system regulate the metabolic processes of these cells, and the interplay between immunometabolism and kidney health should be taken into consideration.
NATURE REVIEWS NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuai Wang, Rong Guo, Yongxia Su, Chen Yang, Yazhou Guo, Chengjian Tan, Baoyu Zhao
Summary: Research has shown that Swainsonine induces both autophagy and apoptosis in cells, with autophagy playing a protective role. Modulating autophagy can affect the severity of apoptosis in cell damage caused by Swainsonine's toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Pharmacology & Pharmacy
Mengru Ding, Zhiyan Tang, Wei Liu, Taili Shao, Pingchuan Yuan, Kaoshan Chen, Yuyan Zhou, Jun Han, Jing Zhang, Guodong Wang
Summary: Studies have shown that burdock fructooligosaccharide (BFO) can protect NRK-52E cells against damage induced by high glucose by inhibiting apoptosis and oxidative stress. The anti-oxidative stress effects of BFO are related to the inhibition of reactive oxygen species production, stabilization of mitochondrial membrane potential, and increased antioxidant activities.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Ying-Ying Li, Zeng-Hui Tian, Shan-Shan Su, Jing-Jing Shi, Chao Zhou, Li-Hua Zhang, Fa-Rong Zhang, Yan-Ke Hao
Summary: This study showed that HDHW inhibits apoptosis of RTECs by modulating the PI3K/Akt/mTOR signaling pathway, providing experimental evidence for its anti-fibrotic effect on the kidneys and partially elucidating its pharmacological mechanism of action.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Zejing Wei, Gaohui Nie, Fan Yang, Shaoxing Pi, Chang Wang, Huabin Cao, Xiaoquan Guo, Ping Liu, Guyue Li, Guoliang Hu, Caiying Zhang
Summary: Cadmium exposure induces pyroptosis in duck renal tubular epithelial cells through the ROS/NLRP3/Caspase-1 signaling pathway, while inhibiting Caspase-1 dependent pyroptosis attenuates Cd-induced apoptosis. The combination treatment of Cd and Z-YVAD-FMK significantly improves Cd-induced damage by reducing apoptosis ratio and cell damage.
ENVIRONMENTAL POLLUTION
(2021)
Article
Cell Biology
Alexandra Linke, Hakan Cicek, Anne Mueller, Catherine Meyer-Schwesinger, Simon Melderis, Thorsten Wiech, Claudia Wegscheid, Julius Ridder, Oliver M. Steinmetz, Linda Diehl, Gisa Tiegs, Katrin Neumann
Summary: This study found that proximal tubular epithelial cells (PTECs) have the capacity for antigen cross-presentation, which can modulate the immune response in immune-mediated glomerular diseases, such as lupus nephritis.
Review
Transplantation
Eleni Stamellou, Katja Leuchtle, Marcus J. Moeller
Summary: Acute tubular injury is the most common intrinsic cause of acute kidney injury, and tubular cells can exhibit a rapid capacity for regeneration and repair upon injury. The scattered tubular cell (STC) phenotype represents a uniform reaction triggered by injury, characterized by increased robustness and proliferation during tubular damage.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Theodoros Eleftheriadis, Georgios Pissas, Spyridon Golfinopoulos, Maria Efthymiadi, Vassilios Liakopoulos, Ioannis Stefanidis
Summary: Inhibition of malate dehydrogenase-2 (MDH-2) protects renal cells from death or senescence caused by ischemia-reperfusion injury. MDH-2 inhibition reduces oxidative stress and inflammation, and maintains cell proliferation capacity.
Article
Environmental Sciences
Shaoxing Pi, Gaohui Nie, Zejing Wei, Fan Yang, Chang Wang, Chenghong Xing, Guoliang Hu, Caiying Zhang
Summary: This study found that excess molybdenum can induce pyroptosis in duck renal tubular epithelial cells through the ROS/NLRP3/Caspase-1 pathway, and inhibiting Caspase-1-dependent pyroptosis may weaken molybdenum-induced apoptosis. This provides a theoretical basis for nephrotoxic research on waterfowl exposed to excess molybdenum, and highlights a new mechanism of interaction between pyroptosis and apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Sandra Rayego-Mateos, Jose Luis Morgado-Pascual, Carolina Lavoz, Raul R. Rodrigues-Diez, Laura Marquez-Exposito, Antonio Tejera-Munoz, Lucia Tejedor-Santamaria, Irene Rubio-Soto, Vanessa Marchant, Marta Ruiz-Ortega
Summary: This study aimed to locate the cellular binding sites of CCN2/EGFR in the kidney. The results showed that CCN2 primarily binds to tubular epithelial cells, and the activation of CCN2(IV) can promote the progression of kidney damage.
Article
Cell Biology
Guihu Luo, Yi He, Fangyuan Yang, Zeqing Zhai, Jiaochan Han, Wenchao Xu, Jialin Zhang, Lili Zhuang, Yanan Zhang, Yehao Li, Rui Song, Xiaoqing Luo, Jianheng Liang, Erwei Sun
Summary: GSDME-mediated pyroptosis is associated with SLE pathogenesis, and targeting GSDME may be a potential strategy for treating SLE.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Yadi Cao, Juan Xu, Di Cui, Lei Liu, Shiqi Zhang, Bing Shen, Yonggui Wu, Qiu Zhang
Summary: The study found that carnosine can alleviate oxidative stress in DN by inhibiting apoptosis pathway, showing potential therapeutic effects.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Urology & Nephrology
Miriam Anfaiha-Sanchez, Emilio Rodrigo Calabia, Alberto Ortiz, Marta Martin-Lorenzo, Gloria Alvarez-Llamas
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure, but ensuring the long-term performance of the transplanted kidney remains challenging. Current research focuses on the risk of primary non-function and delayed graft function as well as recipient survival, making it increasingly difficult to predict if the grafts will provide sufficient kidney function.
CLINICAL KIDNEY JOURNAL
(2023)
Editorial Material
Urology & Nephrology
Alberto Ortiz, Christoph Wanner, Ron Gansevoort, Era Council
Summary: The European Society of Cardiology's 2021 guideline on cardiovascular disease prevention has important implications for CV risk screening and kidney health. It emphasizes the need for categorizing individuals based on established conditions such as atherosclerotic CVD, diabetes, hypercholesterolemia, or chronic kidney disease. The inclusion of albuminuria as a step in CVD risk assessment should change clinical practice. Further research is needed to determine the optimal method for assessing CV risk in the general population, including the role of systematic screening for CKD.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Mehmet Kanbay, Sidar Copur, Dimitrie Siriopol, Abdullah Burak Yildiz, Metehan Berkkan, Raluca Popa, Nuri Baris Hasbal, Alberto Ortiz, Mark A. Perazella
Summary: The development of acute kidney injury (AKI) in cancer patients receiving immune checkpoint inhibitors is associated with an increased risk of mortality.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Gregorio Romero-Gonzalez, Joaquin Manrique, Maria F. Slon-Roblero, Faeq Husain-Syed, Rafael De la Espriella, Fiorenza Ferrari, Jordi Bover, Alberto Ortiz, Claudio Ronco
Summary: Point-of-Care Ultrasonography (PoCUS) is a method that adds sonographic imaging to the classical physical examination to help clinicians answer specific questions at the bedside. In recent years, PoCUS has become a valuable tool in clinical practice, improving the accuracy of diagnosis and assessment of renal diseases.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Luis M. Ruilope, Alberto Ortiz, Alejandro Lucia, Blanca Miranda, Gloria Alvarez-Llamas, Maria G. Barderas, Massimo Volpe, Gema Ruiz-Hurtado, Bertram Pitt
Summary: Chronic kidney disease (CKD) is a leading cause of death that requires early detection for effective management. The current diagnostic criteria for CKD only identify advanced stages, leaving a 'blind spot' in detection where kidney injury is present but undetectable. Elevated urinary albumin-excretion rate can predict future cardiovascular events. Implementing opportunistic or systematic albuminuria screening and therapy has the potential to improve cardiorenal outcomes and mitigate the projected burden of CKD and cardiovascular diseases in the future.
EUROPEAN HEART JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Nerea Mendez-Barbero, Jorge Oller, Ana B. Sanz, Adrian M. Ramos, Alberto Ortiz, Marta Ruiz-Ortega, Sandra Rayego-Mateos
Summary: Cardiovascular disease (CVD) often accompanies chronic kidney disease (CKD), and patients with both conditions have an increased risk of all-cause mortality ranging from 20% to 500%. Maintaining mitochondrial homeostasis appears to be a promising therapeutic strategy for the cardio-renal syndrome (CRS). This review explores the role of mitochondrial dysfunction in cardiovascular and renal diseases and how it may guide the development of novel therapeutic strategies for CRS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Transplantation
Beatriz Martin-Carro, Juan F. Navarro-Gonzalez, Alberto Ortiz, Carmine Zoccali, Jurgen Floege, Manuel A. Ferreira, Jose L. Gorriz-Teruel, Natalia Carrillo-Lopez, Sara Panizo, Francesco Locatelli, Markus Ketteler, Gerard M. London, Manuel Naves-Diaz, Cristina Alonso-Montes, Jorge B. Cannata-Andia, Jose L. Fernandez-Martin
Summary: This study found that diabetic patients on haemodialysis have a higher risk of mortality, and high serum parathyroid hormone (PTH) levels are particularly associated with increased mortality risk in diabetic patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Maria D. Sanchez-Nino, Maria I. Ceballos, Sol Carriazo, Aranzazu Pintor-Chocano, Ana B. Sanz, Moin A. Saleem, Alberto Ortiz
Summary: The interaction between diabetes and Fabry disease may increase the severity of kidney damage by modulating the Gb3 synthesis pathway and downregulating kidney protective genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jonay Poveda, Laura Gonzalez-Lafuente, Sara Vazquez-Sanchez, Elisa Mercado-Garcia, Elena Rodriguez-Sanchez, Ines Garcia-Consuegra, Ana Belen Sanz, Julian Segura, Maria Fernandez-Velasco, Fernando Liano, Luis M. Ruilope, Gema Ruiz-Hurtado
Summary: This study establishes the relevance of the TWEAK-Fn14 pathway in cardiac dysfunction linked to CRS3, both as a predictor of mortality in patients with AKI and as a Ca2+ mishandling inducer in cardiomyocytes, and highlights the cardioprotective benefits of TWEAK targeting in CRS3.
JOURNAL OF PATHOLOGY
(2023)
Article
Transplantation
Pedro Barrera-Baena, Minerva Rodriguez-Garcia, Enrique Rodriguez-Rubio, Lucia Gonzalez-Llorente, Alberto Ortiz, Carmine Zoccali, Francesco Locatelli, Juergen Floege, Martine Cohen-Solal, Manuel Anibal Ferreira, Markus Ketteler, Gerard Michel London, Jose Luis Gorriz-Teruel, Emilio Sanchez-Alvarez, Miguel Angel Hevia-Suarez, Jesus Maria Fernandez-Gomez, Beatriz Martin-Carro, Carlos Gomez-Alonso, Cristina Alonso-Montes, Jorge Benito Cannata-Andia, Jose Luis Fernandez-Martin
Summary: This study analyzed the association between biochemical parameters of CKD-MBD and bone fragility fractures in hemodialysis patients, and found that hyperphosphatemia is independently and consistently associated with an increased risk of bone fractures.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Jorge E. Rojas-Rivera, Sevcan A. Bakkaloglu, Davide Bolignano, Ionut Nistor, Pantelis A. Sarafidis, Sokratis Stoumpos, Mario Gennaro Cozzolino, Alberto Ortiz, ERA ERBP
Summary: Chronic kidney disease (CKD) is diagnosed based on glomerular filtration rate (GFR) and urinary albumin:creatinine ratio (UACR). High cardiovascular risk is associated with moderate or severe CKD. The management recommendations for lupus nephritis (LN) and cardiovascular risk in rheumatic and musculoskeletal diseases do not consider albuminuria or CKD. The authors propose a change in the conceptual framework to treat LN as a cause of CKD and apply evidence from large CKD trials.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Sandra Rayego-Mateos, Laura Marquez-Exposito, Pamela Basantes, Lucia Tejedor-Santamaria, Ana B. Sanz, Tri Q. Nguyen, Roel Goldschmeding, Alberto Ortiz, Marta Ruiz-Ortega
Summary: Inflammation is a key characteristic of kidney diseases, and the NLRP3/Inflammasome, RIPK3, and NRF2/oxidative pathways are involved in kidney inflammation regulation. CCN2 is a fibrotic biomarker and mediator of kidney damage, and its role in the NLRP3/RIPK3/NRF2 pathways has not been evaluated.
Article
Urology & Nephrology
Sol Carriazo, Marta Ribagorda, Aranzazu Pintor-Chocano, Maria Vanessa Perez-Gomez, Alberto Ortiz, Maria Dolores Sanchez-Nino
Summary: Chronic kidney disease, especially diabetic kidney disease, is associated with altered expression of SCARF genes in target organs of COVID-19, potentially increasing susceptibility to SARS-CoV-2 infection.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Pantelis Sarafidis, Fotini Iatridi, Charles Ferro, Maria-Eleni Alexandrou, Beatriz Fernandez-Fernandez, Mehmet Kanbay, Francesca Mallamaci, Ionut Nistor, Patrick Rossignol, Christoph Wanner, Mario Cozzolino, Alberto Ortiz, ERBP Board
Summary: Chronic kidney disease (CKD) in individuals with type 2 diabetes is a major public health issue. Renin-angiotensin system (RAS) blockers have been the standard treatment, but their effectiveness in reducing cardiovascular events and mortality is limited. Non-steroidal mineralocorticoid receptor antagonists (MRAs) have gained interest due to their better pharmacologic profile. Finerenone, the first compound of this class, has shown promise in reducing kidney disease progression and cardiovascular outcomes in patients with type 2 diabetes.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Alberto Ortiz
Summary: Diabetes is the leading cause of chronic kidney disease (CKD) and more research is needed to understand its distinct phenotypes in patients with CKD. Routine kidney biopsy may be overused in CKD patients with diabetes, and expanding the biopsy criteria may result in more complications. Limited resources should be allocated optimally for early diagnosis and preventive treatment.
CLINICAL KIDNEY JOURNAL
(2023)
