Article
Multidisciplinary Sciences
Elias Crum, Zubia Merchant, Adriana Ene, Taylor Miller-Ensminger, Genevieve Johnson, Alan J. Wolfe, Catherine Putonti
Summary: Due to its association with UTIs, Escherichia coli is the best characterized constituent of the urobiome. The urobiome also contains a diverse population of bacteriophages, including prophages integrated into bacterial genomes. This study identified and examined the diversity of urinary coliphages, finding that they can infect and lyse urinary E. coli strains, suggesting a role in modulating the E. coli strain diversity of the urobiome.
Letter
Immunology
Mohamed Lamine Keita, Madjid Morsli, Marc Levy, Gregoire Basse, Cecile Verrier, Michel Drancourt
Summary: We characterized an aquatic zoonotic opportunistic pathogen, Mycobacterium angelicum, which belongs to the M. szulgai complex, using a polyphasic approach that included whole-genome sequencing. The pathogen's sequence was obtained from a urine specimen collected from a patient with a urinary tract infection on the island of Tahiti, French Polynesia.
EMERGING INFECTIOUS DISEASES
(2023)
Review
Immunology
Sofia Sanchez, Nicolas Navarro, Johanna Catalan-Figueroa, Javier O. Morales
Summary: Urinary tract infection is a common reason for antibiotic treatment, but uropathogens are increasingly becoming resistant to current therapies. Nanotechnology presents an innovative and promising approach for UTI treatment, with various nanoparticles showing potential impact against uropathogens both in vivo and in vitro.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Nadia Kadry, Mukil Natarajan, Edward Bein, Peter Kim, John Farley
Summary: In clinical trials for complicated urinary tract infection, some participants show clinical success but still have microbiological persistence in the urine, which increases the risk of future clinical failure. Current guidelines recommend assessing both clinical and microbiological responses after therapy, but discordant outcomes raise questions about the utility of the microbiological endpoint. Analysis of participant data from 13 clinical trials shows that discordant outcomes at the test of cure visit are associated with an increased risk of late clinical failure, suggesting the importance of microbiological outcomes in the endpoint.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Immunology
Virginia Perez-Carrasco, Ana Soriano-Lerma, Miguel Soriano, Jose Gutierrez-Fernandez, Jose A. Garcia-Salcedo
Summary: The application of next generation sequencing techniques has revealed that the urinary tract is not sterile, contrary to previous beliefs. Microbial communities in the urinary tract play a crucial role in maintaining health and are associated with various urinary pathologies. Understanding the urinary microbiome in health and disease could lead to the development of new therapeutic strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Chemistry, Physical
Deepak Patil, Sivanandam Aravindan, Arijit Pal, Wajihul H. Khan, Pragya Pragya, Swati Pundir, Immaculata Xess, Sarita Mohapatra, Vivekanandan Perumal, P. Venkateswara Rao
Summary: This study developed a simple method for making superhydrophobic micro-structured antibacterial polymer surfaces for coating-free catheters. The results showed that the pillar-structured surface exhibited higher water repellency and more efficiently reduced bacterial attachment compared to a plain surface.
SURFACES AND INTERFACES
(2023)
Article
Microbiology
Silvia Colussi, Paolo Pastorino, Marino Prearo, Simona Sciuto, Fabio Bondavalli, Pier Luigi Acutis, Elena Bozzetta, Francesco Amisano, Angelo Salerno
Summary: This paper reports the first human urinary tract infection caused by Lactococcus petauri, highlighting the expected increase in human L. petauri infections and calling for further investigations to understand their role as pathogens and zoonotic agents.
Article
Oncology
Jan T. Klein, Axel John, Lars Bohnert, Markus D. Enderle, Walter Linzenbold, Christian Bolenz
Summary: This study compared the feasibility and quality of biopsy specimens obtained by cryobiopsy and standard biopsy techniques in an ex vivo human model. Cryobiopsy provided larger and higher quality specimens with fewer artifacts compared to standard instrumentation. Further development is needed to apply the promising cryobiopsy technique in a clinical setting.
FRONTIERS IN ONCOLOGY
(2022)
Article
Infectious Diseases
Jemal Ahmed, Ahmedmenewer Abdu, Habtamu Mitiku, Zerihun Ataro
Summary: This study evaluated the in-vitro antibacterial activity of Punica granatum fruit peels, Nigella sativa seeds, and Echinops kebericho roots against uropathogenic bacteria. The results showed that the crude extract of Punica granatum fruit peels had the highest inhibition zones, followed by Nigella sativa seeds, while Echinops kebericho roots had the smallest efficacy. These findings suggest that Punica granatum fruit peels, Nigella sativa seeds, and Echinops kebericho roots have promising antibacterial activity against uropathogenic bacteria.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Microbiology
Nicole E. Scangarella-Oman, Mohammad Hossain, Jennifer L. Hoover, Caroline R. Perry, Courtney Tiffany, Aline Barth, Etienne F. Dumont
Summary: This article reviews data for Gepotidacin from nonclinical studies, including in vitro activity, in vivo animal efficacy, and pharmacokinetic/pharmacodynamic models. The selected dose for phase III clinical evaluation of Gepotidacin in the treatment of uUTIs is a 1,500-mg oral dose twice daily for 5 days.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Buddhika Gayani, Ayomi Dilhari, Nilwala Kottegoda, Dilru R. Ratnaweera, Manjula Manoji Weerasekera
Summary: TFP-PDMS, an antibiofilm forming surface without any antibacterial agent, displayed reduced bacterial attachment compared to silver-coated latex and silicone catheter surfaces. The enhanced antibiofilm forming ability of TFP-PDMS was attributed to the self-cleaning activity of the surface, as determined by elemental analysis. This modified surface is believed to significantly reduce biofilm formation in indwelling urinary catheters and warrant future clinical studies.
Article
Urology & Nephrology
Monique H. Vaughan, Jialiang Mao, Lisa A. Karstens, Li Ma, Cindy L. Amundsen, Kenneth E. Schmader, Nazema Y. Siddiqui
Summary: The study found associations between anaerobic bacteria in the urinary microbiome and postmenopausal recurrent UTI, suggesting a need for further investigation.
JOURNAL OF UROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nela Kelam, Anita Racetin, Mirjana Polovic, Benjamin Benzon, Marin Ogorevc, Katarina Vukojevic, Merica Glavina Durdov, Ana Dunatov Huljev, Ivana Kuzmic Prusac, Davor Caric, Fila Raguz, Sandra Kostic
Summary: This study investigates the expression patterns of candidate genes for kidney and urinary tract congenital anomalies in human fetal kidney development. The results reveal significant variations in the expression patterns of these genes, suggesting their involvement in CAKUT pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Noemie Luyts, Jan Daniluk, Ana Cristina Nogueira Freitas, Bahar Bazeli, Annelies Janssens, Marie Mulier, Wouter Everaerts, Thomas Voets
Summary: In this study, the effect of Phenazopyridine (PAP) on pain-related Transient Receptor Potential (TRP) channels was investigated. The results showed that PAP can rapidly and reversibly inhibit the cold and menthol sensitivity of TRPM8 channels. This suggests that the inhibition of TRPM8 may be the mechanism underlying the analgesic activity of PAP.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Khaireddine Bouassida, Manel Marzouk, Sahar Nouir, Rim Ghammem, Wissal Sahtout, Meriam Ghardallou, Neila Fathallah, Jalel Boukadida, Mehdi Jaidane, Raoudha Slim, Amira Zairi
Summary: This study aimed to evaluate the spectrum of bacterial pathogens in ureteral double-J stents and their susceptibility to natural compounds. The results showed that extracts from Globularia alypum L. exhibited antibacterial and antibiofilm activity, especially against Acinetobacter baumanii.
