Article
Biochemistry & Molecular Biology
Raphaelle Corremans, Patrick C. D'Haese, Benjamin A. Vervaet, Anja Verhulst
Summary: The study successfully developed a rat model of DKD by combining STZ/NAD and oral L-NAME, inducing diabetes, hypertension, and characteristic features of DKD, providing a new animal model for DKD research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Chin-Chou Huang, Chia-Min Chung, Chih-Yu Yang, Hsin-Bang Leu, Po-Hsun Huang, Liang-Yu Lin, Tao-Cheng Wu, Shing-Jong Lin, Wen-Harn Pan, Jaw-Wen Chen
Summary: This study found an association between SLC12A3 gene polymorphisms and renal function in patients with hypertension.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Jun-Li Tsai, Cheng-Hsu Chen, Ming-Ju Wu, Shang-Feng Tsai
Summary: Diabetic nephropathy is the leading cause of end-stage kidney disease and has the worst prognosis compared to other causes. There is still a need for improvement in the renal outcomes of diabetes mellitus. However, there is solid clinical evidence for treating diabetic nephropathy. Recent breakthroughs have identified key mechanisms and treatments for diabetic nephropathy.
Article
Oncology
Burcu Isik, Metin Suleymanzade, Mahir Cengiz, Serap Yavuzer, Mehmet Sami Islamoglu, Betul Borku Uysal, N. Ozlem Harmankaya, Mehmet Giray Ersoz
Summary: Choroidal thickness is decreased in patients with type 2 diabetes and glomerular hyperfiltration, but there is no significant difference in choroidal vascularity index compared to patients without diabetic nephropathy.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Sport Sciences
Conghui Liu, Brooklyn J. Fraser, Ye He, Matthew D. Jose, Costan G. Magnussen, Jing Tian, Terence Dwyer, Alison J. Venn
Summary: This study investigated the relationship between childhood cardiorespiratory fitness and early markers of chronic kidney disease in midlife. It found that females with lower childhood cardiorespiratory fitness had a higher risk of glomerular hyperfiltration in midlife.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2022)
Article
Urology & Nephrology
Vidar T. N. Stefansson, Viji Nair, Toralf Melsom, Helen C. Looker, Laura H. Mariani, Damian Fermin, Felix Eichinger, Rajasree Menon, Lalita Subramanian, Patricia Ladd, Roger Harned, Jennifer L. Harder, Jeffrey B. Hodgin, Petter Bjornstad, Peter J. Nelson, Bjorn O. Eriksen, Robert G. Nelson, Matthias Kretzler
Summary: Hyperfiltration is a characteristic of early diabetic kidney disease that damages glomeruli and increases glomerular load. Our study reveals the molecular pathomechanisms associated with hyperfiltration, involving cellular crosstalk between endothelial and mesangial cells.
KIDNEY INTERNATIONAL
(2022)
Review
Urology & Nephrology
Pooja Amarapurkar, Levard Roberts, Jose Navarrete, Fuad El Rassi
Summary: Sickle cell disease can cause various kidney manifestations, such as impaired urine concentration, potassium and hydrogen ion handling, albuminuria, acute kidney injury, and chronic kidney disease. The mechanisms of kidney damage include glomerular hyperfiltration, tubular hyperfunctioning, endothelial damage from repeated sickling and vaso-occlusive episodes, and iron-induced proinflammatory changes. Albuminuria is a common clinical feature of kidney disease in sickle cell patients and tends to worsen with age.
ADVANCES IN CHRONIC KIDNEY DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Luna Jimenez-Castilla, Gema Marin-Royo, Macarena Orejudo, Lucas Opazo-Rios, Teresa Caro-Ordieres, Ines Artaiz, Tatiana Suarez-Cortes, Arturo Zazpe, Gonzalo Hernandez, Carmen Gomez-Guerrero, Jesus Egido
Summary: The synthetic flavonoid hidrosmin has shown protective effects against diabetic nephropathy by reducing inflammation, oxidative stress, and senescence pathways. It may have potential as an adjuvant therapy for chronic complications of diabetes mellitus. Additionally, hidrosmin demonstrated no cytotoxicity at effective concentrations, making it a promising treatment option.
Article
Urology & Nephrology
Seunghyeok Choi, Seon Pyo Hong, Jung Hyun Bae, Sang Heon Suh, Hosung Bae, Kyung Pyo Kang, Hyuek Jong Lee, Gou Young Koh
Summary: This study reveals that high blood glucose in diabetes mellitus activates YAP/TAZ through the canonical Hippo pathway, leading to excessive proliferation of MCs, extracellular matrix deposition, endothelial cell impairment, glomerular sclerosis, albuminuria, and reduced glomerular filtration rate, which are the hallmarks of DN. Mechanistically, YAP/TAZ bind and stabilize N-Myc protein, enhancing its transcriptional activity and eventually causing MC impairments and DN pathogenesis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Endocrinology & Metabolism
Yang Yang, Gaosi Xu
Summary: This paper summarizes the mechanisms of hyperfiltration in early diabetic kidney disease (DKD), including the effect of glucose reabsorption, renal growth, nitric oxide, adenosine, atrial natriuretic peptide, cyclooxygenase, renin-angiotensin-aldosterone system, and endothelin. Potential treatments targeting these mechanisms may provide new therapeutic opportunities for reducing renal burden in DKD patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Samuel N. Heyman, Itamar Raz, Jamie P. Dwyer, Roni Weinberg Sibony, Julia B. Lewis, Zaid Abassi
Summary: Albuminuria is a hallmark of diabetic nephropathy and its development is influenced by various factors. Controlling glomerular albumin leak is crucial for preventing progression of the disease. Early interventions and treatments should be initiated before the onset of microalbuminuria, and the inhibition of the renin-angiotensin axis or sodium-glucose co-transport can be beneficial.
Article
Biochemistry & Molecular Biology
Shokichi Naito, Kenichi Nakayama, Nagako Kawashima
Summary: We found that albuminuria levels in patients with MCD and FSGS are negatively correlated with GM3 expression in glomerular podocytes. Activating GM3 synthesis through VPA administration suppresses albuminuria and podocyte injury. In diabetic nephropathy, enhanced GM3 expression via VPA decreases albuminuria, glomerular lesions, loss of podocytes, and expansion in the mesangial area. The therapeutic effect of maintaining GM3 expression may extend to late-stage diabetic nephropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Transplantation
Hans-Joachim Anders, Anna Julie Peired, Paola Romagnani
Summary: The DAPA-CKD trial demonstrated that the SGLT2 inhibitor, dapagliflozin, attenuates the progression of chronic kidney disease (CKD) with proteinuria in patients with or without diabetes. This has significant implications for the understanding and treatment of CKD, suggesting that SGLT2 inhibition should be a central component in CKD management regardless of diabetes status. It may also impact the treatment approaches for IgA nephropathy and focal segmental glomerulosclerosis.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Biology
Maria Chiara Pelle, Michele Provenzano, Marco Busutti, Clara Valentina Porcu, Isabella Zaffina, Lucia Stanga, Franco Arturi
Summary: Diabetes is a leading cause of kidney disease, specifically diabetic kidney disease (DKD) which is associated with increased cardiovascular risk. Chronic hyperglycemia and high blood pressure are risk factors for DKD, but blockade of the renin-angiotensin-aldosterone system can improve glomerular function and cardiovascular risk. New antidiabetic drugs have shown promise in delaying kidney disease progression and improving cardiovascular outcomes.
Article
Urology & Nephrology
Takaya Sasaki, Kaneyasu Nakagawa, Jun Hata, Yoichiro Hirakawa, Mao Shibata, Toshiaki Nakano, Nobuo Tsuboi, Yoshinao Oda, Takanari Kitazono, Takashi Yokoo, Toshiharu Ninomiya
Summary: The study revealed a positive association between urinary albumin-creatinine ratio levels and the presence of class IIa or higher glomerular diabetic nephropathy (DN) lesions, even in individuals with normoalbuminuria. This suggests that DN lesions can exist in diabetic patients with normal albuminuria levels.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Gastroenterology & Hepatology
Chikatoshi Katada, Saeko Fukazawa, Mitsuhiro Sugawara, Yasutoshi Sakamoto, Kaoru Takahashi, Akiko Takahashi, Akinori Watanabe, Takuya Wada, Kenji Ishido, Yasuaki Furue, Hiroki Harada, Kei Hosoda, Keishi Yamashita, Naoki Hiki, Teruko Sato, Takafumi Ichikawa, Masayoshi Shichiri, Satoshi Tanabe, Wasaburo Koizumi
Summary: Nutritional support provided by an amino acid-rich elemental diet was ineffective for reducing the incidence of adverse events caused by DCF chemotherapy in patients with esophageal cancer, but tended to maintain certain indicators after chemotherapy.
Article
Hematology
Masao Toyoda, Takashi Murata, Nobumichi Saito, Moritsugu Kimura, Hiroo Takahashi, Naoto Ishida, Makoto Kitamura, Miho Hida, Akinori Hayashi, Ibuki Moriguchi, Naoyuki Kobayashi, Daisuke Tsuriya, Yukitoshi Sakao, Takaya Matsushita, Yukie Ito, Shota Suzuki, Shu Kasama, Masato Kasahara, Tadashi Yamakawa, Katsuhito Mori, Akio Kuroda, Junnosuke Miura, Yushi Hirota, Masanori Abe, Masafumi Fukagawa, Naoki Sakane, Kiminori Hosoda
Summary: Research shows that the accuracy of FreeStyle Libre in patients undergoing hemodialysis is lower than expected, and deteriorates with days of usage, necessitating adjunctive use with self-monitoring of blood glucose.
THERAPEUTIC APHERESIS AND DIALYSIS
(2021)
Article
Multidisciplinary Sciences
Tomomi Taguchi, Yoshio Kodera, Kazuhito Oba, Tatsuya Saito, Yuzuru Nakagawa, Yusuke Kawashima, Masayoshi Shichiri
Summary: The study successfully identified three novel bioactive polypeptides derived from suprabasin in plasma using a novel strategy, demonstrating a new approach for discovering unknown bioactive peptides.
SCIENTIFIC REPORTS
(2021)
Article
Peripheral Vascular Disease
Kazumi Fujimoto, Sayuki Kawamura, Satoru Bando, Yuji Kamata, Yoshio Kodera, Masayoshi Shichiri
Summary: The study looked at the molecular forms of human plasma prorenin and developed an enzyme-linked immunosorbent assay to directly measure its concentration. It found that plasma prorenin concentrations are far higher than previously thought, with three major distinct components identified. Additionally, plasma prorenin concentrations were not affected by postural changes, indicating potential posttranslational modifications or albumin binding.
HYPERTENSION RESEARCH
(2021)
Article
Endocrinology & Metabolism
Akinori Hayashi, Naoya Shimizu, Agena Suzuki, Kenta Matoba, Akari Momozono, Tsuguto Masaki, Akifumi Ogawa, Ibuki Moriguchi, Koji Takano, Naoyuki Kobayashi, Masayoshi Shichiri
Summary: Despite the use of dialysate containing 100-150 mg/dL glucose, patients with diabetes undergoing HD experienced HD-related hypoglycemia frequently. SGL showed a sustained decrease during HD, reaching a nadir lower than the dialysate glucose concentration, regardless of the dialysate glucose concentration.
Article
Endocrinology & Metabolism
Hiroaki Iwasaki, Masayoshi Shichiri
Summary: In Japanese patients with type 2 diabetes, the rs3745468 variant in the PRMT1 gene was associated with an increased incidence of proliferative diabetic retinopathy (PDR) and may be involved in the HIF-1-dependent hypoxic pathway through altered PRMT1 levels.
ACTA DIABETOLOGICA
(2022)
Article
Endocrinology & Metabolism
Naoya Shimizu, Akifumi Ogawa, Akinori Hayashi, Masayoshi Shichiri
Summary: This study shows that changes in HbA1c levels may not accurately reflect the glycemic improvements in patients treated with SGLT2 inhibitors. The study suggests that GA may be a more reliable biomarker for evaluating the glucose-lowering effect and glycemic fluctuations induced by SGLT2 inhibitors.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2022)
Article
Peripheral Vascular Disease
Sayuki Kawamura, Kazumi Fujimoto, Akinori Hayashi, Yuji Kamata, Ibuki Moriguchi, Naoyuki Kobayashi, Masayoshi Shichiri
Summary: Although the measurement of plasma prorenin levels is still unavailable in clinical practice, this study found that utilizing a sandwich enzyme-linked immunosorbent assay that captures posttranslationally modified prorenins with their prosegment antibodies, plasma and serum prorenin concentrations can be measured in patients with diabetes mellitus, hypertension and/or renal disease. The results showed no significant difference compared to healthy controls, but were significantly higher than previously reported levels using conventional assay kits. Furthermore, the study found that plasma prorenin levels were negatively correlated with body weight, serum albumin levels, and serum creatinine levels, while the use of loop diuretics was associated with elevated plasma prorenin levels.
HYPERTENSION RESEARCH
(2022)
Article
Urology & Nephrology
Akinori Hayashi, Kenta Matoba, Yasuhiro Ohata, Naoya Shimizu, Agena Suzuki, Satoe Fujii, Marie Sato, Koji Takano, Masayoshi Shichiri
Summary: Through a detailed investigation of blood glucose and hormone levels in patients with type 2 diabetic hemodialysis, it was found that C-peptide and glucagon play an important role in hemodialysis-related glycemic variabilities.
RENAL REPLACEMENT THERAPY
(2022)
Article
Endocrinology & Metabolism
Sayaka Sasaki, Kazuhito Oba, Yoshio Kodera, Makoto Itakura, Masayoshi Shichiri
Summary: The discovery of bioactive peptides is important for understanding human diseases and drug discovery. In this study, a anorexigenic peptide ANGT_HUMAN[448-462] was identified and found to bind to the beta-subunit of ATP synthase. It was shown to suppress eating behavior in mice.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
Article
Endocrinology & Metabolism
Naoya Shimizu, Akinori Hayashi, Shiori Ito, Agena Suzuki, Rei Fujishima, Kenta Matoba, Tatsuhiko Wada, Koji Takano, Masato Katagiri, Masayoshi Shichiri
Summary: This study investigated the accuracy of isCGM in COVID-19 patients during dexamethasone therapy. The results showed that isCGM correlated well with point-of-care measurements and had good reliability in COVID-19 patients with and without diabetes.
Article
Endocrinology & Metabolism
Naoya Shimizu, Akinori Hayashi, Shiori Ito, Agena Suzuki, Rei Fujishima, Kenta Matoba, Tatsuhiko Wada, Koji Takano, Masato Katagiri, Masayoshi Shichiri
Summary: The clinical utility of intermittently scanned continuous glucose monitoring (isCGM) in patients with coronavirus disease 2019 (COVID-19) during dexamethasone therapy was investigated. The accuracy of isCGM compared to point-of-care (POC) fingerstick glucose monitoring was evaluated in 16 patients with COVID-19, showing good correlation and reliability, especially for COVID-19 patients with and without diabetes. While isCGM may not be as accurate as traditional blood glucose monitoring, it demonstrated good reliability in this specific patient population.
Article
Endocrinology & Metabolism
Agena Suzuki, Yuji Kamata, Tomomi Taguchi, Koji Takano, Yuto Yamazaki, Hironobu Sasano, Masayoshi Shichiri
Summary: Advances in imaging technology have led to an increase in the number of identified patients with bilateral adrenal incidentalomas, but there is no consensus on the optimal management of these lesions. This study reports a clinically interesting case of a 59-year-old female with adrenocortical adenoma harboring a venous thrombus that mimicked adrenal malignancy, highlighting the difficulty in preoperatively diagnosing and differentiating between benign and malignant adrenal lesions.
Article
Endocrinology & Metabolism
Akari Momozono, Akinori Hayashi, Koji Takano, Masayoshi Shichiri
Summary: The study demonstrates that growth hormone replacement therapy significantly improves resting energy expenditure and body composition in patients with adult growth hormone deficiency. This therapy leads to an increase in lean body mass, improved lipid metabolism, and no change in body weight over the course of 12 months.
