Journal
KIDNEY INTERNATIONAL
Volume 80, Issue 1, Pages 8-10Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ki.2011.83
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- National Institute for Health Research [ACF-2009-11-004] Funding Source: researchfish
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New data from Kiryluk et al. show the importance of genetic factors in determining the profile of serum IgA1 O-glycoforms in IgA nephropathy and Henoch-Schonlein purpura nephritis. Elevated serum levels of poorly galactosylated IgA1 O-glycoforms do not, however, appear sufficient in themselves to cause nephritis in these two diseases, and a 'second hit' is necessary before changes in IgA1 glycosylation translate into clinical disease. The challenge now is to determine what these genetic factors are.
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