Article
Biotechnology & Applied Microbiology
Liuyang Ren, Ying Lou, Mingyu Sun
Summary: Evodiamine (EVO) is a novel anti-tumor drug that inhibits cell proliferation and invasion in oral squamous cell carcinoma (OSCC). EVO targets the downstream signaling pathways of AGE/RAGE by affecting RAGE, leading to inhibition of proliferation, invasion, and angiogenesis in OSCC cells.
Review
Biochemistry & Molecular Biology
Qing Yue, Yu Song, Zi Liu, Lin Zhang, Ling Yang, Jinlong Li
Summary: RAGE, as a critical molecule in inflammatory response, binds to various ligands and initiates intracellular signal cascade. It plays a vital role in the occurrence and development of immune-related diseases and has crucial functions in different aspects of life activities. Therefore, targeted intervention in the RAGE signaling pathway may have significant therapeutic potential.
Article
Food Science & Technology
Hee-Weon Lee, Min Ji Gu, Jee-Young Lee, Seungju Lee, Yoonsook Kim, Sang Keun Ha
Summary: The study found that MOLD significantly increases RAGE expression in mouse mesangial cells, leading to ROS production and mitochondrial dysfunction. MOLD activates PI3KB and NF-kappa B signaling pathways, triggering inflammatory responses.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hee-Weon Lee, Min Ji Gu, Yoonsook Kim, Jee-Young Lee, Seungju Lee, In-Wook Choi, Sang Keun Ha
Summary: This study evaluated the impact of glyoxal-lysine dimer (GOLD) on oxidative damage and inflammatory response in SV40 MES 13 mesangial cells. GOLD increased RAGE expression, reactive oxygen species production, and regulated NRF2 and GLO1 expression. Additionally, GOLD induced mitochondrial deterioration and inflammation through oxidative stress, and regulated MAPK and proinflammatory cytokines release. Inhibition of RAGE using RAGE siRNA suppressed the oxidative stress and inflammatory responses triggered by GOLD, highlighting the importance of the interaction between GOLD and RAGE in mesangial cell function.
Review
Pharmacology & Pharmacy
Kensei Taguchi, Kei Fukami
Summary: Diabetes, a leading cause of death worldwide, is expected to affect 642 million people by 2040. The concept of diabetic kidney disease (DKD) is widely accepted due to the increasing number of diabetes patients with multiple underlying diseases. Receptor for advanced glycation endproducts (RAGE), a multiligand receptor, is upregulated in patients with diabetes, hypertension, obesity, and chronic inflammation, and can be a therapeutic target for inhibiting the progression of DKD and its complications.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Chemistry, Medicinal
Amna Parveen, Razia Sultana, Seung Min Lee, Tae Hun Kim, Sun Yeou Kim
Summary: Research shows that advanced glycation end products play a crucial role in diabetes and its related complications, while natural products rich in bioactive constituents can control and prevent these diseases through various signaling cascades.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Xue-Meng Zhang, Yuan Gao, Meng-Xue Yang, Xiao-Di Zheng, Rui Zhang, Yue-Yue Wu, Miao Zeng, Qian Yang, Zhi-Yan Yu, Jun Liu, Bing-Bing Zha, Bo Yang
Summary: Diabetic kidney disease (DKD) is a complication of diabetes, and early detection is crucial. This study found that the noninvasive lens AGEs fluorescence detection method can be used to predict the occurrence of DKD, providing clinical value in diagnosing DKD in patients with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kirti Parwani, Farhin Patel, Pranav Bhagwat, Haritha Dilip, Dhara Patel, Vijay Thiruvenkatam, Palash Mandal
Summary: The study investigated the potential of Swertiamarin (SM) in preventing diabetic nephropathy (DN) induced by advanced glycation end products (AGEs) in high fat diet-streptozotocin-induced diabetic rats. The results showed that SM could ameliorate DN by inhibiting oxidative stress induced by AGEs and preventing their binding to the receptor for advanced glycation end products (RAGE), suggesting a promising therapeutic effect in diabetes-related kidney complications.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chi-Heung Cho, Guijae Yoo, Mingyeong Kim, Ulfah Dwi Kurniawati, In-Wook Choi, Sang-Hoon Lee
Summary: The study found that dieckol (DK) isolated from Ecklonia cava has therapeutic potential in improving renal damage in patients with diabetic nephropathy induced by methylglyoxal (MGO). DK exhibits antiglycation properties by inhibiting AGE production, cross-linking formation, and breaking of cross-links. DK also protects renal cells by suppressing intracellular reactive oxygen species (ROS) formation, MGO and AGE accumulation, apoptosis cascade activation, apoptosis-related protein expression, RAGE protein expression, and glyoxalase system suppression. The stronger binding affinity of DK to RAGE than AGE suggests its competitive inhibitory effect on the AGE-RAGE interaction. Thus, DK can be utilized as a potential natural AGE inhibitor for the prevention and treatment of AGE-induced diabetic nephropathy.
Review
Cell Biology
Haruki Watanabe, Myoungsun Son
Summary: The review examines the roles of HMGB1 and RAGE in controlling inflammation and immune tolerance, highlighting the dual effects of the HMGB1-RAGE axis in driving inflammation and its potential anti-inflammatory effects. The discussion also touches on how RAGE heterodimers respond to microenvironments in immune responses.
Article
Biotechnology & Applied Microbiology
Demet Yalcin Kehribar, Mustafa Cihangiroglu, Emine Sehmen, Bahattin Avci, Aylin Capraz, Ayse Yildirim Bilgin, Caner Gunaydin, Metin Ozgen
Summary: COVID-19 patients with higher sRAGE levels tend to be younger and have asymptomatic cases, while patients with lower sRAGE levels are usually older with lung involvement, suggesting the importance of the RAGE pathway in aggravating COVID-19.
Article
Food Science & Technology
Mingyeong Kim, Chiheung Cho, Changjun Lee, Bomi Ryu, Sera Kim, Jinyoung Hur, Sang-Hoon Lee
Summary: This study demonstrated that Ishige okamurae extract (IOE) possesses anti-glycation and renal protective properties by inhibiting formation of advanced glycation end-products (AGEs) in diabetic nephropathy. The bioactive compounds in IOE were found to suppress oxidative stress and apoptosis, suggesting its potential as a natural therapeutic agent for managing AGE-related nephropathy.
Article
Multidisciplinary Sciences
Gao-Xiang Wang, Ze-Bin Fang, Jun-Tong Li, Bao-Li Huang, De-Liang Liu, Shu-Fang Chu, Hui-Lin Li
Summary: This study aimed to investigate the correlation between serum albumin and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). The results showed a significant negative correlation between serum albumin levels and DR, suggesting that serum albumin levels can be used as a reference point for long-term follow-up of patients with T2DM.
Review
Endocrinology & Metabolism
Nayana Khurana, Steven James, Melinda T. Coughlan, Richard J. MacIsaac, Elif Ekinci
Summary: DKD is a growing burden, leading to the discovery of new therapies. Recent clinical trials have shown promising results with SGLT2 inhibitors, incretin-related therapies, and mineralocorticoid receptor antagonists in improving renal outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
James D. Theuerle, Ali H. Al-Fiadh, Edmond Wong, Sheila K. Patel, Gizem Ashraf, Thanh Nguyen, Tien Yin Wong, Francesco L. Ierino, Louise M. Burrell, Omar Farouque
Summary: Endothelial dysfunction is a precursor to atherosclerosis and is associated with the coexistence of CVD and CKD. This study found that retinal arteriolar endothelial dysfunction is present in CVD patients with early-stage CKD and serves as an indicator of long-term CKD progression in those with normal renal function.
Article
Immunology
Chansavath Phetsouphanh, David Darley, Daniel B. Wilson, Annett Howe, C. Mee Ling Munier, Sheila K. Patel, Jennifer A. Juno, Louise M. Burrell, Stephen J. Kent, Gregory J. Dore, Anthony D. Kelleher, Gail Matthews
Summary: Phetsouphanh and colleagues found that individuals with long COVID exhibit persistent activation of the immune system even 8 months after infection. They also identified a set of analytes associated with long COVID, suggesting potential opportunities for prevention and treatment.
Article
Medicine, Research & Experimental
J. M. McGree, C. Hockham, S. Kotwal, A. Wilcox, A. Bassi, C. Pollock, L. M. Burrell, T. Snelling, V. Jha, M. Jardine, M. Jones
Summary: The CLARITY trial is a randomized controlled trial investigating the effectiveness of angiotensin receptor blockers in COVID-19 patients. The trial design is Bayesian adaptive, with the primary outcome being clinical status assessed using a 7-point ordinal scale. The trial will follow the intention-to-treat principle in data analysis.
Article
Immunology
Bruce D. Wines, Liriye Kurtovic, Halina M. Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L. Mordant, Wen Shi Lee, Nicholas A. Gherardin, Sheila K. Patel, Gemma E. Hartley, Phillip Pymm, James P. Cooney, James G. Beeson, Dale Godfrey, Louise M. Burrell, Menno C. van Zelm, Adam K. Wheatley, Amy W. Chung, Wai-Hong Tham, Kanta Subbarao, Stephen J. Kent, P. Mark Hogarth
Summary: Joining a function-enhanced Fc-portion of human IgG to the SARS-CoV-2 entry receptor ACE2 produces an antiviral decoy with strain transcending virus neutralizing activity. Fc-modification was utilized to optimize SARS-CoV-2 neutralization and Fc-effector functions of ACE2-Fc decoy proteins. Different Fc-modifications had distinct effects on neutralization and effector functions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Health Care Sciences & Services
Hui Yin Lim, Louise M. Burrell, Rowena Brook, Harshal H. Nandurkar, Geoffrey Donnan, Prahlad Ho
Summary: Despite advancements in the field of cardiovascular disease, currently available clinical markers and tests are not sufficient to predict individual risk. A more precise and complex tool is needed to predict individual thrombosis and bleeding risks, enabling early interventions with a favorable risk-benefit profile. This review explores the fundamental concept of thrombosis and how personalized risk assessment can be improved using various tools.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Liam Toner, Janet X. C. Chen, Jay Ramchand, Piyush Srivastava, David O'Donnell, Paul Calafiore, Elizabeth Jones
Summary: This study aimed to assess the impact of right ventricular mid-septal pacing on right ventricular function. The results showed that abnormalities in right ventricular strain occurred in some patients one year after pacemaker insertion, indicating potential issues with right ventricular function after atrial pacing.
HEART LUNG AND CIRCULATION
(2023)
Correction
Immunology
Bruce D. Wines, Liriye Kurtovic, Halina M. Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L. Mordant, Wen Shi Lee, Nicholas A. Gherardin, Sheila K. Patel, Gemma E. Hartley, Phillip Pymm, James P. Cooney, James G. Beeson, Dale I. Godfrey, Louise M. Burrell, Menno C. van Zelm, Adam K. Wheatley, Amy W. W. Chung, Wai-Hong Tham, Kanta Subbarao, Stephen J. Kent, P. Mark Hogarth
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Merlin C. Thomas, Melinda T. Coughlan, Mark E. Cooper
Summary: Recent clinical trials have shown that GLP-1RAs can have positive effects on heart and kidney outcomes in people with type 2 diabetes. This is due in part to improved glucose control and significant weight loss, but GLP-1RAs may also provide additional benefits by improving postprandial dysmetabolism.
Review
Biochemistry & Molecular Biology
Inez A. A. Trambas, Melinda T. T. Coughlan, Sih Min Tan
Summary: Diabetic kidney disease (DKD) affects a significant percentage of patients with diabetes and is the leading cause of end-stage renal disease (ESRD). The activation of the complement cascade, a component of the innate immune system, has been implicated in the development of diabetes and its complications. Inhibition of the complement system, particularly at the level of the C5a-receptor signaling axis, shows promise in reducing inflammation and fibrosis in DKD. This review discusses the role of the C5a/C5a-receptor axis in the pathogenesis of diabetes and kidney injuries, as well as the current status and mechanisms of action of complement therapeutics in development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anesthesiology
Tim G. Coulson, Lachlan F. Miles, Alex Zarbock, Louise M. Burrell, Sheila K. Patel, Thilo von Groote, David Pilcher, Laurence Weinberg, Giovanni Landoni, Rinaldo Bellomo
Summary: Compared with norepinephrine, angiotensin II infusion can suppress renin release while maintaining aldosterone levels, providing a potential treatment for vasoplegia after cardiac surgery. Plasma renin concentration before surgery is associated with vasopressor requirement for norepinephrine but not angiotensin II.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Meeting Abstract
Peripheral Vascular Disease
Sheila K. Patel, Carolina Restrepo, Mohamed Khlif, Emilio Werden, Jay Ramchand, Piyush M. Srivastava, Richard J. MacIsaac, Elif I. Ekinci, Louise M. Burrell, Amy Brodtmann
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Nicholas Alexander Doumtsis, Sheila Patel, Jay Ramchand, Ken Lu, Piyush Srivastava, Louise Burrell
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Lebo F. Gafane-Matemane, Louise M. Burrell, Sheila K. Patel, Ruan Kruger, Aletta E. Schutte
JOURNAL OF HYPERTENSION
(2023)
Article
Chemistry, Analytical
John A. Adegoke, Callum Gassner, Varun J. Sharma, Sheila K. Patel, Louise Jackett, Isaac O. Afara, Jaishankar Raman, Louise M. Burrell, Bayden R. Wood
Summary: This study demonstrates that a portable handheld near-infrared spectrometer coupled with machine learning algorithms can effectively differentiate between kidney and cardiac fibrosis in a rat model of kidney failure, providing a potential intraoperative surgical tool for detecting and quantifying fibrosis in the heart and kidney.
ANALYSIS & SENSING
(2023)