Review
Pharmacology & Pharmacy
Li-Xia Yu, Sha-Sha Li, Min-Yue Sha, Jia-Wei Kong, Jian-Ming Ye, Qi-Feng Liu
Summary: This article discusses the clinical significance of Klotho and its potential as a biomarker in chronic kidney disease (CKD). However, there is inconsistent and contradictory evidence regarding the relationship between Klotho and CKD, and a consensus has not been reached. The authors systematically assess the areas of controversy and highlight future directions to resolve inconsistencies and clarify the role of Klotho in CKD clinical practice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medical Laboratory Technology
Omid Babania, Saeed Mohammadi, Esmat Yaghoubi, Ahmad Sohrabi, Fakhri Sadat Seyedhosseini, Nafiseh Abdolahi, Yaghoub Yazdani
Summary: The study found that CD patients have more M2 monocytes and a disturbed cytokine balance. This suggests that these immunological markers could serve as specific diagnostic biomarkers for CD.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Cell Biology
Xiaomin Cai, Wenjin Qiu, Mengshu Qian, Shuang Feng, Chenghao Peng, Jiale Zhang, Yi Wang, Yuhai Wang
Summary: CFI is overexpressed in glioma and is associated with poor outcomes, serving as a potential prognostic biomarker and driving malignant progression in glioma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Claudio Ponticelli, Gabriella Moroni, Francesco Reggiani
Summary: Autosomal-Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder caused by mutations in PKD1 or PKD2 genes. The involvement of autophagy in ADPKD remains a subject of investigation, with potential implications on cyst formation and fibrosis. Autophagy inducers have shown promising results in preclinical studies and may provide a potential avenue for future investigations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Weikang Xu, Xinyu Lu, Jing Liu, Qianhui Chen, Xuan Huang, Kuiyuan Huang, Hongyan Liu, Wei Zhu, Xiaoyong Zhang
Summary: PAFAH1B3 expression is significantly increased in HCC patients, and high expression is associated with poorer overall survival and disease-free survival. PAFAH1B3 may be involved in HCC through cell cycle, cell metabolism, spliceosome, and RNA transport. Inhibiting PAFAH1B3 impairs HCC cell proliferation, invasion, and migration, while downregulating glycolysis and lipid synthesis pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xiaoqin Xu, Xin Yang, Xue Liu, Yanghui Bi, Pengzhou Kong, Yanqiang Wang, Xiaolong Cheng, Yanfeng Xi
Summary: The expression of DBR1 in ESCC tissue was found to be correlated with clinical parameters and patient survival, suggesting that abnormal RNA metabolism may play a critical role in promoting the progression of ESCC.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Pharmacology & Pharmacy
Kosuke Saito, Rika Ishikawa, Isao Kitamura, Kumiko Ogawa, Noriaki Arakawa, Yuchen Sun, Kazuo Imai, Takuya Maeda, Yoshiro Saito, Chihiro Hasegawa
Summary: Serum serotonin levels were found to be decreased in COVID-19 patients with more severe disease, along with increased kynurenine and decreased tryptophan concentrations. Lower serotonin concentrations were associated with subsequent worsening of moderate disease, suggesting it may be a valuable biomarker for disease severity and prognosis.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Ahsan Alam, Emilie Cornec-Le Gall, Ronald D. Perrone
Summary: This article describes autosomal dominant polycystic kidney disease, its signs and symptoms, diagnosis, and treatment options.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Urology & Nephrology
Sita Arjune, Martin R. Spaeth, Simon Oehm, Polina Todorova, Stefan J. Schunk, Katharina Lettenmeier, Seung-Hun Chon, Malte P. Bartram, Philipp Antczak, Franziska Grundmann, Danilo Fliser, Roman-Ulrich Mueller
Summary: In this study, the researchers investigated whether DKK3 could improve outcome prediction in ADPKD. The results demonstrated that ADPKD patients had significantly higher uDKK3 levels, and uDKK3 correlated positively with the Mayo classification and kidney function. Although the effect was no longer significant in multivariate regression analysis adjusting for other factors, adding copeptin levels and the interaction term between copeptin and uDKK3 to the model improved the variance explanation of eGFR slope. Future studies are needed to confirm these findings, but uDKK3 appears to be an attractive candidate for improving outcome prediction in ADPKD.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Adriana Gregory, Fouad T. Chebib, Bhavya Poudyal, Heather L. Holmes, Alan S. L. Yu, Douglas P. Landsittel, Kyongtae T. Bae, Arlene B. Chapman, Rahbari-Oskoui Frederic, Michal Mrug, William M. Bennett, Peter C. Harris, Bradley J. Erickson, Vicente E. Torres, Timothy L. Kline
Summary: New image-derived biomarkers are needed to improve the management of autosomal dominant polycystic kidney disease. A new technique to individually segment cysts and quantify biometric parameters has been developed. Total cyst number and cyst parenchyma surface area showed superior prediction of kidney function decline and disease stages compared to the measurement of total kidney volume.
KIDNEY INTERNATIONAL
(2023)
Article
Oncology
Gaoming Wang, Ludi Yang, Jinli Gao, Huiling Mu, Yanxiang Song, Xiaohua Jiang, Bo Chen, Ran Cui
Summary: High expression of ASXL2 in pancreatic cancer is associated with poor overall survival and is mainly involved in inflammatory response and epithelial mesenchymal transition. Patients with high ASXL2 expression are more likely to benefit from certain treatment modalities such as immune checkpoint blockade and specific chemotherapeutic drugs.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Maike Getwan, Anselm Hoppmann, Pascal Schlosser, Kelli Grand, Weiting Song, Rebecca Diehl, Sophie Schroda, Florian Heeg, Konstantin Deutsch, Friedhelm Hildebrandt, Ekkehart Lausch, Anna Kottgen, Soeren S. Lienkamp
Summary: Using CRISPR/Cas9 mutagenesis, researchers established models for skeletal ciliopathies in Xenopus tropicalis and identified Ttc30a as a key gene related to known skeletal ciliopathy genes, with loss of Ttc30a leading to limb deformities and renal cysts. The study revealed TTC30A/B as essential nodes in the network of ciliary chondrodysplasia and nephronophthisis-like disease proteins.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Chengdong Qin, Siyuan Liu, Shiqi Zhou, Qibo Wang, Xianghou Xia, Jiejie Hu, Xiaohong Yuan, Zongping Wang, Yang Yu, Dening Ma
Summary: PIK3C2A expression is decreased in various tumors, particularly in renal clear cell carcinoma (KIRC). It is significantly correlated with tumor stage, grade, and other clinicopathological features in KIRC. PIK3C2A serves as a potential biomarker for tumor progression and is associated with immune infiltration in KIRC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Chunxiu Yang, Jingjing Pang, Jian Xu, He Pan, Yueying Li, Huainian Zhang, Huan Liu, Shu-Yuan Xiao
Summary: Our study revealed that LRRK2 plays a crucial role in the tumorigenesis and progression of ccRCC, and may serve as a potential predictor and therapeutic target for this type of cancer. The up-regulation of LRRK2 in ccRCC was found to be correlated with DNA methylation and associated with a better prognosis in patients with ccRCC.
CANCER CELL INTERNATIONAL
(2021)
Review
Urology & Nephrology
Fouad T. Chebib, Kristen L. Nowak, Michel B. Chonchol, Kristen Bing, Ahmad Ghanem, Frederic F. Rahbari-Oskoui, Neera K. Dahl, Michal Mrug
Summary: This review discusses the efficacy and safety of dietary interventions, such as caloric restriction, intermittent fasting, and ketogenic diet, in managing ADPKD. These interventions show promise in improving metabolic health and reducing oxidative stress in ADPKD, but limited clinical evidence supports their effectiveness.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Immunology
Madhulika Sharma, Shannon Callen, Da Zhang, Pravin C. Singhal, Gregory B. Vanden Heuvel, Shilpa Buch
Article
Reproductive Biology
Melissa R. Kroll, Engela S. Viss, Jonathan Lamb, Joy Horstman, Alexander Powell, Andrea Van Wyk, Kaarlo Hinkkala, Traci Hoogland, Matthew Schippers, Stephen Shannon, Carol G. Carlton, Madhulika Sharma, Aaron Taylor, Gregory B. Vanden Heuvel, Tony N. Jelsma
BIOLOGY OF REPRODUCTION
(2011)
Article
Developmental Biology
Angelo Iulianella, Madhulika Sharma, Greg B. Vanden Heuvel, Paul A. Trainor
Article
Anatomy & Morphology
Binu M. Paul, Dianne Vassmer, Aaron Taylor, Lynn Magenheimer, Carol G. Carlton, Klaus B. Piontek, Gregory G. Germino, Gregory B. Vanden Heuvel
DEVELOPMENTAL DYNAMICS
(2011)
Review
Biochemistry & Molecular Biology
Neal I. Alcalay, Gregory B. Vanden Heuvel
FRONTIERS IN BIOSCIENCE-LANDMARK
(2009)
Article
Genetics & Heredity
Madhulika Sharma, Jennifer G. Brantley, Dianne Vassmer, Gaurav Chaturvedi, Jennifer Baas, Gregory B. Vanden Heuvel
Article
Urology & Nephrology
Neeraj Sharma, Erik B. Malarkey, Nicolas F. Berbari, Amber K. O'Connor, Gregory B. Vanden Heuvel, Michal Mrug, Bradley K. Yoder
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2013)
Review
Developmental Biology
Binu M. Paul, Gregory B. Vanden Heuvel
WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY
(2014)
Article
Multidisciplinary Sciences
Tarak Srivastava, Trupti Joshi, Daniel P. Heruth, Mohammad H. Rezaiekhaligh, Robert E. Garola, Jianping Zhou, Varun C. Boinpelly, Mohammed Farhan Ali, Uri S. Alon, Madhulika Sharma, Gregory B. Vanden Heuvel, Pramod Mahajan, Lakshmi Priya, Yuexu Jiang, Ellen T. McCarthy, Virginia J. Savin, Ram Sharma, Mukut Sharma
Summary: Systemic inflammation in pregnant obese women leads to newborns with lower kidney/body weight ratio, and administering IL-6 to pregnant mice results in newborns with reduced body and kidney weights, suggesting a potential impact of IL-6 on kidney development in newborns.
SCIENTIFIC REPORTS
(2021)
Article
Physiology
Binu Porath, Safia Livingston, Erica L. Andres, Alexandra M. Petrie, Joshua C. Wright, Anna E. Woo, Carol G. Carlton, Richard Baybutt, Gregory B. Vanden Heuvel
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2017)
Article
Physiology
Madhulika Sharma, Lynn K. Magenheimer, Trisha Home, Karen N. Tamano, Pravin C. Singhal, Deborah P. Hyink, Paul E. Klotman, Gregory B. Vanden Heuvel, Timothy A. Fields
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2013)
Article
Physiology
Neal I. Alcalay, Madhulika Sharma, Dianne Vassmer, Brandon Chapman, Binu Paul, Jing Zhou, Jennifer G. Brantley, Darren P. Wallace, Robin L. Maser, Gregory B. Vanden Heuvel
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2008)
Article
Anatomy & Morphology
Neal I. Alcalay, Jennifer G. Brantley, Madhulika Sharma, Jennifer L. Gooch, Gregory B. Vanden Heuvel
DEVELOPMENTAL DYNAMICS
(2007)
Article
Developmental Biology
Gregory B. Vanden Heuvel, John A. Payne, Peter Igarashi, Bliss Forbush
GENE EXPRESSION PATTERNS
(2006)
