Journal
KIDNEY INTERNATIONAL
Volume 77, Issue 10, Pages 841-843Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ki.2010.20
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- Intramural NIH HHS Funding Source: Medline
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Cytotoxic effects of some therapeutic drugs, including those used for antibacterial treatment, can involve mitochondria by inducing their permeabilization, followed by cell death and organ malfunctioning. This suggests that a strategy to preserve tissue mitochondria could preserve normal organ functioning. Morales et al. reveal that the antidiabetic drug metformin prevents gentamicin-induced nephropathy through a mitochondria-dependent pathway, normalizing oxidative stress and restoring mitochondrial functional integrity. Kidney International (2010) 77, 841-843. doi:10.1038/ki.2010.20
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