Review
Biochemistry & Molecular Biology
Fulvia Zappulo, Maria Cappuccilli, Alessandra Cingolani, Anna Scrivo, Anna Laura Croci Chiocchini, Miriam Di Nunzio, Chiara Donadei, Marianna Napoli, Francesco Tondolo, Giuseppe Cianciolo, Gaetano La Manna
Summary: Vitamin D plays a crucial role in bone metabolism, as well as having important extra-bone effects such as glucose homeostasis and cardiovascular protection. This narrative review provides an overview of the role of vitamin D in different settings, with a special focus on chronic kidney disease and kidney transplant.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Ola Hysaj, Patricia Marques-Gallego, Aline Richard, Magdeldin Elgizouli, Alexandra Nieters, Katharina C. Quack Lotscher, Sabine Rohrmann
Summary: This study assessed parathyroid hormone concentrations in pregnant women during early and late pregnancy, finding an inverse correlation between serum 25(OH)D and PTH levels. Statistically significant determinants of PTH concentrations included 25(OH)D levels, season, parity, and partner's education in early pregnancy, while late pregnancy was affected by 25(OH)D levels and country of origin. These factors seem to primarily impact PTH through 25(OH)D, but may also have other mechanisms of influence.
Review
Nutrition & Dietetics
Vincent Brandenburg, Markus Ketteler
Summary: This review examines the developments of vitamin D therapies in CKD patients and discusses the association between vitamin D deficiency and sHPT as well as its impact on important clinical outcomes in CKD patients. However, vitamin D therapy also comes with the risk of side effects, so it is necessary to address core issues regarding PTH target levels, optimal vitamin D levels, and the effectiveness of sHPT treatment in CKD patients.
Article
Nutrition & Dietetics
Anna Regalia, Matteo Benedetti, Silvia Malvica, Carlo Alfieri, Mariarosaria Campise, Donata Cresseri, Maria Teresa Gandolfo, Federica Tripodi, Giuseppe Castellano, Piergiorgio Messa
Summary: In kidney transplanted patients, those with SARS-CoV-2 infection had lower levels of 25(OH)D compared to controls, but there was no significant association between vitamin D status and severity or outcomes of the infection.
Article
Immunology
Yang-Juan Bai, Ya-Mei Li, Shu-Meng Hu, Yuan-Gao Zou, Yun-Fei An, Lan-Lan Wang, Yun-Ying Shi
Summary: This study aimed to explore the anti-inflammatory effect of vitamin D supplementation in kidney transplant recipients (KTRs) and its role in improving and protecting graft function. The results showed that vitamin D supplementation effectively increased the levels of vitamin D in KTRs and significantly improved renal function after transplantation. Furthermore, vitamin D supplementation also reduced the levels of inflammatory cytokines, thereby reducing the risk of chronic allograft dysfunction.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Dan Alexandru Niculescu, Laura Georgiana Deacu, Andra Caragheorgheopol, Nicoleta Popescu, Adina Ghemigian, Camelia Procopiuc, Roxana Rosca, Catalina Poiana
Summary: Vitamin D status and renal function independently predict serum parathyroid hormone levels. This study found that declining vitamin D and renal function have additive effects on serum PTH levels in subjects without vitamin D deficiency.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Hope A. Weiler, Wen Hsuan Fu, Maryam Razaghi, Nathalie Gharibeh, Catherine A. Vanstone
Summary: This study found an association between vitamin D deficiency and elevated parathyroid hormone levels in newborn infants. The global consensus recommendation on vitamin D deficiency (<25 nmol/L) aligns better with the threshold at which parathyroid hormone is elevated compared to the definition set by the National Academy of Medicine (<30 nmol/L).
Article
Veterinary Sciences
Dennis E. Jewell, Kiran S. Panickar
Summary: The optimum concentration of vitamin D for dogs is still debated, but a minimum concentration of 100 ng/mL (250 nM) of circulating vitamin D has been suggested for optimal health. The relationship between dietary intake of vitamin D-3 and circulating 25(OH) D in adult dogs has not been well studied. The safe upper limit of vitamin D in dog foods for adult maintenance is 3,200 IU/kg on a dry matter basis, but this guideline was not based on studies of adult maintenance requirements. Understanding the relationship between dietary vitamin D and circulating vitamin D is important for promoting health in dogs.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Nutrition & Dietetics
Rakesh Balachandar, Raghu Pullakhandam, Bharati Kulkarni, Harshpal Singh Sachdev
Summary: This study found that cholecalciferol was more effective than ergocalciferol in improving vitamin D status and regulating PTH levels, regardless of participant demographics, dosage, and vehicle of supplementation.
Article
Nutrition & Dietetics
Malgorzata Kluch, Patrycja Bednarkiewicz, Magdalena Orzechowska, Piotr Grzelak, Ilona Kurnatowska
Summary: This study evaluated the intake of vitamin K1 and K2 in the diet of patients in the late period after kidney transplantation. The results showed that the intake of vitamin K1 was adequate, while the intake of vitamin K2 seemed insufficient.
Article
Endocrinology & Metabolism
Makoto Tsujita, Yohei Doi, Yoshitsugu Obi, Takayuki Hamano, Toshihide Tomosugi, Kenta Futamura, Manabu Okada, Takahisa Hiramitsu, Norihiko Goto, Yoshitaka Isaka, Asami Takeda, Shunji Narumi, Yoshihiko Watarai
Summary: The study found that cholecalciferol significantly reduced PTH levels and attenuated LS BMD loss after kidney transplantation, especially showing a more pronounced effect in patients with low bone mass.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Jacklyn N. Hellwege, Xiangzhu Zhu, Xiang Huang, Martha J. Shrubsole, Lei Fan, Bingshan Li, Reid Ness, Douglas L. Seidner, Edward L. Giovannucci, Todd L. Edwards, Qi Dai
Summary: Optimal 25(OH)D levels are associated with a significantly reduced risk of colorectal cancer, particularly among women. Individuals with BPRVID are at higher risks of incident adenoma and colorectal cancer compared to those with HPRVID, especially among women. Treatment strategies should be tailored based on individuals' different response types.
CLINICAL NUTRITION
(2021)
Review
Urology & Nephrology
Mario Cozzolino, Paola Minghetti, Pierluigi Navarra
Summary: A high percentage of chronic kidney disease patients have low vitamin D levels, which can lead to secondary hyperparathyroidism. Early intervention to restore vitamin D levels is recommended to prevent/delay secondary hyperparathyroidism. Controlling parathyroid hormone levels becomes a major focus of therapy for patients with intermediate-stage chronic kidney disease.
JOURNAL OF NEPHROLOGY
(2022)
Article
Pharmacology & Pharmacy
Qing Hao, Yun Qin, Wanjun Zhao, Lingyun Zhang, Han Luo
Summary: The study suggests that supplying calcitriol based on a 70% RDP cutoff may be a wise practice in thyroidectomy patients, helping to stratify high-risk patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Orthopedics
Z. Qu, F. Yang, Y. Yan, J. Huang, J. Zhao, J. Hong, S. Li, G. Jiang, W. Wang, S. Yan
Summary: This study indicated an inverse causal relationship between serum PTH concentrations and development of OA, especially knee OA, but no evidence of the causal effect of serum 25(OH)D levels on OA was found. Further investigation is needed to explore potential mechanisms by which serum PTH affects OA.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Cardiac & Cardiovascular Systems
Laurent Chouchana, Nathanael Beeker, Nicolas Garcelon, Bastien Rance, Nicolas Paris, Elisa Salamanca, Elisabeth Polard, Anita Burgun, Jean-Marc Treluyer, Antoine Neuraz
Summary: Among Covid-19 patients with hypertension, there is a lower mortality rate among those using calcium channel blockers and beta-blockers, while there is no significant association between the use of renin-angiotensin-aldosterone system inhibitors and in-hospital death risk.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Surgery
Antoine Morel, Sandrine Imbeaud, Anne Scemla, Helene Pere, Jacques Fourgeaud, Lucile Amrouche, Nicolas Robillard, Delphine Planas, Julien Puech, Sylvie Simon, Fanny Lanternier, Laurent Belec, Julien Zuber, Olivier Schwartz, Dany Anglicheau, Nathalie Chavarot, David Veyer
Summary: Immunocompromised patients may experience prolonged viral shedding after their initial SARS-CoV-2 infection, however, symptomatic relapses after remission currently remain rare. We herein describe a severe COVID-19 relapse case of a kidney transplant recipient (KTR) following rituximab therapy, 3 months after a moderate COVID-19 infection, despite viral clearance after recovery of the first episode. The diagnosis was established on a broncho-alveolar lavage specimen (BAL) by RT-PCR and confirmed on a cell culture assay. Whole genome sequencing revealed an identical strain (Clade 20A) with acquired mutations located within the N-terminal domain, which may play a role in viral entry. The diagnosis of COVID-19 relapse should be considered in unexplained persistent fever and/or respiratory symptoms in KTRs, especially those who have received rituximab therapy, even with previous negative naso-pharyngeal SARS-CoV-2 PCR results.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Genetics & Heredity
Nicolas Corniere, R. Brent Thomson, Stephanie Thauvin, Bruno O. Villoutreix, Sophie Karp, Diane W. Dynia, Sarah Burlein, Lennart Brinkmann, Alaa Badreddine, Aurelie Dechaume, Mehdi Derhourhi, Emmanuelle Durand, Emmanuel Vaillant, Philippe Froguel, Regine Chambrey, Peter S. Aronson, Amelie Bonnefond, Dominique Eladari
Summary: Nephrolithiasis is a complex disease affecting a significant portion of the global population, and a rare mutation in the SLC26A6 gene has been identified to be associated with hyperoxaluria, affecting oxalate transport and potentially leading to the formation of calcium oxalate stones.
JOURNAL OF MEDICAL GENETICS
(2022)
Article
Health Care Sciences & Services
Astrid Chevance, Axel Fortel, Adeline Jouannin, Faustine Denis, Marie-France Mamzer, Philippe Ravaud, Stephanie Sidorkiewicz
Summary: Digital pills face limitations in prospective acceptability and willingness to use, primarily due to clinical and ethical concerns. Results indicate that willingness to take digital pills is associated with gender and the current use of connected devices to record health settings.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Letter
Urology & Nephrology
Nathalie Chavarot, Clea Melenotte, Lucile Amrouche, Claire Rouzaud, Rebecca Sberro-Soussan, Juliette Pavie, Frank Martinez, Anne Pouvaret, Marianne Leruez-Ville, Delphine Cantin, Jacques Fourgeaud, Claire Delage, Damien Vimpere, Marie Noelle Peraldi, Christophe Legendre, Fanny Lanternier, Julien Zuber, Anne Scemla, Dany Anglicheau
KIDNEY INTERNATIONAL
(2022)
Editorial Material
Immunology
Yongxia Wu, Julien Zuber, Jianing Fu
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Ethics
Alban Zarzavadjian Le Bian, Louis Pantel, Christophe Tresallet, Marie-France Mamzer
Summary: Ethics is a unique field of research for surgeons due to the aggressive nature of surgery. However, the interest in researching medical ethics can be explained through a comparison to thermodynamics, specifically entropy. Entropy represents the wasted energy that exists in medical practice, which justifies the need for research in medical ethics.
PHILOSOPHY ETHICS AND HUMANITIES IN MEDICINE
(2022)
Letter
Surgery
Nathalie Chavarot, Michael Padden, Lucile Amrouche, Stephanie Malard, Anne Scemla, Rebecca Sberro-Soussan, Juliette Leon, Christophe Legendre, Jean Paul Duong, Julien Zuber, Dany Anglicheau, Marion Rabant, Pierre Isnard
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Oncology
Caroline Despres, Marie-France Mamzer
Summary: The study found that patients have difficulty understanding complex information during the process of informed consent for tumor sample collection due to emotional impact of diagnosis, as well as the impact of doctor-patient relationships on patient autonomy in decision-making. The focus group of individuals in poverty situations reported difficulties understanding complex medical terms and a lack of essential information such as risks and data sharing.
BULLETIN DU CANCER
(2022)
Editorial Material
Oncology
Celeste Lebbe, Lucie Biard, Julie Delyon, Julien Zuber
Editorial Material
Ophthalmology
Antoine Morel, Amina Chahrazed Debieb, David Mrejen, Lucile Amrouche, Anne Scemla, Estelle Vilain, Christophe Legendre, Dany Anglicheau, Julien Zuber, Antoine Brezin, Nathalie Chavarot
Summary: This case report describes a kidney transplant recipient who developed anterior and intermediate uveitis with CMV infection under belatacept therapy. CMV infection was confirmed using polymerase chain reaction assays. Belatacept therapy was interrupted and medication treatments were initiated, leading to successful control of inflammation.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Urology & Nephrology
Steicy Sobrino, Chrystelle Abdo, Benedicte Neven, Adeline Denis, Nathalie Gouge-Biebuyck, Emmanuel Clave, Soeli Charbonnier, Tifanie Blein, Camille Kergaravat, Marion Alcantara, Patrick Villarese, Romain Berthaud, Laurene Dehoux, Souha Albinni, Esma Karkeni, Chantal Lagresle-Peyrou, Marina Cavazzana, Remi Salomon, Isabelle Andre, Antoine Toubert, Vahid Asnafi, Capucine Picard, Stephane Blanche, Elizabeth Macintyre, Olivia Boyer, Emmanuell Six, Julien Zuber
Summary: Long-term multilineage hematopoietic donor chimerism can occur in patients who receive a transplanted solid organ with lymphoid tissues, such as the intestine or liver. However, there is currently no evidence for kidney-resident hematopoietic stem cells in any mammal species. In this study, we found that human kidney-derived hematopoietic stem cells can reside in the recipient's bone marrow and replace host counterparts, leading to full donor chimerism of both lymphoid and myeloid lineages.
KIDNEY INTERNATIONAL
(2023)
Article
Oncology
Lucien Lahmi, Marie-France Mamzer, Anita Burgun, Catherine Durdux, Jean -Emmanuel Bibault
Summary: Radiation oncology heavily relies on new technology, and data science and artificial intelligence play an important role in the field. This review discusses the ethical aspects of using artificial intelligence in radiation oncology, explores its impact on work and the field, and presents the challenges ahead.
SEMINARS IN RADIATION ONCOLOGY
(2022)
Review
Hematology
Juliette Leon, Marie-Benedicte LeStang, Rebecca Sberro-Soussan, Aude Servais, Dany Anglicheau, Veronique Fremeaux-Bacchi, Julien Zuber
Summary: Overactivation of the complement alternative pathway is the driving factor in the pathogenesis of primary atypical hemolytic uremic syndrome (aHUS). Dysregulation of the complement is frequently seen in patients with aHUS, pregnancy-related hemolytic uremic syndrome (HUS), and severe hypertension-associated HUS. It is uncertain whether self-limited complement activation in other forms of HUS provides mechanistic clues or is a result of endothelial damage. Novel biomarkers are being developed to establish complement-driven pathogenesis. C5 blockade therapy has significantly improved the management of aHUS patients, while its efficacy in secondary forms of HUS needs further investigation through prospective clinical trials. The increased risk of meningococcal infection due to C5 inhibition must be addressed with appropriate prophylaxis. Treatment duration should be based on an individualized benefit/risk assessment.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Hematology
A. Jouannin, E. Robin, S. Bouvet, A. Chevance, P. Le Douaron, M. Esvan, B. Danic, M. -F. Mamzer, J. -B. Thibert
Summary: This study aimed to develop and validate an awareness raising tool for GPs to increase blood donation. The tool, consisting of elements from different potential tools, was found to be acceptable and preferred by both GPs and patients. The validation process showed a high level of acceptability and willingness to use the tool among GPs.
TRANSFUSION CLINIQUE ET BIOLOGIQUE
(2023)