Review
Biochemistry & Molecular Biology
Stefano Turolo, Alberto Edefonti, Alessandra Mazzocchi, Marie Louise Syren, William Morello, Carlo Agostoni, Giovanni Montini
Summary: Research on the role of arachidonic acid and its metabolites in kidney disease, particularly idiopathic nephrotic syndrome, is limited. These substances play a significant role in various biological processes related to kidney function, inflammation, and fibrosis. Dietary interventions to maintain balance between arachidonic acid and linoleic acid could potentially help mitigate inflammatory states seen in kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Urology & Nephrology
Sanjeev Sethi
Summary: Membranous nephropathy is a disease caused by immune complex deposition along the glomerular basement membrane, with PLA2R and THSD7A being the main antigens. New mass spectrometry techniques have led to the discovery of four novel types of MN, each with distinct clinical and pathologic features. Additional studies are needed to understand the pathophysiology, treatment response, and outcomes of these new MN subtypes.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Pediatrics
Zivile Bekassy, Martin Lindstrom, Therese Rosenblad, Sunna Aradottir, Lisa Sartz, Kjell Tullus
Summary: This study investigated the need for kidney biopsy in children with steroid-sensitive nephrotic syndrome in the Northern European setting. The results showed that kidney biopsy is rarely necessary in steroid-sensitive children without any other complicating factor, and therefore, the liberal policy of kidney biopsy in the Nordic countries can be safely changed.
Article
Urology & Nephrology
Youying Mao, Ronen Schneider, Peter F. M. van der Ven, Marvin Assent, Keerthika Lohanadan, Verena Klambt, Florian Buerger, Thomas M. Kitzler, Konstantin Deutsch, Makiko Nakayama, Amar J. Majmundar, Nina Mann, Tobias Hermle, Ana C. Onuchic-Whitford, Wei Zhou, Nandini Nagarajan Margam, Roy Duncan, Jonathan Marquez, Mustafa Khokha, Hanan M. Fathy, Jameela A. Kari, Sherif El Desoky, Loai A. Eid, Hazem Subhi Awad, Muna Al-Saffar, Shrikant Mane, Richard P. Lifton, Dieter O. Fuerst, Shirlee Shril, Friedhelm Hildebrandt
Summary: The study shows that SYNPO2 variants may lead to Rac1-ARP3 dysregulation, and may play a role in the pathogenesis of nephrotic syndrome.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Endocrinology & Metabolism
Eli Muchtar, Matthew T. Drake, Nelson Leung, Angela Dispenzieri, Martha Q. Lacy, Francis K. Buadi, David Dingli, Suzanne R. Hayman, Prashant Kapoor, Yi Lisa Hwa, Amie Fonder, Miriam Hobbs, Wilson Gonsalves, Taxiarchis Kourelis, Rahma Warsame, Stephen Russell, Ronald S. Go, Moritz Binder, Robert A. Kyle, S. Vincent Rajkumar, Shaji K. Kumar, Morie A. Gertz
Summary: The study found that vitamin D deficiency is common in AL amyloidosis patients, particularly among those with heavy proteinuria. Severe 25(OH)D deficiency at diagnosis predicts progression to end-stage renal disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nicholas A. Maksimowski, Xuewen Song, Eun Hui Bae, Heather Reich, Rohan John, York Pei, James W. Scholey
Summary: The study revealed that FSTL1 is a fibroblast-derived cytokine associated with the progression of chronic kidney disease. Its expression levels are positively correlated with age, eGFR, proteinuria, interstitial fibrosis, and tubular atrophy. High baseline FSTL1 mRNA levels were also linked to a greater risk of clinical disease progression in CKD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Bo Lu, Lilach O. Lerman
Summary: Recent clinical studies indicate that mesenchymal stem cell (MSC) therapy can potentially have positive clinical effects in patients with diabetic nephropathy or nephrotic syndrome, possibly through immunomodulation. These trials suggest the safety of the therapy, but adverse reactions highlight the importance of closely examining the source and functional attributes of MSCs.
NATURE REVIEWS NEPHROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ryosuke Saiki, Kan Katayama, Kaoru Dohi
Summary: Proteinuria is associated with mortality, and nephrotic syndrome is defined by proteinuria and hypoalbuminemia. Genetic kidney diseases have been discovered more frequently with advances in medicine. This review focuses on the study of proteinuria/nephrotic syndrome and other kidney diseases in mouse models, leading to significant progress in understanding genetics and pathophysiology. Future genetic analysis of proteinuric kidney disease/nephrotic syndrome may provide personalized treatment options.
Article
Multidisciplinary Sciences
Emmanuel Kwaku Ofori, Egyam Bill Clinton, Obed Danso Acheampong, Henry Asare-Anane, Seth Kwabena Amponsah, Jayasinghe Su, Seth Dortey Amanquah
Summary: Blood protein leakage, especially albumin, into the urine is a hallmark of nephrotic syndrome (NS). This study found that CRP and gamma globulin can be used as predictors of NS.
Article
Pediatrics
Udo Vester, Augustin Fombah, Maite Hoelscher, Danlami Garba, Mary Tapgun, Pamela Collier N'Jai, Philipp Mendy, Gibril Bass, Abdul K. Muhammad, Suzanne T. Anderson, Abdoulie Sanneh, Charles Onyeama, Udo Helmchen, Khalifa Bojang, Peter F. Hoyer, Tumani Corrah
Summary: Kidney diseases are frequently seen in West Africa, but diagnostic and therapeutic options are limited due to lack of specialized facilities. A study conducted in The Gambia collected clinical data and kidney biopsy results from 121 pediatric and young adult patients with edema and proteinuria. The results showed that post-infectious glomerulonephritis, focal-segmental glomerulosclerosis, minimal change nephrotic syndrome, and membranous glomerulonephritis were the most common underlying histologies. The study also highlighted the importance of clinical histopathological correlation in guiding therapy and the need for further interventional studies in steroid-resistant cases.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Shu-Peng Lin, Feng-Ge Zhu, Jin-Ling Meng, Xiao-Wei Sun, Jing Cui, Shuang Liang, Zhong Yin, Xue-Feng Sun, Guang-Yan Cai
Summary: This study found that the percentage of AKI in patients with minimal change nephropathy is significantly higher than that in patients with membranous nephropathy, and patients over 50 years old are more likely to develop AKI. Renal tubular epithelial cell injury and renal interstitial edema may be the main pathological lesions associated with elevated serum creatinine in patients with minimal change nephropathy.
CHINESE MEDICAL JOURNAL
(2021)
Editorial Material
Urology & Nephrology
Tilman B. Drueke, Ziad A. Massy
Summary: Key contributors to anemia in patients with chronic kidney disease include insufficient erythropoietin production, decreased red blood cell half-life, iron deficiency, and inflammation. Proteinuria may alter erythrocyte metabolism and increase erythrocyte death in these patients.
KIDNEY INTERNATIONAL
(2021)
Review
Medicine, General & Internal
Xuefei Tian, Patricia Bunda, Shuta Ishibe
Summary: Endocytosis is a mechanism that internalizes and recycles plasma membrane components and transmembrane receptors via vesicle formation. Podocytes, specialized epithelial cells in the kidney, play a critical role in maintaining the integrity of the glomerular filtration barrier. Dysfunction of podocyte endocytosis is associated with the development and progression of proteinuria in chronic kidney disease. Understanding the mechanism of podocyte endocytosis may provide insights into maintaining normal filtration function and potential therapeutic strategies for proteinuric glomerular diseases.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Debbie S. Gipson, Jonathan P. Troost, Cathie Spino, Samara Attalla, Joshua Tarnoff, Susan Massengill, Richard Lafayette, Virginia Vega-Warner, Sharon Adler, Patrick Gipson, Matthew Elliott, Frederick Kaskel, Damian Fermin, Marva Moxey-Mims, Richard N. Fine, Elizabeth J. Brown, Kimberly Reidy, Katherine Tuttle, Keisha Gibson, Kevin Lemley, Larry A. Greenbaum, Meredith A. Atkinson, Sangeeta Hingorani, Tarak Srivastava, Christine B. Sethna, Kevin Meyers, Cheryl Tran, Katherine M. Dell, Chia-shi Wang, Jennifer Lai Yee, Matthew G. Sampson, Rasheed Gbadegesin, J. J. Lin, Tammy Brady, Michelle Rheault, Howard Trachtman
Summary: This study examined whether there are differences in kidney health outcomes among children, adolescents, and adults with FSGS, and found that the association of FSGS with kidney survival and functional outcomes was comparable at all ages.
Article
Medicine, General & Internal
Leo Drapeau, Mathilde Beaumier, Julie Esbelin, Francois Comoz, Lucile Figueres, Giorgina Barbara Piccoli, Delphine Kervella
Summary: Pregnant patients with diabetic nephropathy are at risk of rapid kidney function decline. Guidelines for managing early diabetic nephropathy in pregnancy exist, but there is a lack of data for patients with severe nephrotic syndrome and kidney function impairment, making the decision on whether and when to start dialysis uncertain.
JOURNAL OF CLINICAL MEDICINE
(2022)