Review
Pharmacology & Pharmacy
Meifang Zheng, Runping Gao
Summary: This article reviews the mechanisms and potential therapeutic effects of vitamin D and its analogues in the treatment of pancreatic fibrosis, as well as the relationship between vitamin D deficiency and the risk of chronic pancreatitis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Peripheral Vascular Disease
Ahmed Abed, Aurelie S. Leroyer, Panagiotis Kavvadas, Florence Authier, Richard Bachelier, Alexandrine Foucault-Bertaud, Nathalie Bardin, Clemens D. Cohen, Maja T. Lindenmeyer, Magali Genest, Ahmad Joshkon, Noemie Jourde-Chiche, Stephane Burtey, Marcel Blot-Chabaud, Francoise Dignat-George, Christos E. Chadjichristos
Summary: CD146 plays a major role in glomerulonephritis, and its overexpression may lead to renal damage. Knockout or specific deletion of CD146 may have therapeutic potential in reducing glomerular injury and the progression of renal disease.
Article
Peripheral Vascular Disease
Xueling Yue, Limei Piao, Hailong Wang, Zhe Huang, Xiangkun Meng, Takeshi Sasaki, Aiko Inoue, Kae Nakamura, Ying Wan, Shengnan Xu, Guo-Ping Shi, Weon Kim, Toyoaki Murohara, Masafumi Kuzuya, Xian Wu Cheng
Summary: This study found that chronic psychological stress accelerated kidney injury and hypertension caused by nephrectomy, while CatK inhibition could delay these harmful changes. The results demonstrated the essential role of CatK in kidney remodeling and hypertension in response to nephrectomy and stress, providing a novel therapeutic strategy for controlling kidney injury under chronic psychological stress conditions.
Article
Immunology
Sophie Carina Kunte, Julian A. Marschner, Martin Klaus, Tamisa Honda, Chenyu Li, Manga Motrapu, Christoph Walz, Maria Lucia Angelotti, Giulia Antonelli, Maria Elena Melica, Letizia De Chiara, Roberto Semeraro, Peter J. Nelson, Hans-Joachim Anders
Summary: This study demonstrated through single-cell transcriptome analysis and experiments that NLRP3 inflammasome expression in renal parenchymal cells is low or even nonexistent, and podocytes do not produce IL-1β and IL-18. Therefore, NLRP3-mediated glomerular inflammation is limited to immune cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yicheng Ge, Jing Luo, Dan Li, Chenxi Li, Junkai Huang, Haoyue Yu, Xinyi Lin, Yingxi Li, Maoqiang Man, Junling Zhang, Jing Zhang, Lizhi Hu
Summary: This study demonstrates that the ablation of VDR in keratinocytes greatly exacerbates dermal fibrosis in HOCl-induced scleroderma in mice, suggesting that the interplay between keratinocytes and fibroblasts plays a crucial role in the pathogenesis and treatment of scleroderma.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Michele Santiago dos Santos, Daniele Canale, Desiree Rita Denelle Bernardo, Maria Heloisa Massola Shimizu, Antonio Carlos Seguro, Rildo Aparecido Volpini, Ana Carolina de Braganca
Summary: Maintaining adequate levels of vitamin D can improve renal function, reduce inflammation and fibrotic lesions, and may serve as a therapeutic alternative in mitigating renal disease progression.
FRONTIERS IN MEDICINE
(2021)
Article
Endocrinology & Metabolism
Eli Muchtar, Matthew T. Drake, Nelson Leung, Angela Dispenzieri, Martha Q. Lacy, Francis K. Buadi, David Dingli, Suzanne R. Hayman, Prashant Kapoor, Yi Lisa Hwa, Amie Fonder, Miriam Hobbs, Wilson Gonsalves, Taxiarchis Kourelis, Rahma Warsame, Stephen Russell, Ronald S. Go, Moritz Binder, Robert A. Kyle, S. Vincent Rajkumar, Shaji K. Kumar, Morie A. Gertz
Summary: The study found that vitamin D deficiency is common in AL amyloidosis patients, particularly among those with heavy proteinuria. Severe 25(OH)D deficiency at diagnosis predicts progression to end-stage renal disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Domenico Plantone, Guido Primiano, Carlo Manco, Sara Locci, Serenella Servidei, Nicola De Stefano
Summary: Vitamin D has various effects on the nervous system and its deficiency can increase the risk of developing neurological diseases. Recent studies aim to understand the different outcomes of vitamin D supplementation in progressive neurological diseases. This review provides an overview of vitamin D chemistry, metabolism, mechanisms of action, recommended daily intake, and its role in gene transcription and the immune response. The scientific evidence linking low vitamin D concentrations to severe neurological diseases is discussed, and ongoing clinical trials on vitamin D supplementation in neurological diseases are listed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
George Haddad, James Dylewski, River Evans, Linda Lewis, Judith Blaine
Summary: Podocytes play a crucial role in preventing serum proteins from filtering into the urine. Recent evidence suggests that in immune mediated kidney diseases, podocytes are targeted by immune complexes. The mechanisms by which podocytes handle and respond to immune complexes are still unknown.
Article
Chemistry, Multidisciplinary
Tian-tian Wei, Le-tian Yang, Fan Guo, Si-bei Tao, Lu Cheng, Rong-shuang Huang, Liang Ma, Ping Fu
Summary: Activation of GPR120 in podocytes plays a crucial role in ameliorating renal inflammation and fibrosis to protect against DN.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Physiology
Kazuyoshi Yamamoto, Masahiro Okabe, Keiko Tanaka, Takashi Yokoo, Ira Pastan, Toshikazu Araoka, Kenji Osafune, Tomohiro Udagawa, Masahiro Koizumi, Taiji Matsusaka
Summary: This study clarifies why morphologically definitive apoptosis is rarely observed in podocytes in vivo. When caspase-3 is activated in podocytes, these cells are immediately detached from the glomerulus and lost in the urine before DNA fragmentation occurs. Detachment is facilitated by glomerular filtration. This phenomenon explains why podocytes in vivo rarely show TUNEL staining and never apoptotic bodies.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Kamil Grubczak, Aleksandra Starosz, Barbara Makowska, Zuzanna Parfienowicz, Magdalena Kretowska, Beata Naumnik, Marcin Moniuszko
Summary: Minimal change disease (MCD) is a major cause of nephrotic syndrome and affects podocyte function. This study investigated the effects of calcitriol (active vitamin D3) and steroids on podocyte function in an in vitro model. The results showed that neither calcitriol nor steroids affected cell viability, but they had different effects on podocyte-related proteins and morphology. Furthermore, the barrier function of the podocytes was improved with the use of vitamin D3 or steroid.
SCIENTIFIC REPORTS
(2023)
Review
Cardiac & Cardiovascular Systems
Federico Carbone, Luca Liberale, Peter Libby, Fabrizio Montecucco
Summary: Experimental and clinical findings linking vitamin D to cardiovascular risk have prompted consideration of its supplementation for overall health improvement. However, several meta-analyses do not support its clinical effectiveness, and recent research has revealed complex non-classical effects of vitamin D in cardiovascular diseases.
EUROPEAN HEART JOURNAL
(2023)
Review
Nutrition & Dietetics
Alberto Caballero-Garcia, Alfredo Cordova-Martinez, Nestor Vicente-Salar, Enrique Roche, Daniel Perez-Valdecantos
Summary: Vitamin D plays a crucial role in immune modulation, enhancing macrophage functions and modulating muscle inflammatory response and protein synthesis. It is particularly important in cases of deficiency or high muscular demand.
Article
Medicine, Research & Experimental
Kai Yang, Ying Pan, Hao Zhang, Lei Jin, Xian Wang
Summary: This study found that hepatic vitamin D receptor expression is significantly decreased in patients with chronic hepatitis B virus (HBV) infection. Further experiments demonstrated that HBV infection can inhibit the expression of vitamin D receptor in hepatocytes. Mechanistically, HBV induces the expression of miR-125a, which in turn inhibits the expression of VDR. Statistical analysis showed that hepatic VDR expression is significantly negatively correlated with liver inflammation and fibrosis.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Review
Medicine, General & Internal
Guido Gembillo, Rossella Siligato, Valeria Cernaro, Domenico Santoro
JOURNAL OF CLINICAL MEDICINE
(2020)
Editorial Material
Medicine, General & Internal
Domenico Santoro, Guido Gembillo, Giuseppe Ando
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Medicine, General & Internal
Maria Antonietta Barbieri, Michelangelo Rottura, Giuseppe Cicala, Rossella Mandraffino, Sebastiano Marino, Natasha Irrera, Carmen Mannucci, Domenico Santoro, Francesco Squadrito, Vincenzo Arcoraci
JOURNAL OF CLINICAL MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
Guido Gembillo, Valeria Cernaro, Rossella Siligato, Francesco Curreri, Antonino Catalano, Domenico Santoro
Article
Biochemistry & Molecular Biology
Guido Gembillo, Luca Visconti, Maria Ausilia Giusti, Rossella Siligato, Alessia Gallo, Domenico Santoro, Alessandro Mattina
Summary: Cardiorenal syndrome is a multi-organ disease involving complex interactions between the heart and kidney, with the use of specific biomarkers aiding in diagnosis, risk assessment, and prognosis determination.
Review
Medicine, General & Internal
Alessandro Caracciolo, Renato Francesco Maria Scalise, Fabrizio Ceresa, Gianluca Bagnato, Antonio Giovanni Versace, Roberto Licordari, Silvia Perfetti, Francesca Lofrumento, Natasha Irrera, Domenico Santoro, Francesco Patane, Gianluca Di Bella, Francesco Costa, Antonio Micari
Summary: The net benefit of percutaneous coronary intervention (PCI) in patients with chronic kidney disease (CKD) is not well established. However, proper management is crucial to improve outcomes for this patient population, including pre-procedural preparation, reducing contrast usage during the procedure, implementing modern strategies, and personalized antithrombotic therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Guido Gembillo, Vincenzo Labbozzetta, Alfio Edoardo Giuffrida, Luigi Peritore, Vincenzo Calabrese, Claudia Spinella, Maria Rita Stancanelli, Eugenia Spallino, Luca Visconti, Domenico Santoro
Summary: Copper is a crucial element for body homeostasis and its imbalances can lead to various diseases. Both copper deficiency and excessive exposure can cause harm to multiple organs. Particularly, the influence of copper on diabetes and its complications, such as Diabetic Kidney Disease, has been studied extensively.
Review
Nutrition & Dietetics
Valeria Cernaro, Michela Calderone, Guido Gembillo, Vincenzo Calabrese, Chiara Casuscelli, Claudia Lo Re, Elisa Longhitano, Domenico Santoro
Summary: Hyperphosphatemia is a common complication in advanced chronic kidney disease and can lead to cardiovascular morbidity and mortality. This review focuses on the management of phosphatemia in uremic patients receiving peritoneal dialysis. The control of serum phosphate in peritoneal dialysis patients is influenced by various factors such as patient transporter characteristics, peritoneal dialysis modalities, prescriptions, and diet. There is a need for more clinical trials specifically designed for peritoneal dialysis patients to evaluate the effects of multiple therapeutic approaches on serum phosphate control and clinical outcomes.
Review
Medicine, General & Internal
Luigi Peritore, Vincenzo Labbozzetta, Veronica Maressa, Chiara Casuscelli, Giovanni Conti, Guido Gembillo, Domenico Santoro
Summary: Membranous nephropathy is a common autoimmune disease that affects the glomeruli and can lead to nephrotic syndrome and end-stage renal disease. The discovery of autoantibodies has improved our understanding of the disease and guided its diagnosis and treatment. Treatment options include supportive therapy and immunosuppressive drugs, but the choice of treatment should be based on individual patients.
MEDICINA-LITHUANIA
(2023)
Review
Medicine, General & Internal
Michela Amatruda, Guido Gembillo, Alfio Edoardo Giuffrida, Domenico Santoro, Giovanni Conti
Summary: Youth-onset T2DM is a significant global burden with high prevalence rates in China and the United States, driven by genetic factors and coexisting risk factors like obesity and hyperglycemia. Understanding the pathogenesis and treatment evolution of DKD in this population is crucial to reducing the risk of DKD progression.
MEDICINA-LITHUANIA
(2021)
Review
Medicine, General & Internal
Rossella Siligato, Guido Gembillo, Vincenzo Calabrese, Giovanni Conti, Domenico Santoro
Summary: Familial Mediterranean fever is a genetic autoinflammatory disease that can lead to severe complications, with amyloid A renal deposition-induced amyloidosis being the most fearsome. Differential diagnosis of nephrotic syndrome among FMF patients is necessary, and early detection of microalbuminuria is a key signal of kidney impairment.
MEDICINA-LITHUANIA
(2021)
Review
Medicine, General & Internal
Guido Gembillo, Rossella Siligato, Michela Amatruda, Giovanni Conti, Domenico Santoro
Summary: Vitamin D plays a crucial role in Chronic Kidney Disease patients by reducing proteinuria and slowing kidney disease progression. It has anti-inflammatory effects and protects podocytes, contributing to the inhibition of kidney inflammation.
MEDICINA-LITHUANIA
(2021)