Article
Endocrinology & Metabolism
Joao Victor Salgado, Miguel Angelo Goes, Natalino Salgado Filho
Summary: The global nephrology community acknowledges the increasing burden of kidney disease and emphasizes on early diagnosis, understanding of disease progression, and development of new therapeutic interventions. FGF21 is considered a key regulator of lipid, glucose, and energy metabolism, as well as stress responses. While promising results have been shown with FGF21 analogs in metabolic disease, its exact role in kidney function remains poorly understood.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Transplantation
Manuel Alfredo Podesta, David Cucchiari, Paola Ciceri, Piergiorgio Messa, Jose-Vicente Torregrosa, Mario Cozzolino
Summary: Vascular and valvular calcifications are common in kidney transplant recipients and associated with increased risk of cardiovascular events. Despite resolution of uremia-related metabolic derangements, recipients are still exposed to pro-calcifying stimuli, highlighting the need for strategies to correct or minimize their effects.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Clinical Neurology
Dong-Young Lee, Dong Kyun Yoo, Sang Youb Han, Kangbaek Lee, Young Lee, Kayla M. Teopiz, Rodrigo B. Mansur, Joshua D. Rosenblat, Roger S. McIntyre
Summary: This study aimed to evaluate the etiology of CKD and comorbid depression by investigating bone disorders that are observed in persons affected by both CKD and depression. The results showed that depressive symptoms in CKD patients were associated with low bone density.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Cardiac & Cardiovascular Systems
Ashton C. Lai, Solomon W. Bienstock, Raman Sharma, Karl Skorecki, Frans Beerkens, Rajeev Samtani, Andrew Coyle, Tonia Kim, Usman Baber, Anton Camaj, David Power, Valentin Fuster, Martin E. Goldman
Summary: Cardiovascular disease is the leading cause of death in end-stage renal disease patients, exacerbated by dialysis treatment. Multimodality imaging may offer additional prognostication and risk stratification for these patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Endocrinology & Metabolism
K. David, V Dubois, A. Verhulst, V Sommers, D. Schollaert, L. Deboel, K. Moermans, G. Carmeliet, P. D'Haese, D. Vanderschueren, F. Claessens, P. Evenepoel, B. Decallonne
Summary: Patients with chronic kidney disease (CKD) often suffer from bone loss and arterial calcifications. This study aimed to investigate the role of hypogonadism in these complications and the potential of androgen therapy in prevention. Male rats with CKD were treated with testosterone or dihydrotestosterone (DHT), while a control group received vehicle. CKD animals exhibited higher levels of serum creatinine and parathyroid hormone, as well as lower levels of testosterone. Androgen treatment restored testosterone levels and organ weights, but did not prevent bone loss or arterial calcifications, especially in the presence of severe hyperparathyroidism.
JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Federica Bellone, Maria Cinquegrani, Ramona Nicotera, Nazareno Carullo, Alessandro Casarella, Pierangela Presta, Michele Andreucci, Giovanni Squadrito, Giuseppe Mandraffino, Marcello Prunesti, Cristina Vocca, Giovambattista De Sarro, Davide Bolignano, Giuseppe Coppolino
Summary: Chronic kidney disease (CKD) is often associated with vitamin K deficiency, which plays a crucial role in the progression of CKD and the development of bone and cardiovascular complications. Vitamin K supplementation may be beneficial in preventing these CKD complications, but further clinical studies are needed to determine safety and appropriate dosage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Camilla Nordheim Solli, Sandra Chamat-Hedemand, Hanne Elming, Anh Ngo, Lasse Kjaer, Vibe Skov, Anders Lindholm Sorensen, Christina Ellervik, Andreas Fuchs, Per Ejlstrup Sigvardsen, Jorgen Tobias Kuhl, Klaus Fuglsang Kofoed, Borge G. Nordestgaard, Hans Hasselbalch, Niels Eske Bruun
Summary: This study investigated whether patients with Philadelphia-negative Myeloproliferative Neoplasms (MPNs) have an increased burden of cardiac calcification and found that MPNs patients have a higher prevalence of coronary artery calcium score (CACS) and aortic valve calcification (AVC) compared to the general population. This association remains significant after adjusting for cardiovascular risk factors.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Plant Sciences
Linna Liu, Lei Wang, Li Li, Hong Wang, Ling Yuan, Li Kang, Qian Jiang, Guan Chen, Nan Lv, Xiaoxue Cui, Lin Huang, Huifei Wu, Juan Xu, Yanlin Li
Summary: Triangle grass, a perennial herb mainly distributed in Guangdong and Guangxi Provinces of China, is used for treating bone pain and swelling. It has analgesic, anti-inflammatory, anti-snake venom, and microcirculation improvement properties and has been shown to improve bone metabolism disorder in CKD-MBD rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Sowmya Swamy, Sahibzadi Mahrukh Noor, Roy O. Mathew
Summary: Chronic kidney disease (CKD) is common in patients with diabetes mellitus (DM), increasing the risk for cardiovascular disease (CVD). Glycemic control has the best evidence for preventing CKD development, while inhibition of the renin-angiotensin system (RASI) helps slow down CKD progression. Sodium glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide receptor agonists (GLP1RA) have shown promising results in reducing mortality, heart failure hospitalizations, and worsening CKD in patients with diabetes and CKD. Combining evidence-based therapies may further minimize CVD events.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Francisco Javier Manzano-Lista, Marta Sanz-Gomez, Daniel Gonzalez-Moreno, Elena Vega-Martin, Marta Gil-Ortega, Angela Schulz, Miguel Angel Rubio, Gema Ruiz-Hurtado, Luis Miguel Ruilope, Isabel Aranguez, Reinhold Kreutz, Maria S. Fernandez-Alfonso
Summary: Arterial stiffness is a common complication in patients with chronic kidney disease (CKD). Imbalance between BMP-2 and BMP-7 may contribute to the development of kidney damage, hypertension, and increased pulse wave velocity (PWV) in CKD patients. This study found that BMP-2 levels were higher, while BMP-7 levels were lower in CKD patients compared to controls, and this imbalance was associated with higher blood pressure and PWV. The expression of related proteins in kidney and perivascular adipose tissues (PVAT) was also abnormal, indicating a potential role in vascular damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Maren Goetz, Mitho Mueller, Raphael Gutsfeld, Tjeerd Dijkstra, Kathrin Hassdenteufel, Sara Yvonne Brucker, Armin Bauer, Stefanie Joos, Miriam Giovanna Colombo, Sabine Hawighorst-Knapstein, Ariane Chaudhuri, Gudula Kirtschig, Frauke Saalmann, Stephanie Wallwiener
Summary: Observational cohort study in Germany found that preterm delivery and preeclampsia are independent risk factors for chronic kidney disease in women, with a significantly increased risk for severe CKD when both conditions are present together.
SCIENTIFIC REPORTS
(2021)
Review
Biology
Carlo Maria Barbagallo, Angelo Baldassare Cefalu, Antonina Giammanco, Davide Noto, Rosalia Caldarella, Marcello Ciaccio, Maurizio Rocco Averna, Emilio Nardi
Summary: Chronic kidney disease is an important risk factor for cardiovascular disease, with dyslipidemia often present in patients with CKD. Various lipoprotein abnormalities occur due to impaired enzymes pathways and proteins involved in lipoprotein metabolism in CKD patients. Hypolipidemic treatments may alter the progression of CVD in CKD patients.
Article
Urology & Nephrology
Hyoungnae Kim, Joongyub Lee, Kyu-Beck Lee, Yeong-Hoon Kim, Namki Hong, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Kyu Hun Choi, Kook-Hwan Oh, Tae-Hyun Yoo
Summary: The study found a significant association between low bone mineral density and the progression of coronary arterial calcification, as well as the risk of major adverse cardiovascular events in patients with predialysis chronic kidney disease.
CLINICAL KIDNEY JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Joanna Tracz, Magdalena Luczak
Summary: Patients with chronic kidney disease (CKD) face a higher risk of atherosclerosis and premature mortality due to cardiovascular events. The well-known risk factors for classical atherosclerosis do not fully explain the high prevalence of atherosclerosis in CKD. The complexity of the molecular mechanisms underlying the acceleration of CKD-related atherosclerosis remains to be fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Ezequiel Bellorin-Font, Eudocia Rojas, Kevin J. Martin
Summary: Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) involves alterations in calcium, phosphorus, parathyroid hormone (PTH), Vitamin D, and fibroblast growth factor-23 (FGF-23) metabolism, leading to bone fractures and vascular disease. The bone component of CKD-MBD, known as renal osteodystrophy, starts early during CKD progression. Factors such as osteoporosis may also contribute to the risk of bone fracture. After kidney transplantation, these bone alterations may persist, progress, or transform due to new pathogenetic mechanisms. This study reviews the bone lesions that occur during CKD and after kidney transplant.