Review
Cardiac & Cardiovascular Systems
Giorgio Benatti, Felice Gragnano, Luigi Vignali, Paolo Calabro, Filippo Luca Gurgoglione, Giampaolo Niccoli
Summary: Approximately half of the patients with ST-segment elevation myocardial infarction have additional atherosclerotic lesions in coronary segments other than the infarct-related artery. The optimal management of these residual lesions has been extensively studied, with evidence supporting the benefits of complete revascularization. However, controversies exist regarding the timing and strategy of treatment. This review provides a critical appraisal of the available literature, discussing areas of certainty, knowledge gaps, approaches for specific clinical subsets, and future research directions.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Lingyue Zhao, Wenqin Guo, Weichao Huang, Lili Wang, Fanrui Mo, Xiehui Chen, Chaoyang Li, Siquan Huang
Summary: In patients with ST-segment elevation myocardial infarction and multivessel disease, angiography-guided complete revascularization appears to be more effective and associated with lower risk compared to culprit-only revascularization. Additionally, angiography-guided complete revascularization showed lower risk compared to FFR-guided complete revascularization for the primary outcome and myocardial infarction. Further studies directly comparing the effectiveness of these two complete revascularization strategies are warranted to draw more conclusive results.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Medicine, General & Internal
Meng-Jin Hu, Yue-Jin Yang, Jin-Gang Yang
Summary: Based on the results of our meta-analysis, we found that among patients with STEMI and multivessel disease, staged MV-PCI may be the optimal revascularization strategy compared to immediate MV-PCI.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Tobias F. S. Pustjens, Marijke J. C. Timmermans, Saman Rasoul, Arnoud W. J. van't Hof
Summary: The study found that NSTE-ACS patients with MVD undergoing MV-PCI and CO-PCI had similar mortality rates at long-term follow-up, but the MV-PCI group showed improved event-free survival in terms of fewer coronary reinterventions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jiachun Lang, Chen Wang, Le Wang, Jingxia Zhang, Yuecheng Hu, Huajun Sun, Hongliang Cong, Yin Liu
Summary: Staged PCI is superior to culprit-only PCI in elderly patients with STEMI and MVD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Shih-Sheng Chang, Chiung-Ray Lu, Ke-Wei Chen, Zhe-Wei Kuo, Shao-Hua Yu, Shih-Yi Lin, Hong-Mo Shi, Hei-Tung Yip, Chia-Hung Kao
Summary: This study investigated the prognostic differences between elderly patients with ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) by analyzing data from the Longitudinal Health Insurance Database in Taiwan. The results showed that there was no difference in cardiovascular and all-cause mortality between STEMI and NSTEMI in patients who received revascularization. However, in patients who did not receive revascularization, NSTEMI was associated with a higher risk of all-cause death. Moreover, there was no difference in major bleeding between STEMI and NSTEMI patients aged ≥65 years old.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Korakoth Towashiraporn
Summary: ST-segment elevation myocardial infarction is a common and serious disease that requires immediate reperfusion therapy. Multivessel disease is a common complication, which may lead to future cardiovascular events. Percutaneous coronary intervention of the obstructive lesions in non-infarct-related arteries to achieve complete revascularization is the preferred strategy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Kongyong Cui, Dong Yin, Chenggang Zhu, Sheng Yuan, Shaoyu Wu, Lei Feng, Kefei Dou
Summary: This study compared the clinical outcomes of immediate complete revascularization, staged complete revascularization, and culprit-only PCI in hemodynamically stable patients with STEMI and multivessel disease. The results showed that both immediate and staged complete revascularization were associated with a reduction of cardiovascular death or MI compared with culprit-only PCI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Min Chul Kim, Yongwhan Lim, Youngkeun Ahn, Joon Ho Ahn, Seung Hun Lee, Dae Young Hyun, Kyung Hoon Cho, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong
Summary: In this study, the impact of left ventricular remodeling (LVR) on the prognosis of patients with ST-elevated myocardial infarction and multivessel disease was examined. LVR was associated with worse outcomes only in patients who received incomplete revascularization. The study highlights the importance of considering LVR in the management of these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ayman Elbadawi, Mohammed Elzeneini, Islam Y. Elgendy, Michael Megaly, Mohamed Omer, Ernesto Jimenez, Ravi K. Ghanta, Emmanouil S. Brilakis, Hani Jneid
Summary: This study used a nationwide database to analyze the trends and outcomes of isolated coronary artery bypass grafting after ST-elevation myocardial infarction. The results showed a decline in the use of this procedure, but no change in in-hospital mortality. A recent cohort study found that performing the grafting on day 2 had similar in-hospital mortality compared with day 3 or more, but lower rates of complications and shorter hospital stays.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Medicine, General & Internal
Lu-Feng Li, Mei Qiu, Shu-Yan Liu, Hai-Rong Zhou
Summary: Complete revascularization significantly reduces the risk of MACE compared to culprit-only revascularization in STEMI patients with multivessel disease, regardless of sex, age, history of diabetes, ECG infarct location, and the number of arteries with stenosis. The subgroup effects based on the 5 factors of interest were not statistically significant.
Article
Cardiac & Cardiovascular Systems
Simone Biscaglia, Andrea Erriquez, Matteo Serenelli, Fabrizio D'Ascenzo, Gaetano De Ferrari, Albert Ariza Sole, Juan Sanchis, Francesco Giannini, Francesco Gallo, Antonella Scala, Alberto Menozzi, Michele Pighi, Raul Moreno, Gianmarco Iannopollo, Mila Menozzi, Vincenzo Guiducci, Matteo Tebaldi, Gianluca Campo
Summary: The optimal revascularization strategy for older myocardial infarction (MI) patients with multivessel disease (MVD) is currently unknown. This study compared the outcomes of complete revascularization versus culprit-only treatment in older MI patients. The results showed that complete revascularization was associated with lower all-cause and cardiovascular mortality, as well as a lower incidence of myocardial infarction.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Peripheral Vascular Disease
Wen Zheng, Xin Huang, Xuedong Zhao, Wei Gong, Xiao Wang, Shaoping Nie
Summary: This study found that stress hyperglycemia (SHG) is associated with an increased risk of adverse events in non-diabetic patients with ST elevation myocardial infarction (STEMI) and multivessel disease (MVD).
Article
Cardiac & Cardiovascular Systems
Federico Archilletti, Fabrizio Ricci, Francesco Pelliccia, George Dangas, Livio Giuliani, Francesco Radico, Matteo Perfetti, Serena Rossi, Sabina Gallina, Nicola Maddestra, Mohammed Y. Khanji, Marco Zimarino
Summary: This study aimed to identify the best strategy for complete revascularization in patients with multi-vessel disease and ST-elevation myocardial infarction. The results showed that complete revascularization significantly reduced the risk of all-cause death and new myocardial infarction compared to infarct-related artery-only percutaneous coronary intervention. There was no significant difference between angiography-guided and fractional flow reserve-guided complete revascularization in reducing the composite endpoint. Bayesian probability analysis ranked angiography-guided complete revascularization as the best intervention with the lowest risk of the composite endpoint, questioning the role of fractional flow reserve guidance in this setting.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Waqas Ullah, Salman Zahid, Nayab Nadeem, Smitha Gowda, Samavia Munir, Sameer Saleem, M. Chadi Alraies, Mahboob Alam, David L. Fischman
Summary: In patients with STEMI, compared to COR, MVR may be significantly associated with a reduction in major adverse cardiovascular events, angina, and the need for revascularization.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Hao Huang, Yucheng Chen, Zhi Zeng
AMERICAN HEART JOURNAL
(2011)
Article
Medicine, Research & Experimental
Hao Huang, Zhi Zeng, Jing Li, Li Zhang, Yucheng Chen
ARCHIVES OF MEDICAL RESEARCH
(2010)
Article
Cardiac & Cardiovascular Systems
Ling-Ai Pan, Yu-Cheng Chen, Hao Huang, Li Zhang, Rui Liu, Xian Li, Ou Qiang, Zhi Zeng
Article
Medical Laboratory Technology
Yucheng Chen, Hao Huang, Si Liu, Lin-Ai Pan, Bing Zhou, Li Zhang, Zhi Zeng
CLINICAL BIOCHEMISTRY
(2011)
Article
Medical Laboratory Technology
Hao Huang, Zhi Zeng, Li Zhang, Rui Liu, Xian Li, Ou Qiang, Qing Zhang, Yucheng Chen
CLINICAL BIOCHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Yucheng Chen, Li Zhang, Hao Huang, Rui Liu, Xian Li, Ou Qiang, Zhi Zeng
DNA AND CELL BIOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Hao Huang, Zhi Zeng, Li Zhang, Rui Liu, Xian Li, Ou Qiang, Yucheng Chen
MOLECULAR BIOLOGY REPORTS
(2012)
Article
Multidisciplinary Sciences
Ke Wan, Jianxun Zhao, Hao Huang, Qing Zhang, Xi Chen, Zhi Zeng, Li Zhang, Yucheng Chen