Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 69, Issue 8, Pages 934-944Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glt157
Keywords
beta-Cell; Endocrine pancreas; Exocrine pancreas; Pancreatic aging; Pancreatic fibrosis of the elderly
Categories
Funding
- VALi+d program from Generalitat Valenciana [APOSTD/2012/021]
- Instituto de Salud Carlos III-FEDER [PS09/01093]
- Generalitat Valenciana [PROMETEO/2012/007]
- Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion CIBERobn [CB12/03/30038]
- Formacion de Personal Investigador program from the Spanish Ministry of Education
- Formacion de Personal Universitario program from the Spanish Ministry of Education
- Spanish Ministry of Education and Science [AGL2008-01057]
- Autonomous Government of Andalusia [AGR832]
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An adequate pancreatic structure is necessary for optimal organ function. Structural changes are critical in the development of age-related pancreatic disorders. We aimed to study the effect of oil consumption on pancreas histology in order to find aging-related signs. To this end, three groups of rats were fed an isocaloric diet for 2 years, where virgin olive, sunflower, or fish oil was included. Pancreatic samples for microscopy and blood samples were collected at the moment of sacrifice. As a result, the sunflower oil-fed rats presented higher beta-cell numbers and twice the insulin content than virgin olive oil-fed animals. In addition, rats fed with fish oil developed acinar fibrosis and macrophage infiltrates in peri-insular regions, compared with counterparts fed with virgin olive oil. Inflammation signs were less prominent in the sunflower group. The obtained data emphasize the importance of dietary fatty acids in determining pancreatic structure.
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