Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 67, Issue 7, Pages 754-759Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/gls112
Keywords
Aging; Cognition; Inflammation; Oxidative stress; Metabolism
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Funding
- Intramural NIH HHS [ZIA AG000191-15] Funding Source: Medline
- NCATS NIH HHS [UL1 TR000064] Funding Source: Medline
- NIA NIH HHS [P30 AG028740, R01 AG034605, R37 AG036800, R01 AG014979] Funding Source: Medline
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There is increasing evidence from basic science and human epidemiological studies that inflammation, oxidative stress, and metabolic abnormalities are associated with age-related cognitive decline and impairment. This article summarizes selected research on these topics presented at the Cognitive Aging Summit II. Speakers in this session presented evidence highlighting the roles of these processes and pathways on age-related cognitive decline, pointing to possible targets for intervention in nondemented older adults. Specific areas discussed included age differences in the production of cytokines following injury or infection, mechanisms underlying oxidative stress-induced changes in memory consolidation, insulin effects on brain signaling and memory, and the association between metabolic syndrome and cognitive decline in older adults. These presentations emphasize advances in our understanding of mechanisms and modifiers of age-related cognitive decline and provide insights into potential targets to promote cognitive health in older adults.
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