Article
Sport Sciences
Alexander T. Carswell, Sarah Jackson, Paul Swinton, Thomas J. O'Leary, Jonathan C. Y. Tang, Samuel J. Oliver, Craig Sale, Rachel M. Izard, Neil P. Walsh, William D. Fraser, Julie P. Greeves
Summary: This study found that there are associations between serum vitamin D metabolites and physical performance. 25-hydroxyvitamin D (25(OH)D) is negatively correlated with 2.4-km run time and positively correlated with muscle power, while 1,25-dihydroxyvitamin D (1,25(OH)(2)D) is positively correlated with run time and negatively correlated with strength and muscle power. 24,25-dihydroxyvitamin D (24,25(OH)(2)D) is negatively correlated with run time. The vitamin D metabolites together explain a small portion of variance in physical performance. VDR SNPs are not associated with physical performance.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Review
Endocrinology & Metabolism
Fiammetta Romano, Domenico Serpico, Mariateresa Cantelli, Antonella Di Sarno, Carmine Dalia, Rossana Arianna, Mariarosaria Lavorgna, Annamaria Colao, Carolina Di Somma
Summary: Osteoporosis (OP) and Dermatoporosis (DP) are age-related conditions affecting the bones and skin. Both conditions are associated with increased morbidity in elderly individuals, and vitamin D deficiency plays a role in their development. Vitamin D is involved in various mechanisms related to these diseases, including immunomodulation. Deficiency of vitamin D inhibits calcium absorption and optimal bone health, leading to OP. Proper vitamin D is also important in preventing age-related skin issues like DP, as it affects collagen production, epidermal barrier function, inflammation regulation, wound healing, and sun protection.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sinsuda Dechsupa, Wicharn Yingsakmongkol, Worawat Limthongkul, Weerasak Singhatanadgige, Manassanan Jitjumnong, Sittisak Honsawek
Summary: This study aimed to determine serum 25-hydroxyvitamin D (25(OH)D) levels and physical performance, and investigate the association between serum vitamin D levels, muscle strength, and physical activity in elderly patients with LDD. The findings showed that LDD patients with lower serum 25(OH)D levels had prolonged physical performance time. These results suggest that higher serum 25(OH)D levels are associated with better physical performance in LDD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Georgeta Bocheva, Radomir M. Slominski, Andrzej T. Slominski
Summary: The active metabolites of vitamin D-3 and lumisterol have antiaging and photoprotective effects on the skin through immunomodulation, antioxidative responses, and DNA repair mechanisms. They interact with multiple nuclear receptors and have potential for preventing, attenuating, or treating premature skin aging. Further clinical evaluation of topically applied derivatives is needed for future trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Beatrice Arosio, Paolo Dionigi Rossi, Evelyn Ferri, Matteo Cesari, Giovanni Vitale
Summary: Vitamin D levels are significantly associated with cognitive decline, with the lowest levels seen in dementia patients and higher levels in mild cognitive impairment patients.
Article
Nutrition & Dietetics
Denise K. Houston, Anthony P. Marsh, Rebecca H. Neiberg, Jamehl L. Demons, Claudia L. Campos, Stephen B. Kritchevsky, Osvaldo Delbono, Janet A. Tooze
Summary: This study investigated the effect of daily vitamin D supplementation on leg power and physical performance in older adults with low 25(OH)D concentrations. The results showed that 2000 IU/d vitamin D3 did not improve leg power, physical performance, or muscle fiber composition.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Jiaxin Li, Yang Cao, Jie Xu, Jing Li, Chunmei Lv, Qiang Gao, Chi Zhang, Chongfei Jin, Ran Wang, Runsheng Jiao, Hui Zhu
Summary: Vitamin D plays a positive role in learning and memory in aging mice, and it alleviates ferroptosis in aging hippocampal neurons by regulating ferroptosis-related proteins and activating the Nrf2/HO-1 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Etienne Cavalier, Callum G. Fraser, Harjit P. Bhattoa, Annemieke C. Heijboer, Konstantinos Makris, Candice Z. Ulmer, Hubert W. Vesper, Samuel Vasikaran, Pierre Lukas, Pierre Delanaye, Anna Carobene
Summary: The study evaluated the biological variation of 25(OH)D to set analytical performance specifications for measurement uncertainty. The findings showed that participants were not in a steady state, so APS based on measurement uncertainty appear to be more appropriate.
Article
Physiology
Akseli Laaksi, Ilkka Laaksi, Harri Pihlajamaki, Jani P. Vaara, Tiina Luukkaala, Heikki Kyrolainen
Summary: The present study examined the association of serum 25(OH)D levels with physical performance outcomes and serum levels of anabolic hormones in young men. The results showed a positive association between serum 25(OH)D levels and both aerobic and muscular fitness. Participants with sufficient levels of vitamin D also had higher levels of testosterone. Maintaining a sufficient serum 25(OH)D level may have beneficial effects on physical performance and anabolic state in young men.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Emilio Sosa-Diaz, Estefani Yaquelin Hernandez-Cruz, Jose Pedraza-Chaverri
Summary: Vitamin D is considered essential for human health and plays a crucial role in delaying cellular senescence and attenuating oxidative stress, making it a promising candidate for preventing age-related diseases. However, further research is needed to fully understand the mechanisms behind its effects.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Nutrition & Dietetics
Romina P. Martinelli, Sandra Rayego-Mateos, Matilde Alique, Laura Marquez-Exposito, Lucia Tejedor-Santamaria, Alberto Ortiz, Emilio Gonzalez-Parra, Marta Ruiz-Ortega
Summary: With the increase in life expectancy, age-related diseases such as chronic kidney disease are becoming more prevalent, posing a significant health issue in some countries. The lack of biomarkers for early detection of kidney damage and prediction of renal failure progression is a major problem, as current treatments only slow down disease progression. Preclinical research has highlighted the involvement of cellular senescence-related mechanisms in kidney injury and natural aging. In this context, vitamin D or its analogs have shown potential in protecting against kidney injury, with vitamin D deficiency being observed in patients with kidney diseases. This review provides recent evidence on the relationship between vitamin D and kidney diseases, focusing on the underlying mechanisms and the modulation of cellular senescence mechanisms.
Article
Geriatrics & Gerontology
L. J. Strath, L. Meng, A. Rani, P. Sinha, A. J. Johnson, Z. Huo, T. C. Foster, J. D. Edburg, R. B. Fillingim, Y. Cruz-Almeida
Summary: There is a relationship between vitamin D levels and pain intensity and disability, and this relationship is mediated by epigenetics. Improving nutrition status can help promote healthy aging and reduce pain.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Physiology
Anna Ksiazek, Aleksandra Zagrodna, Malgorzata Slowinska-Lisowska, Giovanni Lombardi
Summary: This study aimed to investigate the relationship between vitamin D metabolites and physical performance in athletes. The results showed a significant correlation between vitamin D metabolites and handgrip strength and vertical jump variables. Additionally, free and bioavailable 25-(OH)D were found to be associated with vertical jump parameters.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Gilciane Ceolin, Susana Cararo Confortin, Antonio Augusto Moura da Silva, Cassiano Ricardo Rech, Eleonora d'Orsi, Debora Kurrle Rieger, Julia Dubois Moreira
Summary: This study found that physical activity has a direct effect on serum 25(OH)D, and body fat composition has a small contribution as a mediator in this relationship.
NUTRITION RESEARCH
(2022)
Article
Geriatrics & Gerontology
Nathalia Fidelis Lins Vieira, Carlos Queiroz do Nascimento, Janaina da Silva Nascimento, Sandra Mary Lima Vasconcelos, Joao Araujo Barros-Neto, Ana Celia Oliveira dos Santos
Summary: The study found an association between low serum levels of 25(OH)D, inflammation, and a high risk for cardiovascular diseases in older adults.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Geriatrics & Gerontology
Jaime L. Speiser, Kathryn E. Callahan, Edward H. Ip, Michael E. Miller, Janet A. Tooze, Stephen B. Kritchevsky, Denise K. Houston
Summary: Mobility limitation is common in older adults and can lead to poor health outcomes. This study developed machine learning models using repeated measures data to predict future mobility limitation, with predictors such as ease of getting up from a chair, gait speed, self-reported health status, body mass index, and depression being the most important factors. The models showed good performance in identifying at-risk older adults, highlighting the potential utility of such prediction models in clinical settings for interventions to prevent or delay mobility limitation.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Mark A. Espeland, Jamie Nicole Justice, Judy Bahnson, Joni K. Evans, Medha Munshi, Kathleen M. Hayden, Felicia R. Simpson, Karen C. Johnson, Craig Johnston, Stephen R. Kritchevsky
Summary: Multimorbidity and frailty indices can predict subsequent decline in cognitive and physical function, as well as increased risk of mortality. Accelerated biological aging is captured by these indices. Whether intensive lifestyle interventions targeting these indices can reduce risks for downstream outcomes remains to be seen.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Ka Ki Tse, Rebecca H. Neiberg, Daniel P. Beavers, Stephen B. Kritchevsky, Barbara J. Nicklas, Dalane W. Kitzman, W. Jack Rejeski, Stephen P. Messier, Kristen M. Beavers
Summary: This study examined whether select baseline characteristics influenced the likelihood of an overweight/obese, older adult experiencing a clinically meaningful gait speed response to caloric restriction. The results showed that there was a similar proportion of individuals experiencing a clinically meaningful gait speed change between the caloric restriction and non-caloric restriction groups.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Edward H. Ip, Shyh-Huei Chen, W. Jack Rejeski, Karen Bandeen-Roche, Kathleen M. Hayden, Christina E. Hugenschmidt, June Pierce, Michael E. Miller, Jaime L. Speiser, Stephen B. Kritchevsky, Denise K. Houston, Robert L. Newton, Stephen R. Rapp, Dalane W. Kitzman
Summary: Gait speed and global cognition decline with age, and rates of decline are informative of future functional status. Sex and race moderate the rate of decline, which is important for intervention studies.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Clinical Neurology
Karen Sugden, Avshalom Caspi, Maxwell L. Elliott, Kyle J. Bourassa, Kartik Chamarti, David L. Corcoran, Ahmad R. Hariri, Renate M. Houts, Meeraj Kothari, Stephen Kritchevsky, George A. Kuchel, Jonathan S. Mill, Benjamin S. Williams, Daniel W. Belsky, Terrie E. Moffitt
Summary: This study reveals the association between blood-based DNA methylation algorithms and cognitive impairment and dementia. Different generations of DNA methylation age algorithms have varying degrees of association with cognitive impairment, with the third generation DunedinPACE algorithm showing the strongest correlation in evaluating clinical diagnosis, screening tests, and cognitive tests. A longitudinal analysis in the FHS Offspring Cohort confirms the association between faster pace of aging as measured by DunedinPACE and the risk of developing dementia.
Article
Geriatrics & Gerontology
A. R. M. Saifuddin Ekram, Joanne Ryan, Sara E. Espinoza, Anne B. B. Newman, Anne M. M. Murray, Suzanne G. Orchard, Sharyn M. Fitzgerald, John J. J. McNeil, Michael E. Ernst, Robyn L. Woods
Summary: This study examined the relationship between physical frailty and healthy community-dwelling older adults and explored the impact of frailty on disability-free survival. The results showed that frailty is common among older adults and is associated with factors such as age, waist circumference, education, and ethnicity. Frailty significantly reduces disability-free survival and addressing modifiable correlates such as depression and polypharmacy may help mitigate its adverse effects.
Article
Geriatrics & Gerontology
Kyle D. Moored, Yujia (Susanna) Qiao, Andrea L. Rosso, Frederico G. S. Toledo, Peggy M. Cawthon, Steven R. Cummings, Bret H. Goodpaster, Stephen B. Kritchevsky, Nancy W. Glynn
Summary: Cardiorespiratory fitness and perceived fatigability are associated with life-space mobility in older adults. Higher fitness levels are associated with greater life-space, but the association plateaus at higher fitness levels. Individuals with higher fatigability are more likely to have lower life-space mobility, especially due to physical fatigability.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Anne B. Newman, Sheena Patel, Jorge R. Kizer, Se-Jin Lee, Shalinder Bhasin, Peggy Cawthon, Nathan LeBrasseur, Russel P. Tracy, Peter Ganz, Steven R. Cummings
Summary: Studies using heterochronic parabiosis have found that circulating factors play a role in brain aging in animal models. In this study, the levels of GDF-11, GDF-8, and follistatin were evaluated and their associations with cognitive function, brain MRI findings, and incident dementia were assessed. The results showed that these factors were not significantly correlated with cognitive outcomes or dementia in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Gerontology
Jaime M. Hughes, Rebecca T. Brown, Jason Fanning, Minakshi Raj, Alycia N. S. Bisson, Mira Ghneim, Stephen B. Kritchevsky
Summary: Modifying unhealthy behaviors and/or environments can improve or maintain the health of older adults, but achieving and sustaining behavior change is challenging and involves various domains such as clinical, social, psychological, and political factors. The National Institute on Ageing (NIA) Research Centers Collaborative Network (RCCN) organized a two-day workshop to emphasize the multidisciplinary nature of behavior change in older adults. The workshop focused on the individual, community, and systems-level determinants of behavior change and discussed future research, education, and training opportunities for the six NIA research centers.
Article
Nutrition & Dietetics
Denise K. Houston, Anthony P. Marsh, Rebecca H. Neiberg, Jamehl L. Demons, Claudia L. Campos, Stephen B. Kritchevsky, Osvaldo Delbono, Janet A. Tooze
Summary: This study investigated the effect of daily vitamin D supplementation on leg power and physical performance in older adults with low 25(OH)D concentrations. The results showed that 2000 IU/d vitamin D3 did not improve leg power, physical performance, or muscle fiber composition.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Geriatrics & Gerontology
Atalie C. Thompson, Haiying Chen, Michael E. Miller, Christopher C. Webb, Jeff D. Williamson, Anthony P. Marsh, Christina E. Hugenschmidt, Laura D. Baker, Paul J. Laurienti, Stephen B. Kritchevsky
Summary: This study found that contrast sensitivity is associated with lower extremity physical function in cognitively intact older adults. Lower contrast sensitivity is significantly related to worse performance on physical performance tests, such as gait speed, narrow walking speed, and balance. The relationship between contrast sensitivity and postural sway is influenced by the surface condition, and the effect of contrast sensitivity on gait velocity is greater during fast pace compared to usual pace.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Brendan L. McNeish, Iva Miljkovic, Xiaonan Zhu, Peggy M. Cawthon, Anne B. Newman, Bret Goodpaster, Kristine Yaffe, Caterina Rosano
Summary: This study found a positive association between serum myostatin levels and the amyloid burden in Alzheimer's disease. The association was significant in white men and women, but not in black men or women. Further investigation is needed to understand the role of myostatin in AD pathogenesis and its influence on different racial groups.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Peggy M. Cawthon, Sheena Patel, Anne B. Newman, Shalender Bhasin, Liming Peng, Russell P. Tracy, Jorge R. Kizer, Se-Jin Lee, Luigi Ferrucci, Peter Ganz, Nathan K. LeBrasseur, Steven R. Cummings
Summary: Based on studies from animal models, growth differentiation factor-11 (GDF-11) may have rejuvenating effects in humans. GDF-11 has high sequence homology with GDF-8, and follistatin and follistatin-like protein-3 (FSTL-3) are inhibitory proteins of both GDF-8 and GDF-11. In two prospective cohort studies of older adults, it was found that GDF-8 levels were positively associated with muscle size and strength, while GDF-11 was not significantly associated with strength or performance. This suggests that GDF-8 and its binding proteins may play a role in counteracting age-related loss of muscle mass and strength.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Shivani Sahni, Alyssa B. Dufour, Na Wang, Douglas P. Kiel, Marian T. Hannan, Paul F. Jacques, Emelia J. Benjamin, Ramachandran S. Vasan, Joanne M. Murabito, Anne B. Newman, Roger A. Fielding, Gary F. Mitchell, Naomi M. Hamburg
Summary: This study examined the association between vascular health measures and grip strength and gait speed. The cross-sectional analysis showed a positive association between resting brachial artery diameter and grip strength, as well as between mean arterial pressure (MAP) and grip strength. The longitudinal analysis revealed a significant association between brachial pulse pressure and slower gait speed, but no association with grip strength.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Jamie N. Justice, Xiaoyan Leng, Nathan K. Lebrasseur, Tamara Tchkonia, James L. Kirkland, Natalia Mitin, Yongmei Liu, Stephen B. Kritchevsky, Barbara J. Nicklas, Jingzhong Ding
Summary: Cellular senescence is an aging process exacerbated by obesity and linked to inflammation and chronic diseases. Caloric restriction may improve metabolism by reducing cellular senescence and inflammation. This randomized controlled trial showed that caloric restriction intervention altered specific circulating biomarkers of cellular senescence in middle-aged and older adults with obesity and prediabetes.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)