Article
Urology & Nephrology
Donghai Wen, Linda Zhou, Zihe Zheng, Aditya Surapaneni, Christie M. Ballantyne, Ron C. Hoogeveen, Michael G. Shlipak, Sushrut S. Waikar, Ramachandran S. Vasan, Paul L. Kimmel, Ruth F. Dubin, Rajat Deo, Harold I. Feldman, Peter Ganz, Josef Coresh, Morgan E. Grams, Eugene P. Rhee
Summary: Testican-2, a protein released into circulation by the kidneys, is positively correlated with eGFR and eGFR slope. However, it is unknown whether higher testican-2 levels are associated with lower risk of ESKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Ha-Jin Lim, Seung-Yeob Lee, Hyun-Jung Choi
Summary: The accuracy of ABL90 FLEX PLUS in measuring creatinine and blood urea nitrogen was evaluated, and suitable candidate specimens were identified. The results showed that ABL90 FLEX PLUS had mean differences of -0.10 and -3.51 mg/dL for creatinine and blood urea nitrogen, respectively, compared to other analyzers. Serum was found to be suitable for creatinine testing using ABL90 FLEX PLUS, while citrated whole-blood did not meet the acceptance criteria.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Cynthia Delgado, Neil R. Powe, Glenn M. Chertow, Barbara Grimes, Kirsten L. Johansen
Summary: Among patients receiving dialysis, serum creatinine was higher in Black, Asian, and Hispanic patients than in non-Hispanic White patients. Differences in ICW did not explain the differences in serum creatinine concentration across race groups.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Biophysics
Deepak Kukkar, Monika Chhillar, Ki-Hyun Kim
Summary: A clinical diagnosis of chronic kidney disease (CKD) is commonly achieved by estimating the serum levels of urea and creatinine (CR). Surface-enhanced Raman spectroscopy (SERS) with noble metal nanoparticles (e.g., gold nanoparticles (GNPs)) can greatly amplify SERS signals and achieve ultra-sensitive single molecule-level detection of CKD-specific biomarkers with high specificity and selectivity. This review critically outlines the performance of SERS-based biosensors in the ultrasensitive detection of CKD biomarkers in various body fluids and discusses the challenges and perspectives for their application in practical clinical settings.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Peripheral Vascular Disease
Xianghui Zeng, Qingfeng Zeng, Lanqian Zhou, Hengqing Zhu, Jianping Luo
Summary: The study found that the prevalence of chronic kidney disease, albuminuria, and macroalbuminuria among US adults with hypertension remained relatively stable from 1999 to 2018, but there was an increasing trend in stage 1 CKD.
Review
Urology & Nephrology
Greg Guthrie, Bruce Guthrie, Heather Walker, Matthew T. James, Nicholas M. Selby, Marcello Tonelli, Samira Bell
Summary: This study examined the variation in defining acute kidney injury (AKI) for research using health care data and aimed to achieve consensus. The current methods for defining AKI using routinely collected data are inconsistent and poorly described. Experts could not achieve consensus for many aspects of defining AKI and describing its sequelae. The KDIGO guidelines should be extended to include a standardized definition for AKI when using routinely collected data.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Medical Laboratory Technology
Ulf Nyman, Jonas Bjork, Pierre Delanaye, Alexandre Lahens, Hans Pottel, Emmanuelle Vidal-Petiot, Martin Flamant
Summary: GFR estimating equations can be re-expressed to include rescaled creatinine (sCr/Q) and used across populations with different creatinine generation if population-specific average creatinine concentrations (Q-values) for healthy persons are established.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Geriatrics & Gerontology
Devika Nair, Rasheeda K. Hall
Summary: This article highlights the key findings of three recent studies in nephrology, which are highly relevant to the care of older adults. The studies cover topics such as removing race adjustment in estimating kidney function, using novel therapeutics to halt CKD progression and improve cardiovascular outcomes, and medication management for short-term pain control in CKD patients.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Urology & Nephrology
Jonas Bjork, Ulf Nyman, Anders Larsson, Pierre Delanaye, Hans Pottel
Summary: By establishing sex-specific creatinine growth curves and adjusting creatinine levels in children and young adults below 40 years in the CKD-EPI equation, improvements in bias, precision, and accuracy of estimated GFR were observed across all ages, sexes, and mGFR levels. This strategy makes the CKD-EPI equation applicable across the full spectrum of age and kidney function in children and young adults.
KIDNEY INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Suk Hyung Choe, Hyeyeon Cho, Jinyoung Bae, Sang-Hwan Ji, Hyun-Kyu Yoon, Ho-Jin Lee, Ji-Hyun Lee, Jin-Tae Kim, Won Ho Kim
Summary: The study aimed to evaluate the association between the duration and stage of acute kidney injury (AKI) and the occurrence of chronic kidney disease (CKD) in patients undergoing cardiac or thoracic aortic surgery. Results showed a significant and graded association between AKI stages and the development of new-onset CKD during three years after surgery, with higher duration and severity of AKI providing stronger predictive value for CKD development.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Analytical
Yaping Dong, Xiaojin Luo, Yiqun Liu, Cunling Yan, Haixia Li, Jicheng Lv, Li Yang, Yue Cui
Summary: A disposable creatinine biosensor, based on Prussian blue/carbon-graphite paste and immobilized enzymes, was developed for clinical evaluation of renal function detection. The biosensor showed a linear detection range and high stability, and yielded comparable results to the Jaffe method. This biosensor holds great potential for medical and healthcare applications.
Review
Chemistry, Analytical
Monika Chhillar, Deepak Kukkar, Preeti Kukkar, Ki-Hyun Kim
Summary: Immunoassays have become an important analytical tool for the early-stage diagnosis and treatment monitoring of common diseases like chronic kidney disease (CKD). This review discusses the merits and demerits of various biomarkers for CKD diagnosis and explores different immunoassay types for detecting these biomarkers. It provides valuable insights into the recent advances in nanomaterial-antibody conjugate-based immunoassays for CKD-associated metabolites and biomarkers.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Plant Sciences
Rodrigo Castaneda, Armando Caceres, Sully M. Cruz, J. Agustin Aceituno, E. Sebastian Marroquin, Ana C. Barrios Sosa, Wendy K. Strangman, R. Thomas Williamson
Summary: The prevalence of kidney disease has increased rapidly worldwide, and traditional plants used in Mesoamerican medicine by Mayan groups may provide valuable nephroprotective agents. This study found 208 plant species used for kidney-related problems by 10 Mayan groups, with 42 plants having reported pharmacological activity against kidney damage.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Parasitology
Maria Alfonsa Cavalera, Floriana Gernone, Annamaria Uva, Rossella Donghia, Claudia Zizzadoro, Andrea Zatelli
Summary: This study assessed the efficacy of domperidone plus renal diet in slowing the progression of nephropathy in leishmaniotic dogs with CKD, evaluating sSDMA and sCr as markers of kidney function.
PARASITES & VECTORS
(2022)
Article
Biochemistry & Molecular Biology
Razia Sultana Mohammad, Mustafa F. Lokhandwala, Anees A. Banday
Summary: Age is a risk factor for chronic diseases, including kidney diseases. Oxidative stress and mitochondrial dysfunction play a pathogenic role in aging kidney disease. Activation of the NRF2 signaling pathway can improve kidney and mitochondrial function in aged rats.