Article
Endocrinology & Metabolism
James L. Abelson, Brisa N. Sanchez, Stefanie E. Mayer, Hedieh Briggs, Israel Liberzon, Nirmala Rajaram
Summary: Salivary cortisol stress biomarkers are commonly used in epidemiological research to examine the relationship between stress and health problems. However, there has been limited effort to connect these measures with the biological mechanisms involved in stress-related health outcomes. This study found associations between cortisol diurnal decline and feedback sensitivity, as well as between morning cortisol levels and adrenal sensitivity. It also raised questions about the biological meaning of other curve components, such as morning cortisol levels and the cortisol awakening response.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Cathy Degroote, Roland von Kanel, Livia Thomas, Claudia Zuccarella-Hackl, Nadine Messerli-Burgy, Hugo Saner, Roland Wiest, Petra H. Wirtz
Summary: Research shows that patients with coronary heart disease (CHD) and hypertension have decreased activity in the hypothalamus-pituitary-adrenal (HPA) axis, which may contribute to an increased risk of cardiovascular disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Haimei Xie, Xiaomei Zheng, Ye Huang, Weihao Li, Wenkai Wang, Qiao Li, Jiangtao Hou, Lulu Luo, Xiuying Kuang, Chuan-Quan Lin
Summary: Saliva composition has diurnal variations, which are not affected by citric acid stimulation. The variation characteristics of male and female under resting state and acid stimulation are basically the same, with the trend of salivary alpha-amylase activity being opposite to that of cortisol.
Article
Endocrinology & Metabolism
Yannuo Li, Ioannis P. Androulakis
Summary: The suprachiasmatic nucleus (SCN) synchronizes physiological rhythms and adapts to changes in photoperiod, affecting the phase distribution of neuron activities. Elevated glucocorticoid levels in short photoperiods are associated with peak disease incidence. Topological changes in the SCN network may influence seasonal variations in disease incidence.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Bernhard C. L. Maier, Lea Zillich, Fabian Streit, Katharina Wildenberg, Marcella Rietschel, Hans-Peter Hammes, Stephanie H. Witt, Michael Deuschle
Summary: Adverse childhood experiences (ACEs) have negative effects on health outcomes, and alterations in the hypothalamic pituitary adrenal (HPA) axis might play a role. This study examined the relationship between ACEs and diurnal HPA axis functioning in older adults, and found that type and timing of ACEs influence HPA axis activity in old age.
PSYCHONEUROENDOCRINOLOGY
(2022)
Review
Biology
Isabella Robertson-Dixon, Melanie J. Murphy, Sheila G. Crewther, Nina Riddell
Summary: This systematic review evaluated the effects of daytime exposure to lights of different spectral wavelength characteristics and luminance intensity on cortisol levels in healthy individuals. The analysis indicated that exposure to bright lights of any color during the late night or early morning can significantly increase cortisol secretion, and exposure to bright lights with stronger short-wavelength (blue/green) components in the early morning typically induces greater increases in cortisol. Therefore, the circadian regulation of cortisol is sensitive to the wavelength composition of environmental lighting.
Article
Psychology, Developmental
Christina Y. Cantave, Mara Brendgen, Sonia Lupien, Ginette Dionne, Frank Vitaro, Michel Boivin, Isabelle Ouellet-Morin
Summary: This study found that early socioeconomic adversity sensitizes the HPA axis to later socioeconomic disadvantage, which may have consequences for socioemotional and behavioral functioning. Social support was found to moderate this association.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Kristen Nishimi, Karestan C. Koenen, Brent A. Coull, Suzanne C. Segerstrom, S. Bryn Austin, Laura D. Kubzansky
Summary: Psychological resilience is associated with diurnal salivary cortisol levels in young adults. A high burden of early adversity may disrupt the physiological stress system, while psychological health may be associated with more normative cortisol levels when adversity is low.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Jelena Bakusic, Manosij Ghosh, Andrea Polli, Bram Bekaert, Wilmar Schaufeli, Stephan Claes, Lode Godderis
Summary: The study revealed that job stress was associated with increased levels of cortisol and cortisone in burnout participants. Changes in DNA methylation of the NR3C1 and SLC6A4 genes were observed in burnout individuals, and some of these methylation changes correlated with burnout symptoms. Increased methylation in a specific CpG in the SLC6A4 gene moderated the association between job stress and burnout, while DNA methylation in this CpG was also associated with increased cortisol levels. Furthermore, average methylation of NR3C1 was negatively associated with cortisone levels.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Endocrinology & Metabolism
Anne Berens, Joelle LeMoult, Katharina Kircanski, Ian H. Gotlib
Summary: This study examined the association between symptoms of attention deficit-hyperactivity disorder (ADHD) and diurnal cortisol output. It found that ADHD symptoms were significantly associated with higher cumulative diurnal cortisol, morning cortisol, and afternoon cortisol. However, symptoms of comorbid psychiatric disorders such as conduct disorder, anxiety, and depression did not show significant associations with cortisol levels.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Man Li, Qili Lan, Lirong Qiu, Yidan Yuan, Fengjiao He, Chen Zhang, Linlin Zhang
Summary: This study examined the HPA axis functioning in left-behind adolescents in China and its mediating role in the association between family emotional expressiveness and internalizing problems. The results found a negative association between negative family expressiveness and diurnal cortisol, as well as a negative association between diurnal cortisol and internalizing problems. Further analysis showed that diurnal cortisol secretion mediated the association between negative family expressiveness and internalizing problems.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Lindsay Till Hoyt, Katharine H. Zeiders, Natasha Chaku, Li Niu, Stephanie H. Cook
Summary: Previous research has primarily focused on specific indicators of diurnal HPA axis functioning, with little consideration of the interactions between these indicators. This study introduces a novel approach using latent profile analysis to generate diurnal cortisol profiles based on five indicators, finding that a specific combination of cortisol parameters may predict mental health risk.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Pauline S. Effenberger, Tabea S. Send, Maria Gilles, Josef Frank, Stephan Bongard, Robert Kumsta, Stephanie H. Witt, Marcella Rietschel, Michael Deuschle, Fabian Streit, Isabell A. C. Wolf
Summary: There is no strong association between urbanicity and behavior problems or HPA axis regulation in preschool age, and urinary cortisol and salivary cortisol response after stress exposure are not identified as mediators of this relationship.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Elena Gonzalez Rodriguez, Pedro Marques-Vidal, Berengere Aubry-Rozier, Georgios Papadakis, Martin Preisig, Christine Kuehner, Peter Vollenweider, Gerard Waeber, Didier Hans, Olivier Lamy
Summary: This study explored the relationship between diurnal salivary cortisol values and sarcopenia diagnosis in postmenopausal women. The findings showed that sarcopenic women had higher salivary cortisol levels at 11 AM and 8 PM. Additionally, salivary cortisol levels were inversely correlated with grip strength.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Psychiatry
Sonja Entringer, Laura Scholaske, Medlin Kurt, Elif Aysimi Duman, Emma K. Adam, Oliver Razum, Jacob Spallek
Summary: Immigrants from Turkey in Germany experience health disadvantages, possibly due to chronic stress and dysregulation of physiological systems. A study found that pregnant women of Turkish origin had different diurnal cortisol variation compared to non-migrant women, which may impact the health of their offspring.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)