Article
Biochemistry & Molecular Biology
Masuelli Sofia, Real Sebastian, Campoy Emanuel, Maria Teresita Branham, Diego Matias Marzese, Salomon Matthew, Gerardo De Blas, Arias Rodolfo, Levin Michael, Roque Maria
Summary: This study discovered differential DNA methylation and bioelectric differences between left-sided and right-sided breast tumors, which were associated with tumor proliferation. These findings provide new targets for future breast cancer therapeutic approaches.
MOLECULAR MEDICINE
(2022)
Article
Neurosciences
Leah T. Johnstone, Emma M. Karlsson, David P. Carey
Summary: Neuroscientific techniques show that left-handers have more unusual cerebral asymmetries for language compared to right-handers, with left-handers demonstrating less lateralization for language, faces, and bodies when they have typical cerebral asymmetries.
Article
Biochemistry & Molecular Biology
Jianguo Wang, Sidi Ma, Peijie Yu, Xionglei He
Summary: The human brain exhibits anatomical symmetry, but also possesses fine-scale structural asymmetries that contribute to distinct functional divisions. Previous studies suggested that these asymmetric structures are primate specific or unique to humans, indicating recent evolution of genes responsible for human brain asymmetry. In our study, we identified over 1,500 traits associated with human brain asymmetry and discovered approximately 200 genes that are predominantly upregulated in brain tissues. Surprisingly, these genes are evolutionarily ancient and show brain-specific upregulation in humans, indicating the role of ancient genes in shaping the structural asymmetry of the human brain over time.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Article
Multidisciplinary Sciences
Xin-Xin Fu, Ding-Hao Zhuo, Ying-Jie Zhang, Yun-Fei Li, Xiang Liu, Yan-Yi Xing, Ying Huang, Yi-Fan Wang, Tao Cheng, Dan Wang, Si-Han Chen, Yi-Jian Chen, Guan-Nan Jiang, Fu- Lu, Yu Feng, Xiao Huang, Jun Ma, Wei Liu, Ge Bai, Peng-Fei Xu
Summary: The emergence of left-right (LR) asymmetry in a patterning field along the anterior-posterior axis is still an unresolved problem in developmental biology. This study identifies Follistatin (Fst) as a regulator that restricts the propagation of Nodal ortholog Southpaw (Spaw) in the right lateral plate mesoderm (LPM) and facilitates the establishment of a robust LR asymmetric Nodal patterning. Furthermore, Fst inhibits the Activin-Nodal signaling pathway in the forebrain, contributing to the orderly propagation of asymmetric Nodal activation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Psychology, Biological
Zhiqiang Sha, Dick Schijven, Amaia Carrion-Castillo, Marc Joliot, Bernard Mazoyer, Simon E. Fisher, Fabrice Crivello, Clyde Francks
Summary: Genes associated with brain asymmetry are linked to microtubule-related genes and embryonic brain expression, and have overlap with genetic variants related to autism, educational attainment, and schizophrenia. Left-right hemispheric asymmetry is crucial for healthy brain organization and language functions, but the mechanism behind establishing the human brain's left-right axis remains unidentified.
NATURE HUMAN BEHAVIOUR
(2021)
Article
Developmental Biology
Brent H. Wyatt, Nirav M. Amin, Kristen Bagley, Dustin Wcisel, Michael K. Dush, Jeffrey A. Yoder, Nanette M. Nascone-Yoder
Summary: This study reveals the role of single-minded 2 gene in regulating left-right symmetry in the development of frog embryo stomach, further illustrating the importance of laterality factors in morphogenesis.
Article
Cell Biology
Eriko Kajikawa, Toru Miki, Masayoshi Takeda, Hiroshi Kiyonari, Hiroshi Hamada
Summary: The evolutionary diversity of brain left-right asymmetry was examined by studying reptile embryos. The Chinese softshell turtle and the red-eared slider turtle showed left-sided expression of certain genes in the developing forebrain, while this asymmetry was not detected in the Madagascar ground gecko. These findings suggest that brain left-right asymmetry varies even among reptiles.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Teije C. Middelkoop, Julia Garcia-Baucells, Porfirio Quintero-Cadena, Lokesh G. Pimpale, Shahrzad Yazdi, Paul W. Sternberg, Peter Gross, Stephan W. Grill
Summary: This study demonstrates that the active torque generation dependent on CYK-1/Formin plays a crucial role in chiral symmetry breaking of actomyosin flows, driving left-right symmetry breaking in the nematode worm. The activity of Non-Muscle Myosin II, on the other hand, promotes cortical actomyosin flows but is not essential for chiral symmetry breaking.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Naiara Demnitz, Kathrine Skak Madsen, Line K. Johnsen, Michael Kjaer, Carl-Johan Boraxbekk, Hartwig R. Siebner
Summary: The study found that older adults show similar trends of asymmetry in the white matter microstructure of the corticospinal tract and dexterity as adolescents, but to a lesser degree. However, unlike adolescents, there was no evidence of a linear relationship between CST microstructure asymmetry and dexterity in older adults.
Article
Management
Laszlo Csato
Summary: This paper compares the performance of the eigenvalue method and the row geometric mean as two weighting procedures. Through numerical experiments, it is found that the priorities derived from the two eigenvectors in the eigenvalue method do not always agree, while the row geometric mean serves as a compromise between them.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2024)
Article
Neurosciences
Helena Verhelst, Thijs Dhollander, Robin Gerrits, Guy Vingerhoets
Summary: Language is predominantly lateralised to the left hemisphere in over 90% of the population. Research using fixel-based analysis found a consistent pattern of white matter lateralisation, with the arcuate fasciculus showing leftward lateralisation regardless of functional language dominance. In addition, a significant group difference in lateralisation was observed in the forceps minor, with leftward lateralisation in the LLD group and rightward lateralisation in the RLD group.
Article
Surgery
David K. Chong, Mithila Somasundaram, Emily Ho, Nicolas S. Dhooghe, David M. Fisher
Summary: Left and right complete cleft lips have anthropometric differences, with right cleft lips showing greater deficiencies in lateral lip element development.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Genetics & Heredity
Yang Zhang, Fan Mao, Shu Xiao, Haiyan Yu, Zhiming Xiang, Fei Xu, Jun Li, Lili Wang, Yuanyan Xiong, Mengqiu Chen, Yongbo Bao, Yuewen Deng, Quan Huo, Lvping Zhang, Wenguang Liu, Xuming Li, Haitao Ma, Yuehuan Zhang, Xiyu Mu, Min Liu, Hongkun Zheng, Nai-Kei Wong, Ziniu Yu
Summary: By sequencing the genome of C. hongkongensis and comparing it to other reference bivalve genomes, this study identified the genomic determinants driving the shift from byssal to cemented attachment in oysters. The loss of the Antennapedia gene and expansion of lineage-specific extracellular gene families were found to be implicated in this transition. Transcriptomic analysis revealed significant differences in gene expression profiles between the asymmetrical C. hongkongensis and the symmetrical P. fucata, including elevated expression of orthologous transcription factor genes and lineage-specific shell-related gene families.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2022)
Article
Chemistry, Multidisciplinary
Mirae Ok, Ka Young Kim, Heekyoung Choi, Seonghan Kim, Shim Sung Lee, Jaeheung Cho, Sung Ho Jung, Jong Hwa Jung
Summary: The study explores chiral self-sorting in supramolecular polymerization and uncovers the ability of Ag+ to induce the formation of aggregates with different chirality from one enantiomeric component. The results demonstrate that helicity and shape discrimination can drive chiral self-sorting. Furthermore, the study reveals the existence of metastable products and the rearrangement of aggregates I and III contributing to homochiral self-sorting. This research is significant for understanding homochirality in complex biological models and for the development of new chiral materials and catalysts.
Article
Cell Biology
Maria Isabella Negretti, Nina Boese, Natalia Petri, Stanislav Kremnyov, Nikoloz Tsikolia
Summary: The development of visceral left-right asymmetry in bilateria relies on initial symmetry breaking and subsequent molecular patterning. The expression of the transcription factor pitx2 on the left side is facilitated by the asymmetric expression of the nodal morphogen in the left lateral plate mesoderm. The mechanisms leading to the asymmetric nodal domain differ depending on the mode of symmetry breaking.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)