Review
Veterinary Sciences
Lola Llobat
Summary: Regulation of pluripotency, cellular differentiation, and growth factors in early mammalian embryonic development varies among different species, with some genes and growth factors playing essential roles in certain species but not in others. The mechanisms controlling cellular differentiation may not be clear or evolutionarily conserved. Growth factors not only affect cell growth but also influence genes related to pluripotency in the earliest stages of development, with effects differing among species.
VETERINARY SCIENCES
(2021)
Article
Engineering, Marine
Poul S. Larsen, Hans Ulrik Riisgard
Summary: This study develops a model to determine the pumping rate of sponges based on factors such as size and geometric length scales, demonstrating that the relationship between pumping rate and size is primarily influenced by hydraulics and pressure losses of the aquiferous system.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2021)
Article
Biodiversity Conservation
Louise S. Norgaard, Mariana Alvarez-Noriega, Elizabeth McGraw, Craig R. White, Dustin J. Marshall
Summary: The distribution and abundance of disease vectors like mosquitoes are changing due to factors such as climate change, invasions, and vector control strategies. Most models currently ignore the nonlinear relationship between wing length and reproduction in mosquitoes, leading to potential biases in population growth estimates. Incorporating hyperallometric relationships in future disease vector models is crucial for accurately predicting changes in mosquito distribution.
GLOBAL CHANGE BIOLOGY
(2022)
Article
Cell Biology
Mengting Shen, Shengli Li, Yiming Zhao, Yizhe Liu, Zhen Liu, Lin Huan, Yejun Qiao, Lu Wang, Leng Han, Zhiao Chen, Xianghuo He
Summary: Liver cancer stemness is closely related to tumour malignancy, and this study identifies the transcription factor ARID3A as a key regulator of stemness in liver cancer. ARID3A interacts with CEP131 and activates KDM3A, leading to the upregulation of downstream genes associated with embryonic stem cell signature and promoting liver cancer metastasis. The ARID3A/CEP131-KDM3A regulatory circuit may serve as a prognostic indicator and potential therapeutic target for liver cancer.
CELL DEATH & DISEASE
(2022)
Article
Nanoscience & Nanotechnology
Xunzhu Zhou, Qiu Zhang, Zhimeng Hao, Yilin Ma, Oleg A. Drozhzhin, Fujun Li
Summary: The study reveals that Zn nuclei grow horizontally in radial direction during initial nucleation and early stages, and they dissolve reversibly in a top-down process. The critical nucleation radius and density are dependent on the electrolyte concentration of ZnCl2, providing guidelines for regulating uniform metal electrodeposition and yielding benefits for the development of anode-free batteries.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Endocrinology & Metabolism
Jennifer Harrington, Mark R. Palmert
Summary: This article discusses the evaluation and treatment of youth with delayed puberty by pediatric endocrinologists, as well as the challenges and approaches in different scenarios.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Ecology
Giuseppe Fusco, Alessandro Minelli
Summary: The article examines the post-embryonic segment addition in arthropods and emphasizes the evolution across hatching. It discusses the developmental changes underlying arthropod segmentation evolution with critical application of key concepts, showing the complexity of processes occurring across hatching.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2021)
Article
Multidisciplinary Sciences
Gregory Reeves, Anoop Tripathi, Pallavi Singh, Maximillian R. W. Jones, Amrit K. Nanda, Constance Musseau, Melanie Craze, Sarah Bowden, Joseph F. Walker, Alison R. Bentley, Charles W. Melnyk, Julian M. Hibberd
Summary: The study demonstrates that in three groups of monocotyledons, grafting can occur using the embryonic hypocotyl. This overturns the belief that monocotyledons are incapable of forming graft unions, and identifies the hypocotyl as a meristematic tissue that allows this process.
Article
Biology
Jeffrey Carbillet, Benjamin Rey, Rupert Palme, Chloe Monestier, Luca Borger, Typhaine Lavabre, Marie-Line Maublanc, Nicolas Cebe, Jean-Luc Rames, Guillaume Le Loc'h, Marine Wasniewski, Benoit Rannou, Emmanuelle Gilot-Fromont, Helene Verheyden
Summary: The study found that long-term elevation of glucocorticoids may impair immune functions. However, the relationship between stress and immunity in wild animals is less clear. This study re-explored the stress-immunity relationship, considering the potential effects of behavioral profiles. The results showed that individuals with increased glucocorticoid levels exhibited increased immunity and were characterized by more reactive behavioral profiles. These findings highlight the need to consider the interplay between behavior, immunity, and glucocorticoids when studying the stress-immunity relationships in wildlife.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ben Mulcahy, Daniel K. Witvliet, James Mitchell, Richard Schalek, Daniel R. Berger, Yuelong Wu, Doug Holmyard, Yangning Lu, Tosif Ahamed, Aravinthan D. T. Samuel, Andrew D. Chisholm, Jeff W. Lichtman, Mei Zhen
Summary: During development, the motor circuit of C. elegans undergoes structural remodeling while maintaining functional output. This remodeling occurs through transient interactions between embryonic and post-embryonic motor neurons, synapse development between post-embryonic neurons and their future partners, sequential building of structural machinery, and region-by-region transition from asymmetric to symmetric wiring.
Review
Immunology
Elisabeth J. M. Huijbers, Kabir A. Khan, Robert S. Kerbel, Arjan W. Griffioen
Summary: Tumors can escape immunity by inducing a state of unresponsiveness in tumor vasculature, leading to compromised immune responses. By mimicking embryonic mechanisms through angiogenesis, tumors enforce immune privileged conditions to ensure uninterrupted growth.
SCIENCE IMMUNOLOGY
(2022)
Article
Economics
Vahid Akbari, Davood Shiri, F. Sibel Salman
Summary: This article studies post-disaster road restoration problem, analyzing the performance of online algorithms against offline optimal solutions using competitive ratio. An optimal online algorithm is proposed, utilizing mixed integer programming model and a novel polynomial time online algorithm, showing superior performance in experiments.
TRANSPORTATION RESEARCH PART B-METHODOLOGICAL
(2021)
Article
Multidisciplinary Sciences
Cora Chalar, Graciela Clivio, Jimena Montagne, Alicia Costabile, Analia Lima, Nicolas G. Papa, Nibia Berois, Maria Jose Arezo
Summary: The study used a shotgun proteomics approach to investigate embryonic diapauses in annual killifish, revealing changes in proteins related to metabolic pathways, DNA repair, and stress tolerance, as well as a switch in cytoskeletal proteins. These findings expand our understanding of diapause regulation at the molecular level and provide insights for future comparative studies among different diapauses in annual killifish and other organisms.
Article
Cell Biology
Cuifang Zhang, Tianqi Li, Shuyao Yin, Mingyi Gao, Helen He, Ying Li, Dong Jiang, Minghui Shi, Jianbin Wang, Li Yu
Summary: This study finds that monocytes in chicken embryos foster a pro-angiogenic microenvironment by depositing migrasomes enriched in angiogenic factors before angiogenesis.
NATURE CELL BIOLOGY
(2022)
Article
Biochemical Research Methods
Daniel Capek, Matvey Safroshkin, Hernan Morales-Navarrete, Nikan Toulany, Grigory Arutyunov, Anica Kurzbach, Johanna Bihler, Julia Hagauer, Sebastian Kick, Felicity Jones, Ben Jordan, Patrick Mueller
Summary: This study uses machine learning to develop a deep convolutional neural network, EmbryoNet, for automated phenotyping of zebrafish signaling mutants. This network accurately identifies and classifies phenotypic defects caused by loss of function in major signaling pathways relevant for vertebrate development. The classification algorithms have wide applications in developmental biology and can identify signaling defects in evolutionarily distant species. Additionally, EmbryoNet can be used for mechanism of action determination in high-throughput drug screens.
