Journal
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
Volume 15, Issue 5, Pages 429-437Publisher
ZHEJIANG UNIV
DOI: 10.1631/jzus.B1400076
Keywords
mRNA; Alternative polyadenylation (APA); Polyadenylation site (PAS)
Categories
Funding
- National Institutes of Health (NIH), USA [R01 GM090056]
Ask authors/readers for more resources
The majority of eukaryotic genes produce multiple mRNA isoforms with distinct 3' ends through a process called mRNA alternative polyadenylation (APA). Recent studies have demonstrated that APA is dynamically regulated during development and in response to environmental stimuli. A number of mechanisms have been described for APA regulation. In this review, we attempt to integrate all the known mechanisms into a unified model. This model not only explains most of previous results, but also provides testable predictions that will improve our understanding of the mechanistic details of APA regulation. Finally, we briefly discuss the known and putative functions of APA regulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available