Journal
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
Volume 11, Issue 6, Pages 417-422Publisher
ZHEJIANG UNIV
DOI: 10.1631/jzus.B0910731
Keywords
Gold nanorods; Polyelectrolyte; Scattering; Raman; Cancer cell imaging
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Funding
- Swedish Foundation for Strategic Research (SSF)
- US Air Force Office of Scientific Research (Asia Office)
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We report the application of multilayered polyelectrolyte-coated gold nanorods (GNRs) as multifunctional optical contrast agents for cancer cell imaging. The surface modification of GNRs improves their chemical stability and facilitates them to be taken up by cancer cells through electrostatic interaction. The unique longitudinal surface plasmon resonance property of GNRs makes them suitable as both scattering contrast agents and Raman contrast agents. In our experiments, the staining of GNRs in cells was further confirmed by dark field microscopy and Raman microscopy. Our experiment results indicated that GNRs have great potential as multifunctional optical contrast agents for future in vivo animal imaging.
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