Journal
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
Volume 25, Issue 6, Pages 969-974Publisher
JOURNAL WUHAN UNIV TECHNOLOGY
DOI: 10.1007/s11595-010-0131-y
Keywords
zwitterionic; phosphobetaine; silk fibroin; blood compatibility; platelet adhesion
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Funding
- National High Technology Research and Development Program(863) of China [2006AA03Z445]
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Zwitterionic phosphobetaine bearing a hydroxyl and a zwitterionic group, 8-hydroxy-2-octyl phosphorylcholine (HOPC), was synthesized and constructed to the surface of silk fibroin(SF) films in order to improve the hemocompatibility of fibroin films by a an isocyanate head group. The surface characteristics of the modified films were measured by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and electron spectroscopy for chemical analysis (ESCA), displaying the successful immobilization of Zwitterionic phosphobetaine on the surface of these fibroin films. Moreover, the further platelet adhesion test in platelets rich plasma (PRP) of human beings showed the zwitterionic phosphobetaine led mainly to good nonthrombogenicity. The experimental results indicated a reasonable approach to improve the blood compatibility of fibroin films.
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