Article
Rheumatology
Daniela M. R. Lourenco, Daniel B. Araujo, Nadia E. Aikawa, Lucas Y. S. Yamakami, Eduardo F. Borba, Gustavo A. R. Maciel, Jose M. Soares-Junior, Edmund C. Baracat, Rosa M. R. Pereira, Eloisa Bonfa, Clovis A. Silva
Summary: The study assessed the adrenal hormones in childhood-onset systemic lupus erythematosus (cSLE) patients and the impact of prednisone on hormones and ovarian reserve. It was found that cSLE patients had overall adrenal suppression, with prednisone potentially contributing to these abnormalities and affecting ovarian reserve independently of immunosuppressants.
CLINICAL RHEUMATOLOGY
(2021)
Article
Obstetrics & Gynecology
Ehab F. Girbash, Shaimaa M. Abdelwahab, Dalia S. Fahmi, Hussein M. Abdeldayem, Rania Ghonaim, Doaa S. Atta
Summary: This study investigates the impact of SLE on the fertility of young women of reproductive age. The results show that SLE patients have decreased levels of AMH, OV, and AFC, which are correlated with age, activity, and damage levels of SLE. CD4(+) T cells and natural killer cells are significantly reduced in SLE patients as well.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Hematology
Leda Coelewij, Kirsty E. Waddington, George A. Robinson, Elvira Chocano, Thomas McDonnell, Filipa Farinha, Junjie Peng, Pierre Donnes, Edward Smith, Sara Croca, Jyoti Bakshi, Maura Griffin, Andrew Nicolaides, Anisur Rahman, Elizabeth C. Jury, Ines Pineda-Torra
Summary: This study found that patients with SLE have global changes in their lipoprotein profiles, but standard serum lipid measurements cannot accurately predict their risk of cardiovascular disease. Serum metabolites may be promising biomarkers to uncover the multi-metabolic phenotypes of subclinical atherosclerosis in SLE patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Immunology
Like Zhao, Xianda Hu, Fei Xiao, Xuan Zhang, Lidan Zhao, Min Wang
Summary: Nucleic acid autoantibodies, increased levels of interferon, and hyperactivation of immune cells are important factors in the development of systemic lupus erythematosus (SLE). Mitochondrial reactive oxygen species (mROS), produced during cellular energy generation, play a crucial role in regulating cell activation and differentiation, as well as the antigenicity of oxidized nucleoids within mitochondria. Recent research has focused on using mROS scavengers and restoring defective mitophagy to address mitochondrial redox imbalance in SLE. However, the underlying mechanisms of how oxidative stress-related mitochondrial molecules influence cell fate at the molecular level are still unknown.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Wei He, Jie Li, Pengyuan Zhang, Minjie Wan, Peihan Xie, Liuqin Liang, Donghong Liu
Summary: This study evaluated global myocardial work (MW) in systemic lupus erythematosus (SLE) patients with normal left ventricular ejection fraction (LVEF) using two-dimensional speckle-tracking imaging (2D-STI). The results showed that SLE patients had higher global wasted work (GWW) and lower global work efficiency (GWE) compared to healthy controls, indicating the potential use of these parameters for the early detection of subclinical left ventricular dysfunction.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Sara C. Croca, Maura Griffin, Filipa Farinha, David A. Isenberg, Andrew Nicolaides, Anisur Rahman
Summary: Patients with SLE have an increased risk of developing cardiovascular disease, with studies showing increased carotid plaques and greater IMT compared to healthy controls. TPA and plaque echogenicity may be more relevant to cardiovascular risk. Longitudinal studies are needed to determine the value of these measures in managing cardiovascular risk in SLE.
Article
Medicine, Research & Experimental
Yi Zhang, Lingzhen Hu, Xiang Li, Liheng Chen, Xuyan Yang
Summary: Patients with active SLE had higher levels of serum Slit2, especially those with chronic kidney disease (CKD), indicating a potential correlation between serum Slit2 levels and disease activity in SLE. Moreover, renal expression of Slit2 and its receptor Robo1 were elevated in patients with lupus nephritis.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Valeria Rella, Cinzia Rotondo, Alberto Altomare, Francesco Paolo Cantatore, Addolorata Corrado
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical manifestations. Dysregulation of the immune system due to genetic, hormonal, and environmental factors can lead to various complications, including bone involvement such as osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Shunxiang Li, Huihua Ding, Ziheng Qi, Jing Yang, Jingyi Huang, Lin Huang, Mengji Zhang, Yuanjia Tang, Nan Shen, Kun Qian, Qiang Guo, Jingjing Wan
Summary: Serum metabolic fingerprints can be used for disease diagnosis and biomarker discovery. By analyzing the serum metabolic fingerprints of systemic lupus erythematosus (SLE) patients and healthy controls, early diagnosis and precision medicine for SLE can be achieved. This study identified the unique metabolic pattern of SLE patients and screened out a panel of metabolic biomarkers.
Article
Dentistry, Oral Surgery & Medicine
Monica Zamora-Pasadas, Rafael Marfil-Alvarez, Pablo Gonzalez-Bustos, Antonio Magan-Fernandez, Francisco Mesa
Summary: The prevalence of periodontitis is higher in patients with systemic lupus erythematosus (SLE) and those with periodontitis have a higher risk of subclinical atherosclerosis. Patients with higher gingival bleeding are also at a higher risk of SLE.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hui-Ching Hsu, Yu-Hsuan Chen, Tin-Syuan Lin, Chieh-Yu Shen, Song-Chou Hsieh
Summary: Systemic lupus erythematosus (SLE) is associated with dysregulated interleukin (IL)-6 and autophagy, with increased IL-6 and impaired autophagy observed in SLE patient macrophages. In vitro studies showed that exogenous IL-6 induced autophagic impairment in macrophages, which could be reversed by tocilizumab treatment. This suggests that IL-6 affects autophagic degradation in SLE macrophages through IL-6R augmentation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Medicine, General & Internal
Johan Frostegard
Summary: The prognosis in systemic lupus erythematosus (SLE) has improved, but cardiovascular disease (CVD) still remains a significant clinical problem. Atherosclerosis and antiphospholipid antibody syndrome are the main underlying causes of CVD in SLE. Inflammation and low levels of anti-phosphorylcholine also contribute to the increased risk of CVD in SLE. Close monitoring and treatment of both traditional and non-traditional risk factors are important.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cell Biology
Jaqueline Cristina de Amorim, Samara Rosa Sepresse, Jessica Fernandes Vivaldo, Paulo Rogerio Julio, Simone Thiemi Kishimoto, Roberto Marini, Paula Teixeira Fernandes, Lilian T. L. Costallat, Simone Appenzeller
Summary: This study aimed to evaluate the cognitive performance of SLE patients and examine the differences compared to healthy controls. It also investigated the relationship between cognitive function and factors such as disease onset, disease activity, and disease damage. The results showed that SLE patients had a higher prevalence of cognitive dysfunction, particularly in memory and attention, and disease activity was associated with worse cognitive function.
