Article
Cardiac & Cardiovascular Systems
Guan Wang, Yanbo Zhang, Sijin Li, Jun Zhang, Dongkui Jiang, Xiuzhen Li, Yulin Li, Jie Du
Summary: This study developed a model based on machine learning to predict postpartum cardiovascular risk in preeclamptic women. The Random Forest algorithm showed the best performance in predicting cardiovascular risk, with good calibration and high net benefit.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Seung-Woo Yang, Min-Jeong Oh, Keon-Vin Park, Sung-Won Han, Hee-Sun Kim, In-Sook Sohn, Han-Sung Kwon, Geum-Joon Cho, Han-Sung Hwang
Summary: The study found that preeclampsia can affect the body mass index and the incidence of obesity in offspring, even in cases where offspring were born with low birth weight. This may help explain the occurrence of various cardiovascular and metabolic complications in offspring affected by preeclampsia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Kaspar Ratnik, Kristiina Rull, Oliver Aasmets, Triin Kikas, Ele Hanson, Kalle Kisand, Krista Fischer, Maris Laan
Summary: Preeclampsia is a common pregnancy-related disease that has negative impacts on the health of both mothers and infants. A study has shown that a multiplex assay called 6PLEX can be used to develop prediction models for early pregnancy to detect preeclampsia. This model combines the measurement of multiple maternal serum biomarkers and other parameters, resulting in high accuracy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Peripheral Vascular Disease
Chao-yan Yue, Jiang-ping Gao, Chun-yi Zhang, Ying-hua Ni, Chun-mei Ying
Summary: A new nomogram was developed and validated for early prediction of preeclampsia in pregnant Chinese women before diagnosis. The model included BMI, blood pressure, uterine artery ultrasound parameters, and serological indicator risk factors, showing good discrimination and calibration. This nomogram can facilitate the individualized prediction of preeclampsia.
HYPERTENSION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Maria G. Hauge, Peter Damm, Klaus F. Kofoed, Anne S. Ersboll, Marianne Johansen, Per E. Sigvardsen, Mathias B. Moller, Andreas Fuchs, Jorgen T. Kuhl, Borge G. Nordestgaard, Lars Kober, Finn Gustafsson, Jesper J. Linde
Summary: This study found that younger women with previous preeclampsia had a slightly higher prevalence of coronary atherosclerosis compared to women from the general population. Preeclampsia remained an independent risk factor for coronary atherosclerosis after adjusting for traditional cardiovascular risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yonggang Zhang, Yipeng Zhang, Limin Zhao, Junzhu Shi, Hongling Yang, Maurizio Mandala
Summary: This study aimed to predict preeclampsia by combining plasma protein SerpinA5 with uterine artery Doppler ultrasound and clinical risk factors during the first trimester. Results showed that SerpinA5 levels were elevated in preeclampsia placental tissue and plasma, potentially interfering with trophoblastic cell invasion. When combined with UtA-PI, pre-pregnancy BMI, and family history of PE, plasma SerpinA5 could effectively predict preeclampsia.
Article
Biology
Yuting Xue, Nan Yang, Xunke Gu, Yongqing Wang, Hua Zhang, Keke Jia
Summary: An early-onset preeclampsia prediction model was established by investigating the clinical characteristics, risk factors, and routine laboratory indicators of pregnant women in early gestational weeks. The combination of PE risk factors and routine laboratory indicators significantly improved the prediction efficacy. The support vector machine (SVM) model outperformed the logistic regression model and decision tree model in predicting the incidence of early-onset preeclampsia.
Article
Medicine, Research & Experimental
Mingxi Liu, Yue Niu, Kongyang Ma, Peter C. K. Leung, Zi-Jiang Chen, Daimin Wei, Yan Li
Summary: Novel first-trimester serum biomarkers were identified and an effective prediction model for preeclampsia (PE) was developed using immune-related factors and placental growth factor (PlGF), which could aid in the development of early diagnostic strategies for PE and provide new insights into its immunological mechanisms.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Martin R. Salazar, Walter G. Espeche, Carlos E. Leiva Sisnieguez, Julian Minetto, Eduardo Balbin, Adelaida Soria, Osvaldo Yoma, Marcelo Prudente, Soledad Torres, Florencia Grassi, Claudia Santillan, Horacio A. Carbajal
Summary: Nocturnal hypertension is a significant predictor of early-onset preeclampsia in high-risk pregnancies, with a high prevalence among affected women. Office and ambulatory blood pressure measurements show distinct differences between different types of preeclampsia, with a stronger predictive value for early-onset PE.
HYPERTENSION RESEARCH
(2021)
Article
Developmental Biology
Aayushi Hasija, Kirti Balyan, Ekta Debnath, V Ravi, Manisha Kumar
Summary: This study found that in high-risk women for preeclampsia, serum beta hCG levels increased, placental thickness decreased, and uterine artery PI in preeclampsia reached the highest level at 20-24 weeks, making it the best marker.
Article
Endocrinology & Metabolism
Nicoline Callesen Do, Marianne Vestgaard, Bjorg Asbjornsdottir, Lise Lotte Torvin Andersen, Dorte Moller Jensen, Lene Ringholm, Peter Damm, Elisabeth Reinhardt Mathiesen
Summary: In women with preexisting diabetes, both home blood pressure and office blood pressure are positively associated with the development of preeclampsia, and their predictive abilities are comparable. Home blood pressure is lower than office blood pressure in both early and late pregnancy, and the difference increases with increasing office blood pressure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Obstetrics & Gynecology
John K. Chan, Chunqiao Tian, Joshua P. Kesterson, Bradley J. Monk, Daniel S. Kapp, Brittany Davidson, Sharon Robertson, Larry J. Copeland, Joan L. Walker, Robert M. Wenham, Yovanni Casablanca, Nick M. Spirtos, Krishnansu S. Tewari, Jeffrey G. Bell
Summary: The study found that over 70% of patients with high-risk early-stage epithelial ovarian cancer present with one or more symptoms, with the most common being abdominal or pelvic pain. The proportion of women with symptoms and the number of symptoms increase with enlarging tumor size.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Peripheral Vascular Disease
Zenab Mohseni-Alsalhi, Emma B.n.j. Janssen, Jil Delmarque, Sander M. J. van Kuijk, Marc E. A. Spaanderman, Chahinda Ghossein-Doha
Summary: Preeclampsia is associated with cardiac remodeling, leading to an increased risk of heart failure. We developed a prediction model to detect and predict abnormal cardiac remodeling in formerly pregnant women, which may help reduce the risk of clinical heart failure.
Article
Obstetrics & Gynecology
Yuan-Yuan Li, Jing Cao, Jia-Lei Li, Jun-Yan Zhu, Yong-Mei Li, De-Ping Wang, Hong Liu, Hai-Lan Yang, Yin-Fang He, Li-Yan Hu, Rui Zhao, Chu Zheng, Yan-Bo Zhang, Ji-Min Cao
Summary: This study identified high-, medium-, and low-risk clusters of patients with PE based on the severity of persistent PHTN, with each cluster exhibiting distinct clinical characteristics.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Peripheral Vascular Disease
Anna Kivioja, Elli Toivonen, Jaakko Tyrmi, Sanni Ruotsalainen, Samuli Ripatti, Heini Huhtala, Tiina Jaaskelainen, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Tanja Saarela, Hannele Laivuori
Summary: The study found that the polygenic risk score for blood pressure (BP-PRS) is associated with an increased risk of preeclampsia and its severe subtypes, with women with high BP-PRS presenting higher blood pressure values during pregnancy.
Article
Dentistry, Oral Surgery & Medicine
Amira Abdelwhab, Olfat Shaker, Reham Lotfy Aggour
Summary: This study evaluated the expression level of mucin1 in saliva and its correlation with clinical and histological variables in oral potentially malignant disorders and oral squamous cell carcinoma patients. The results showed that mucin1 expression in saliva was significantly elevated in both oral potentially malignant disorders and oral squamous cell carcinoma patients compared with controls, and it correlated with the severity and metastasis of the diseases. These findings suggest that mucin1 in saliva may serve as a potential biomarker for diagnosing these oral diseases.
Article
Biochemistry & Molecular Biology
Ebtsam Hamed Khalil, Olfat G. Shaker, Nabil A. Hasona
Summary: Cancer is a major public health issue globally, and this study aimed to investigate the role of LncRNA H-19 rs2107425 and miR-200a in colorectal cancer susceptibility and correlation in patients with CRC.
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2023)
Article
Cell Biology
Rana Aldabbas, Olfat G. Shaker, Manal F. Ismail, Nevine Fathy
Summary: This study identified the downregulation of miRNA-559 and upregulation of MTDH in psoriatic patients. The levels of PTEN, AKT, and FOXO1 were also found to be significantly altered in psoriasis. miRNA-559 and MTDH may serve as potential diagnostic biomarkers for psoriasis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Letter
Dermatology
Mohammed Hussein Medhat EL-Komy, Khadiga S. S. Sayed, Wedad Z. Z. Mostafa, Olfat Shaker, Nada Nasser, Mohammed Hassan
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ghada Ayeldeen, Olfat G. Shaker, Ahmed M. Khairy, Asharef Y. Elfert, Nabil A. Hasona
Summary: Obesity is associated with a higher risk of colorectal cancer, and chronic inflammation plays a role in this association. The study examines the clinical relevance of microRNA expression and TGF-beta/IL-6 axis in obesity-related colorectal cancer. Diseased individuals showed increased expression of IL-6 and TGF-beta, as well as tumor biomarkers. Obese patients with colorectal cancer had lower expression of microRNAs and a negative correlation with BMI.
NON-CODING RNA RESEARCH
(2023)
Article
Multidisciplinary Sciences
Christine Raouf George Mikhail, Abeer Abd El Maksoud Mohamed, Olfat Gamil Shaker, Eman EL Desouky, Rania Hassan Shalaby
Summary: This study suggests that middle income, previous history of H. pylori, and clinical symptoms of dyspepsia are risk factors for oral H. pylori infection. The prevalence of H. pylori infection in Egypt has declined.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Sameh Fayek GamalEl Din, Olfat Gamil Shaker, Ahmad Fawzy Megawer, Mohamed Ahmed Abdel Salam, Abdelhalim Nabil Abdelhalim, Ahmed Adel
Summary: This study compared the levels of Gal-1 and Gal-3 in seminal plasma and serum between azoospermic patients and fertile men. The results showed significantly higher levels of Gal-1 and Gal-3 in the serum and seminal fluid of azoospermic patients. In healthy individuals, there were significant correlations between these levels and age and reproductive hormones.
ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA
(2023)
Article
Chemistry, Multidisciplinary
Abeer Abd Elmoneam Ali, Salwa M. El-Hallouty, Mohammed Ali El-Desouky
Summary: This study aimed to investigate the role of Punica granatum and Persea Americana extracts in decreasing the neurodegenerative effects of AlCl3 toxicity. The results showed that the treatment with Punica granatum and Persea Americana extracts alleviated the adverse effects of AlCl3 and enhanced dopamine levels while reducing apoptotic markers.
EGYPTIAN JOURNAL OF CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Aya Tarek Salman, Olfat Shaker, Shereen Saeid Elshaer, Ahmed Elshafei
Summary: This study aimed to investigate the expression profile and diagnostic potential of serum miR-92a, 134, and 375 in acute ischemic stroke (AIS) patients. The results showed that miR-92a and miR-375 were downregulated while miR-134 was upregulated. MiR-92a and miR-375 had the highest diagnostic accuracy, with miR-375 being more specific. The findings suggest that miR-92a and miR-375 could serve as potential early biomarkers for AIS.
Article
Dentistry, Oral Surgery & Medicine
Naglaa Mohamed El-Wakeel, Zienab Farid Shalaby, Rania Farouk Abdulmaguid, Sally Said Abd Elhamed, Olfat Shaker
Summary: This study aimed to investigate the levels of prolactin (PRL) in gingival crevicular fluid (GCF), synovial fluid, and serum in patients with moderately active rheumatoid arthritis (RA) with and without periodontitis (P). The study found that patients with periodontitis had higher levels of PRL in GCF and serum, and non-surgical periodontal treatment could reduce these levels.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Medicine, Research & Experimental
Maysa M. Haroon, Gehan A. Hegazy, Mohammed A. Hassanien, Olfat Shaker, Wafaa H. Hussein
Summary: IL23 levels are significantly elevated in SLE patients compared to healthy individuals and are positively correlated with disease activity and parameters of nephritis. Further research is needed to explore its exact role in SLE pathogenesis and its potential as a biomarker or therapeutic target.
BIOLOGICS-TARGETS & THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Elsayed Fouad, Mohamed Abd El-Moneim, Mahmoud El-Desouky, W. I. El-Dougdoug
Summary: New chitosan derivatives were synthesized and evaluated as corrosion inhibitors for mild steel in acidic medium. The inhibition efficiency of these derivatives was found to be high and they were capable of forming a protective film to reduce the corrosion rate.
EGYPTIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ahmed Abdel-Aziz, Mahmoud El-Fransawy, Mahmoud El-Desouky, Rasha A. El-Sadany
Summary: This study investigates the effects of gamma radiation on normal weight concrete and heavyweight concrete, as well as the possibility of replacing steel bars with carbon glass fiber reinforced polymer bars. The results show that heavyweight concrete mixed with barite and ilmenite has better radiation properties than normal weight concrete, and carbon glass fiber bars can safely replace steel bars in structures exposed to gamma radiations.
EGYPTIAN JOURNAL OF CHEMISTRY
(2023)
