Article
Health Care Sciences & Services
Arrigo Fruscalzo, Luigi Viola, Maria Orsaria, Stefania Marzinotto, Michela Bulfoni, Lorenza Driul, Ambrogio P. Londero, Laura Mariuzzi
Summary: This study found altered placental expression and staining pattern of STRA6 in pregnancies complicated by GDM compared to controls. These changes were associated with an altered expression pattern of several other genes involved in retinoid metabolism.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Endocrinology & Metabolism
Rong Huang, Xinxiu Bai, Xueyan Li, Xiaohui Wang, Lina Zhao
Summary: Pancreatic beta-cell dysfunction in type 2 diabetes is influenced by elevated levels of retinol-binding protein 4 (RBP4), which directly suppresses insulin synthesis through the STRA6 pathway. Lowering circulating RBP4 levels could potentially restore beta-cell function and improve hyperglycemia in diabetic mice.
Article
Endocrinology & Metabolism
Ping Wu, Yi Wang, Yi Ye, Xue Yang, Qi Lu, Yan Liu, Huayan Zeng, Xingyue Song, Shijiao Yan, Ying Wen, Xiaorong Qi, Chun-Xia Yang, Gang Liu, Chuanzhu Lv, Xiong-Fei Pan, An Pan
Summary: This study prospectively evaluated the association between circulating RBP4 levels in early pregnancy and the risk of developing GDM in pregnant women. The results showed a positive correlation between serum RBP4 levels in early pregnancy and the risk of GDM, which was confirmed in a meta-analysis. These findings may contribute to a better understanding of the mechanisms underlying the development of GDM.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Endocrinology & Metabolism
Xin Liu, Tao Zheng, Ya-Jie Xu, Meng-Nan Yang, Wen-Juan Wang, Rong Huang, Guang-Hui Zhang, Yu-Na Guo, Jun Zhang, Fengxiu Ouyang, Fei Li, Zhong-Cheng Luo
Summary: This study identified sex-dimorphic associations between GDM, cord plasma FABP4, and estradiol, as well as correlations between FABP4 and adiponectin in newborns. The findings suggest that GDM may affect fetal circulating FABP4 and estradiol levels in males only.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Zhi-Hui Zhang, Jiang-Feng Ke, Jun-Xi Lu, Yun Liu, Ai-Ping Wang, Lian-Xi Li
Summary: This study found that increased serum RBP levels were independently associated with the presence of NAFLD in Chinese T2DM inpatients. This suggests that serum RBP levels may be used as one of the indicators to assess the risk of NAFLD in T2DM patients.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Endocrinology & Metabolism
Abel Valencia-Martinez, Ute Schaefer-Graf, Encarnacion Amusquivar, Emilio Herrera, Henar Ortega-Senovilla
Summary: In pregnant women with gestational diabetes, serum ANGPTL6 levels were increased, along with insulin and apo-RBP4 concentrations. However, there was no correlation observed between circulating ANGPTL6 and glucose or insulin levels in GDM pregnancies. In normal pregnancies, ANGPTL6 levels were associated with maternal glucose homeostasis and fetal adiposity. Further research is needed to understand the mechanism and physiological role of ANGPTL6 in GDM pregnancies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Jiali Xiang, Huajie Dai, Yanan Hou, Qi Wang, Tiange Wang, Mian Li, Zhiyun Zhao, Jieli Lu, Meng Dai, Di Zhang, Yu Xu, Guang Ning, Weiqing Wang, Jiqiu Wang, Yufang Bi, Min Xu
Summary: This study aimed to investigate the association of circulating RBP4 levels with long-term cardiometabolic risk profiles, taking into account sex differences. The results showed that higher RBP4 levels were associated with increased adiposity and deteriorated glucolipid profile. The association differed between men and women regarding 2-h post-loading glucose.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Robin Schuerfeld, Ekaterine Baratashvili, Marleen Wuerfel, Matthias Blueher, Michael Stumvoll, Anke Toenjes, Thomas Ebert
Summary: This study investigated the regulation of ACBP in women with gestational diabetes mellitus (GDM) during pregnancy and postpartum. The results showed that ACBP levels decreased during pregnancy and increased after pregnancy, and ACBP was related to beta cell function and renal markers.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Biochemical Research Methods
Fujia Chen, Min Li, Xiaoping Fei, Xiaohong Chen, Zhaofeng Zhang, Weiqiang Zhu, Yupei Shen, Yanyan Mao, Jun Liu, Jianhua Xu, Jing Du
Summary: The study identified plasma TG and GAL-3BP as potential biomarkers for early prediction and diagnosis of GDM. The combined predictive model of TG and GAL-3BP showed greater diagnostic value than individual GAL-3BP.
JOURNAL OF PROTEOMICS
(2023)
Article
Medicine, General & Internal
Ya-Li Huang, Yen-Lin Chen, Jiunn-Diann Lin, Dee Pei, Pietro Pitrone, Jin-Shuen Chen, Chung-Ze Wu
Summary: This study explored the relationships between adipokines (visfatin and retinol binding protein 4 (RBP4)) and metabolic syndrome (MetS) components in both young-onset type 2 diabetes mellitus (YDM) and late-onset type 2 diabetes mellitus (ODM) patients. The results showed that visfatin levels were significantly higher in YDM patients compared to ODM patients, while RBP4 levels did not differ significantly. In YDM patients, visfatin was negatively correlated with fasting plasma glucose, while RBP4 was positively correlated with triglyceride. In ODM patients, the only positive relationship found was between RBP4 and diastolic blood pressure.
MEDICINA-LITHUANIA
(2023)
Review
Nutrition & Dietetics
Jialin Lu, Dandan Wang, Baolan Ma, Xiaochun Gai, Xiao Kang, Jinyu Wang, Ke Xiong
Summary: A systematic review and meta-analysis found that blood retinol concentration was negatively associated with type I diabetes mellitus and gestational diabetes mellitus, while blood retinol-binding protein concentration was positively associated with type II diabetes mellitus and gestational diabetes mellitus.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Endocrinology & Metabolism
Guo-bao Hong, Xiao-fei Shao, Jia-min Li, Qin Zhou, Xiao-Su Ke, Pei-Chun Gao, Xiao-Lin Li, Jing Ning, Hai-Shan Chen, Hua Xiao, Chong-Xiang Xiong, Hequn Zou
Summary: This study found that RBP4 is strongly associated with hyperuricemia, and its predictive value was higher than that of traditional predictors. The optimum predictive model for hyperuricemia in the general population included RBP4, sex, body mass index, serum creatinine, high-sensitivity C-reactive protein, fasting blood glucose, insulin, and alcohol consumption.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Richard Vollenberg, Phil-Robin Tepasse, Manfred Fobker, Anna Husing-Kabar
Summary: RBP4 plasma levels are significantly reduced in critically ill COVID-19 patients during acute inflammation, and vitamin A levels are significantly reduced in patients with moderate/severe/critical illness during the acute phase of illness.
Review
Biochemistry & Molecular Biology
Mateusz Kunysz, Olimpia Mora-Janiszewska, Dorota Darmochwal-Kolarz
Summary: This article summarizes the data on epigenetic changes in pregnant women with gestational diabetes in relation to endocrine disrupting chemicals, emphasizing the potential impact of environmental exposure on the development of GDM. There is a suggestion that epigenetic marks could potentially serve as a useful tool for diagnostic, prognostic, and therapeutic purposes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Haihua Shan, Yanjing Ji, Haibo Gu, Hui Li, Jing Zhu, Yu Feng, Hao Peng, Tao You, Xiaosong Gu
Summary: The study found that serum RBP4 levels were higher in diabetic cardiomyopathy (DCM) patients compared to diabetic patients without DCM or controls. Multivariate analysis and restricted cubic splines (RCS) showed a significant association between RBP4 and DCM.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Alexander Kautzky, Kathrin Heneis, Karin Stengg, Sabine Froehlich, Alexandra Kautzky-Willer
Summary: The study explores the interplay of psychological stress, biological markers, anthropometric measures, and gender roles in relation to metabolic and hormonal parameters. Burnout and perceived stress were associated with insulin secretion, cortisol levels, thyroid-stimulating hormone, anthropometric measures, and gender role. Results suggest that female self-identification may impact BMI, body fat, and fatty liver index, highlighting the importance of considering gender-related factors in clinical risk assessment for obese women.
NEUROENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Michael Leutner, Caspar Matzhold, Luise Bellach, Evelyne Wohlschlager-Krenn, Robert Winker, Sonja Nistler, Georg Endler, Stefan Thurner, Peter Klimek, Alexandra Kautzky-Willer
Summary: A study found that in patients with prediabetes, testosterone levels in males were associated with more favorable glucose metabolism, while no such relationship was found in females.
WIENER KLINISCHE WOCHENSCHRIFT
(2022)
Article
Endocrinology & Metabolism
Carsten T. Herz, Oana C. Kulterer, Marlene Prager, Christoph Schmoltzer, Felix B. Langer, Gerhard Prager, Rodrig Marculescu, Alexandra Kautzky-Willer, Marcus Hacker, Alexander R. Haug, Florian W. Kiefer
Summary: This cross-sectional study found that individuals with severe obesity and active brown adipose tissue (BAT) have a healthier metabolic profile, characterized by lower visceral fat mass, decreased insulin resistance, lower systemic inflammation, and improved nonalcoholic fatty liver disease parameters.
Article
Health Care Sciences & Services
Alexandra Kautzky-Willer, Michaela Kaleta, Simon D. Lindner, Michael Leutner, Stefan Thurner, Peter Klimek
Summary: This study validates the reported male predominance and higher mortality rate in hospitalised COVID-19 patients. It identifies specific factors that influence mechanical ventilation and death outcomes, and highlights the importance of considering sex-specific strategies in managing and preventing COVID-19.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Chemistry, Analytical
Paul Fellinger, Karin Rodewald, Moritz Ferch, Bianca Itariu, Alexandra Kautzky-Willer, Yvonne Winhofer
Summary: This study aimed to investigate the accordance between glucose management indicator (GMI) and HbA1c in patients with diabetes using intermittent scanning CGM (isCGM). It was found that there was a certain degree of discordance between GMI and HbA1c, which was more pronounced in patients with increased BMI and type 2 diabetes (T2DM).
Article
Virology
Faisal Aziz, Hannah Stocher, Alexander Brauer, Christian Ciardi, Martin Clodi, Peter Fasching, Mario Karolyi, Alexandra Kautzky-Willer, Carmen Klammer, Oliver Malle, Felix Aberer, Erich Pawelka, Slobodan Peric, Claudia Ress, Caren Sourij, Lars Stechemesser, Harald Stingl, Thomas Stulnig, Norbert Tripolt, Michael Wagner, Peter Wolf, Andreas Zitterl, Othmar Moser, Christian Schelkshorn, Susanne Kaser, Harald Sourij
Summary: This study assessed the predictive performance of inflammatory, hepatic, coagulation, and cardiac biomarkers in patients with prediabetes and diabetes mellitus hospitalized for COVID-19 in Austria. Troponin T showed excellent predictive performance, while NT-proBNP showed good predictive performance for assessing in-hospital mortality in patients with diabetes mellitus hospitalized with COVID-19.
Article
Psychology, Clinical
Carola Deischinger, Dorota Slukova, Ivica Just, Ulrike Kaufmann, Juergen Harreiter, Mick van Trotsenburg, Siegfried Trattnig, Martin Krssak, Alexandra Kautzky-Willer, Radka Klepochova, Lana Kosi-Trebotic
Summary: This study aimed to investigate the effect of gender-affirming hormone therapy on cardiovascular disease risk factors, with a focus on glucose tolerance. The study found that estrogen intake was associated with higher insulin resistance in transgender individuals assigned male at birth. Transgender males displayed increased heart rate but a more favorable fat ratio compared to cisgender males. Monitoring for the development of insulin resistance is necessary for transgender individuals assigned male at birth.
INTERNATIONAL JOURNAL OF TRANSGENDER HEALTH
(2023)
Review
Endocrinology & Metabolism
Alexandra Kautzky-Willer, Michael Leutner, Jurgen Harreiter
Summary: The prevalence of type 2 diabetes is increasing in both sexes, but men are diagnosed at a younger age and lower body fat mass than women. Worldwide, there are about 17.7 million more men than women with diabetes. Women are at a greater risk for obesity at the time of type 2 diabetes diagnosis and psychosocial stress may play a more prominent role in their diabetes risk.
Correction
Endocrinology & Metabolism
Alexandra Kautzky-Willer, Michael Leutner, Juergen Harreiter
Review
Nutrition & Dietetics
Maria del Carmen Macias Ruiz, Lorena Cuenca Bermejo, Nicola Veronese, Emiliano Fernandez Villalba, Ana Maria Gonzalez Cuello, Karolina Kublickiene, Valeria Raparelli, Colleen M. Norris, Alexandra Kautzky-Willer, Louise Pilote, Mario Barbagallo, Ligia Dominguez, Maria Trinidad Herrero
Summary: This article reviews the role of magnesium in health and illness, with emphasis on the elderly population with chronic kidney disease (CKD) and potential sex differences. It is found that magnesium can be used as an adjunctive treatment for CKD patients to improve glomerular filtration, but further research and characterization are needed for its clinical applications. Therefore, well-designed prospective clinical trials are needed to establish guidelines for magnesium supplementation, considering age and sex.
Article
Biology
Lorena Cuenca-Bermejo, Maria Josefa Fernandez-Del Palacio, Valeria de Cassia Goncalves, Victor Bautista-Hernandez, Consuelo Sanchez-Rodrigo, Emiliano Fernandez-Villalba, Karolina Kublickiene, Valeria Raparelli, Alexandra Kautzky-Willer, Colleen M. Norris, Louise Pilote, Maria Trinidad Herrero
Summary: Cardiovascular diseases are a leading cause of death and illness worldwide, with age being an important risk factor. Preclinical models are crucial for understanding cardiac changes related to aging and pathological aspects. In this study, the cardiac electric activity was evaluated in the Octodon degus rodent model during aging, considering differences between males and females. The results showed that both age and sex influence cardiac function and the incidence of arrhythmias, suggesting the potential usefulness of this model for cardiovascular research, including impacts of aging and biological sex.
Article
Multidisciplinary Sciences
Donald Ruggiero Lo Sardo, Stefan Thurner, Johannes Sorger, Georgh Heiler, Michael Gyimesi, Alexander Kautzky, Michael Leutner, Alexandra Kautzky-Willer, Peter Klimek
Summary: The prevalence of diseases varies greatly from region to region, and the factors driving these variations are largely unknown. This study examines how demographic, socio-economic, environmental factors, migratory background, and access to healthcare services relate to regional prevalence variations in 115 different diseases. The study finds that certain diseases can be explained up to 80% by these risk factors, while for others, the explanatory power is close to zero. Additionally, access to healthcare facilities, especially for chronic diseases like diabetes, significantly contributes to the disease risk.
Article
Nutrition & Dietetics
Luise Bellach, Liliana-Imi Gard, Simon David Lindner, Sabina Baumgartner-Parzer, Peter Klimek, Alexandra Kautzky-Willer, Michael Leutner
Summary: This study investigates the relationship between adipokines and glucose metabolism during pregnancy post-RYGB-OP and found that adipokines such as leptin are associated with glucose metabolism and body composition.
Article
Multidisciplinary Sciences
Michaela Kaleta, Michael Leutner, Stefan Thurner, Alexander Kautzky, Gottfried Endel, Noemi Kiss, Martin Robausch, Alexandra Kautzky-Willer, Peter Klimek
Summary: Undernutrition in early life is associated with an increased risk of type 2 diabetes in later life. This study investigates the impact of perinatal exposure to famines on the risk of developing type 2 diabetes. The findings show that famine-related birth cohorts have a significantly higher incidence rate of diabetes compared to cohorts born two years earlier, suggesting the importance of reproductive health and proper nutrition during pregnancy and early postnatal life in efforts to decrease the prevalence of diabetes.
Article
Cardiac & Cardiovascular Systems
Rubee Dev, Divine Favour-Ofili, Valeria Raparelli, Hassan Behlouli, Zahra Azizi, Karolina Kublickiene, Alexandra Kautzky-willer, Maria Trinidad Herrero, Louise Pilote, Colleen M. Norris
Summary: There is a rise in cardiovascular diseases in sub-Saharan Africa, and gender-related factors play a role in the development of these diseases. Females have higher prevalence rates of hypertension and overweight/obesity compared to males, resulting in poorer cardiovascular health for females.
