Review
Endocrinology & Metabolism
Yamei Xue, Xiaohong Cheng, Yuping Xiong, Kun Li
Summary: This review summarizes and discusses the mutations of nine important genes associated with fertilization failure in infertile patients. The review highlights their roles in the fertilization process and suggests these mutations as potential targets for precision treatments in reproductive medicine. Furthermore, the review provides helpful clues for genetic counseling and optimizing clinical treatments for human infertility by supplying timely information on the genetic causes of fertilization failure.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Robert John Norman
Summary: Intracytoplasmic sperm injection (ICSI) was initially introduced for male infertility but is now widely used in assisted reproduction techniques. The indications for ICSI use need to be re-evaluated to ensure appropriate application in infertility management.
FERTILITY AND STERILITY
(2022)
Review
Endocrinology & Metabolism
Linna Ma, Yurong Cao, Yue Ma, Jun Zhai
Summary: The association between hyperandrogenism and adverse pregnancy outcomes was studied in patients with different polycystic ovary syndrome phenotypes undergoing IVF/ICSI. The results indicated that hyperandrogenism may have negative effects on clinical pregnancy and miscarriage outcomes, particularly among Asian populations.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Ning Huang, Lixue Chen, Ying Lian, Haining Wang, Rong Li, Jie Qiao, Hongbin Chi
Summary: The presence of thyroid autoimmunity in patients with infertility did not impair embryo quality or affect pregnancy outcomes, including clinical pregnancy, miscarriage, preterm delivery, and live birth. However, it decreased the number of oocytes retrieved and birth weight in twin pregnancy. Subgroup analysis showed no association between the types or titers of thyroid antibodies and adverse IVF/ICSI outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Huixiao Chen, Ping Sun, Na Zhang, Shangge Lv, Yongzhi Cao, Lei Yan
Summary: This study assessed the effect of uterine septum resection on reproductive outcomes in patients with secondary infertility undergoing in vitro fertilization/intracytoplasmic sperm injection. The results showed that uterine septum resection improved the pregnancy rates and live birth rates in these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Obstetrics & Gynecology
Wen Yao, Ying Chen, Haixia Yao, Qingyun Yao, Lan Wang, Meng Wang, Jing Yue
Summary: This retrospective cohort study investigated the relationship between uterine niche and reproductive outcomes of IVF/ICSI. The study found that women with uterine niche had lower live birth rate, positive HCG test rate, clinical pregnancy rate, and implantation rate during IVF/ICSI treatment. The study highlights the negative impact of uterine niche on fertility outcomes in women with cesarean section history.
FERTILITY AND STERILITY
(2023)
Article
Endocrinology & Metabolism
Yalong Liu, Zining He, Ning Huang, Lin Zeng, Yang Wang, Rong Li, Hongbin Chi
Summary: This study aimed to investigate the impact of thyroid autoimmunity and total 25-hydroxyvitamin D concentration on early pregnancy outcomes in women undergoing in vitro fertilization/intracytoplasmic sperm injection. The study found that patients with thyroid autoimmunity had lower vitamin D serum concentrations and fewer good-quality embryos. Aging was also found to adversely affect clinical and ongoing pregnancy in this population.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Fangying Chen, Yixin Chen, Qinyun Mai
Summary: Methylation profiles in cumulus cells (CCs) were found to be associated with pregnancy outcomes in women undergoing intracytoplasmic sperm injection-in vitro fertilization (ICSI-IVF) procedures. Machine learning approaches were used to establish a prediction model, and gene set analyses and pathway analysis provided validation for the importance of methylated genes.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Veterinary Sciences
Effrosyni Fatira, Milos Havelka, Taiju Saito, Jose Landeira, Marek Rodina, David Gela, Martin Psenicka
Summary: In this study, the researchers applied intracytoplasmic sperm injection (ICSI) technology to endangered sturgeons and found that it successfully produced embryos and larvae. Furthermore, molecular analysis showed genome integration of both egg and sperm donor species, demonstrating the potential of ICSI for assisted reproduction in sturgeons.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Endocrinology & Metabolism
Ning Huang, Lin Zeng, Jie Yan, Hongbin Chi, Jie Qiao
Summary: In women undergoing IVF/ICSI treatment, a history of thyroid cancer may decrease the number of retrieved oocytes and high-grade embryos, but does not impact pregnancy outcomes or increase the risk of adverse obstetric outcomes.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Hanglin Wu, Songying Zhang, Xiaona Lin, Shasha Wang, Ping Zhou
Summary: The study found that delays in progesterone supplementation until 96 hours after oocyte retrieval did not affect pregnancy outcomes. The combination of progesterone and gonadotropin-releasing hormone agonists showed significant benefits for live birth. Comparisons between active LPS treatments showed small and uncertain differences in efficacy and tolerability.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Review
Obstetrics & Gynecology
Jingsi Chen, Jia Bie, Fangjie Jiang, Yanzhi Wu, Zhengmei Pan, Yushi Meng, Jiamei Song, Yang Liu
Summary: This meta-analysis aimed to evaluate the efficacy and safety of LMWH on pregnancy outcomes in thrombophilic women receiving IVF/ICSI. The results showed that LMWH administration was associated with higher clinical pregnancy rate, implantation rate, and live birth rate, but lower miscarriage rate. However, it was also linked to a higher risk of bleeding events.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Alessandro Ghidini, Manisha Gandhi, Jennifer McCoy, Jeffrey A. Kuller
Summary: This article discusses the management of pregnancies achieved with in vitro fertilization and provides recommendations for genetic counseling, prenatal screening and diagnostic testing, ultrasound examination, fetal echocardiography, placental evaluation, cervical length assessment, fetal growth assessment, low-dose aspirin use, antenatal fetal surveillance, and timing of delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Endocrinology & Metabolism
Yuqing Jiang, Zhaoyang Shen, Jianmin Xu, Jing Zhu, Huan Wang, Wenhui Chen, Yingpu Sun, Qingling Yang
Summary: High sperm DNA fragmentation index (DFI) in overweight/obese women during ICSI cycles leads to decreased fertilization, cleavage, and high-quality embryo rates. The diminished capacity of oocytes to repair sperm DNA damage may be the cause of the decreased early developmental potential in embryos from overweight/obese patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Liang Chen, Hanjing Zhou, Xueli Liu, Jing Zhao, Qianrong Qi, Qingzhen Xie
Summary: This study analyzed early rescue intracytoplasmic sperm injection (r-ICSI) cycles in normal and hyper-ovarian response women and compared their cycle characteristics, pregnancy, and neonatal outcomes. The results showed that partial r-ICSI cycles had different characteristics compared to total r-ICSI cycles, and early r-ICSI delayed blastocyst development. In fresh cleavage-stage embryo transfer cycles, there was no significant difference in pregnancy and live birth rates among the groups, but reduced pregnancy outcomes were observed in fresh blastocyst transfer cycles. Early r-ICSI did not have a negative impact on preterm birth, Cesarean section, neonatal birth weight, and sex ratio.
JOURNAL OF CLINICAL MEDICINE
(2023)
