Journal
PROTEIN SCIENCE
Volume 24, Issue 9, Pages 1543-1548Publisher
WILEY
DOI: 10.1002/pro.2717
Keywords
odorant receptor; sequence; structure; binding cavity; olfactory
Categories
Funding
- APEX Region PACA (OLFACTOME)
- Fondation Roudnitska under aegis of Fondation de France
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Odorant receptors (ORs) are the largest subfamily within class A G protein-coupled receptors (GPCRs). No experimental structural data of any OR is available to date and atomic-level insights are likely to be obtained by means of molecular modeling. In this article, we critically align sequences of ORs with those GPCRs for which a structure is available. Here, an alignment consistent with available site-directed mutagenesis data on various ORs is proposed. Using this alignment, the choice of the template is deemed rather minor for identifying residues that constitute the wall of the binding cavity or those involved in G protein recognition.
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