Article
Endocrinology & Metabolism
G. Tavares, D. Marques, C. Barra, D. Rosendo-Silva, A. Costa, T. Rodrigues, P. Gasparini, B. F. Melo, J. F. Sacramento, R. Seica, S. V. Conde, P. Matafome
Summary: The study investigated the dopamine receptors expression in adipose tissue of patients with T2D and the therapeutic effects of bromocriptine in modulating metabolism in this tissue. Patients with insulin resistance showed decreased DRD1 and DRD4 expression, while bromocriptine treatment in diabetic rats increased D1R and TH levels, leading to higher insulin sensitivity and improved metabolic status. Bromocriptine treatment remodeled the adipose tissue and liver dopaminergic system, resulting in enhanced insulin sensitivity and catabolic function.
MOLECULAR METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Xin Liu, Zhao-Yan Cheng, Yan-Feng Li, Chao Liu, Xiao-Jian Gong, Ling He
Summary: This study found that the DRD2 agonist bromocriptine can improve A beta 1-42 induced neuroinflammation and memory deficits through the DRD2/beta-arrestin 2/PP2A/JNK signaling axis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Leili Mortazavi, Tristan J. Hynes, Chloe S. Chernoff, Shrishti Ramaiah, Hannah G. Brodie, Brittney Russell, Brett A. Hathaway, Sukhbir Kaur, Catharine A. Winstanley
Summary: Dopamine agonist therapies used to treat Parkinson's disease can exacerbate impulse control and gambling disorders, but the underlying mechanisms are unclear. Recent studies have found that adding win-paired cues to the rat gambling task increases risky decision-making and impulsivity via the dopamine system. Ropinirole treatment in male rats transiently increased motor impulsivity and choice of high-risk/high-reward options, especially during acquisition of the cued gambling task. The drug enhanced model-free learning and suppressed the activity of dopaminergic midbrain neurons, leading to perpetuated risky choice.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Anahid Hamidianjahromi, Nicholas A. Tritos
Summary: Dopamine agonists (DAs), commonly used for hyperprolactinemia and prolactinomas, may lead to impulse control disorders (ICDs) such as gambling addiction, compulsive shopping, and hypersexuality. Diagnosing ICDs in patients receiving DAs requires suspicion and screening questionnaires. Patients with ICDs should discontinue or reduce DA therapy and receive psychiatric consultation and cognitive behavioral therapy.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Biology
Suchan Chang, Yeonhee Ryu, Se Kyun Bang, Han Byeol Jang, DanBi Ahn, Hyung Kyu Kim, Hubert Lee, Sang Chan Kim, Bong Hyo Lee, Hee Young Kim
Summary: Drug addiction is a global problem, with most studies focusing on the central nervous system. However, this research reveals that cocaine injection increases peripheral body temperature, and that this increase is associated with the activation of dopamine D2 receptors.
Article
Ophthalmology
Joel D. Bowen, Carissa V. Alforque, Michael A. Silver
Summary: This study investigated the effects of involuntary and voluntary spatial attention on a crowding task using an anticueing paradigm. The results showed that involuntary attention capture led to faster response times and smaller critical spacing when the target appeared on the cued side, while voluntary attention allocation resulted in faster reaction times but no significant effect on critical spacing when the target appeared on the opposite side to the cue.
Article
Cardiac & Cardiovascular Systems
Marianne F. Clausen, Rasmus Rorth, Christian Torp-Pedersen, Lucas Malta Westergaard, Peter E. Weeke, Gunnar Gislason, Lars Kober, Emil Fosbol, Soren Lund Kristensen
Summary: This study investigated the impact of bromocriptine treatment on heart valve disease in young women, finding that pre-treatment echocardiographic screening has low clinical yield in this patient population.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Clinical Neurology
D'bora Dreher Nabinger, Stefani Altenhofen, Alexis Buatois, Amanda Facciol, Julia Vasconcellos Peixoto, Julia Maria Kuhl da Silva, Diptendu Chatterjee, Gabriel Rubensam, Robert Gerlai, Carla Denise Bonan
Summary: This study investigated the effects of the dopamine D2/D3 receptor agonist quinpirole on the behavior, brain-derived neurotrophic factor (BDNF), and neurotransmitter levels in adult zebrafish. The results showed that quinpirole administration caused decreased locomotor activity, increased anxiety-like behaviors, memory impairment, and stereotypic swimming in zebrafish. Furthermore, quinpirole treatment also decreased the number of BDNF-immunoreactive cells and altered glutamate and serotonin levels in the zebrafish brain. These findings suggest that quinpirole administration in adult zebrafish can be a useful tool for studying the mechanisms underlying neurological disorders related to the dopaminergic system.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Nina M. Hanning, Marc M. Himmelberg, Marisa Carrasco
Summary: There are striking polar performance asymmetries in visual performance, both during eye fixation and saccade preparation. However, instead of alleviating these asymmetries, presaccadic attention exacerbates them.
Article
Endocrinology & Metabolism
Matheo Augusto Morandi Stumpf, Felipe Moura Maia Pinheiro, Gilberto Ochman Silva, Valter Angelo Sperling Cescato, Nina Rosa Castro Musolino, Malebranche Berardo Carneiro Cunha-Neto, Andrea Glezer
Summary: Dopamine agonists (DA) are the preferred treatment for prolactinoma and hyperprolactinemia. However, intolerance to DA can occur in 3 to 12% of cases, leading to treatment discontinuation. This review discusses the definition, pathogenesis, frequency, and management of DA intolerance, as well as introduces a case report on the use of intravaginal cabergoline.
Article
Chemistry, Multidisciplinary
Syed Awais Ali Zaidi, Mahtab Ahmad Khan, Muhammad Rizwan Khan, Hammad Ahmed, Zaib Ali Shahryar, Muhammad Umar Khayam Sahibzada, Saad Alghamdi, Abdulelah Aljuaid, Mazen Almehmadi, Mamdouh Allahyani
Summary: Parkinson's disease is a progressive neurological disorder that affects movement. This study found that Benzoic-D5 shows potential in ameliorating the symptoms of Parkinson's disease in mice.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Review
Endocrinology & Metabolism
Yunzhi Zou, Depei Li, Jiayu Gu, Siyu Chen, Xia Wen, Jiajun Dong, Xiaobing Jiang
Summary: The study revealed a very low recurrence rate of prolactinomas after withdrawal of DAs, with a recurrence proportion of 2%. More prospective studies with larger sample sizes and longer follow-up periods are encouraged to confirm this finding.
BMC ENDOCRINE DISORDERS
(2021)
Article
Clinical Neurology
Alexander Kaltenboeck, Don Chamith Halahakoon, Catherine J. Harmer, Philip Cowen, Michael Browning
Summary: Healthy volunteers who received subacute pramipexole treatment exhibited higher taste recognition performance and sensitivity, as well as decreased hedonic responses to taste samples.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Andrea Ramos de Castro Moreira, Ericka Trarbach, Cristina Bellotti Formiga Bueno, Anna Louise Stellfeld Monteiro, Isabella Pacetti Pajaro Grande, Mario Padula, Gustavo Arantes Rosa Maciel, Andrea Glezer
Summary: In this study, six PRL-R variants associated with prolactinomas were identified, with two variants showing higher frequency in patients compared to the genomic database. These variants were associated with male sex, higher serum PRL levels, larger tumors, and cabergoline resistance. These findings suggest the involvement of the prolactin/prolactin receptor system in prolactinoma tumorigenesis and resistance to cabergoline.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Foteini Vartzoka, Elif Ozenoglu, Nikolaos Pitsikas
Summary: Multiple lines of evidence suggest that the lack of nitric oxide (NO) is associated with the development of schizophrenia. A compound called molsidomine, which can restore NO levels, may be useful for treating this disorder. This study aimed to investigate the effectiveness of molsidomine and its combination with non-typical antipsychotics clozapine and risperidone in countering memory deficits caused by dysregulation of the brain's dopaminergic system in rats.
