Structural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus

Exceptional potency and structural basis of a T1249-derived lipopeptide fusion inhibitor against HIV-1, HIV-2, and simian immunodeficiency virus

(2018) Yuanmei Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fusion Inhibitory Lipopeptides Engineered for Prophylaxis of Nipah Virus in Primates

(2018) Cyrille Mathieu et al.   JOURNAL OF INFECTIOUS DISEASES

Design of Novel HIV-1/2 Fusion Inhibitors with Efficient Therapeutic Efficacy in Rhesus Monkey Models

(2018) Huihui Chong et al.   JOURNAL OF VIROLOGY

Enfuvirtide (T20)-Based Lipopeptide Is a Potent HIV-1 Cell Fusion Inhibitor: Implications for Viral Entry and Inhibition

(2017) Xiaohui Ding et al.   JOURNAL OF VIROLOGY

A Lipopeptide HIV-1/2 Fusion Inhibitor with Highly Potent In Vitro , Ex Vivo , and In Vivo Antiviral Activity

(2017) Huihui Chong et al.   JOURNAL OF VIROLOGY

Development of potent and long-acting HIV-1 fusion inhibitors

(2016) Huihui Chong et al.   AIDS

A Helical Short-Peptide Fusion Inhibitor with Highly Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus

(2016) Shengwen Xiong et al.   JOURNAL OF VIROLOGY

Design of a highly potent HIV-1 fusion inhibitor targeting the gp41 pocket

(2015) Huihui Chong et al.   AIDS

The N-Terminal T–T Motif of a Third-Generation HIV-1 Fusion Inhibitor Is Not Required for Binding Affinity and Antiviral Activity

(2015) Huihui Chong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanism of HIV-1 Resistance to Short-Peptide Fusion Inhibitors Targeting the Gp41 Pocket

(2015) Yang Su et al.   JOURNAL OF VIROLOGY

The M-T hook structure increases the potency of HIV-1 fusion inhibitor sifuvirtide and overcomes drug resistance

(2014) Huihui Chong et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Two M-T hook residues greatly improve the antiviral activity and resistance profile of the HIV-1 fusion inhibitor SC29EK

(2014) Huihui Chong et al.   Retrovirology

An ancestral HIV-2/simian immunodeficiency virus peptide with potent HIV-1 and HIV-2 fusion inhibitor activity

(2013) Pedro Borrego et al.   AIDS

Synthesized Peptide Inhibitors of HIV-1 gp41-dependent Membrane Fusion

(2013) Yuxian He   CURRENT PHARMACEUTICAL DESIGN

Sphingopeptides: dihydrosphingosine-based fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1

(2012) Avraham Ashkenazi et al.   FASEB JOURNAL

Short-peptide fusion inhibitors with high potency against wild-type and enfuvirtide-resistant HIV-1

(2012) Huihui Chong et al.   FASEB JOURNAL

Discovery of Critical Residues for Viral Entry and Inhibition through Structural Insight of HIV-1 Fusion Inhibitor CP621–652

(2012) Huihui Chong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Broad Antiviral Activity and Crystal Structure of HIV-1 Fusion Inhibitor Sifuvirtide

(2012) Xue Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Potent and Broad HIV-1 Fusion Inhibitor CP32M

(2012) Xue Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The M-T Hook Structure Is Critical for Design of HIV-1 Fusion Inhibitors

(2012) Huihui Chong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of HIV-1 by Fusion Inhibitors

(2010) Dirk Eggink et al.   CURRENT PHARMACEUTICAL DESIGN

Peptide-Based Inhibitors of the HIV Envelope Protein and Other Class I Viral Fusion Proteins

(2010) Imke Steffen et al.   CURRENT PHARMACEUTICAL DESIGN

Viral Entry Inhibitors Targeted to the Membrane Site of Action

(2010) M. Porotto et al.   JOURNAL OF VIROLOGY

Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potency

(2009) P. Ingallinella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane-Anchored HIV-1 N-Heptad Repeat Peptides Are Highly Potent Cell Fusion Inhibitors via an Altered Mode of Action

(2009) Yael Wexler-Cohen et al.   PLoS Pathogens

Design and Evaluation of Sifuvirtide, a Novel HIV-1 Fusion Inhibitor

(2008) Yuxian He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Critical Motif for the Human Immunodeficiency Virus Type 1 (HIV-1) gp41 Core Structure: Implications for Designing Novel Anti-HIV Fusion Inhibitors

(2008) Y. He et al.   JOURNAL OF VIROLOGY

Potent HIV fusion inhibitors against Enfuvirtide-resistant HIV-1 strains

(2008) Y. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA