Article
Immunology
Lukman O. Afolabi, Jiacheng Bi, Xuguang Li, Adeleye O. Adeshakin, Funmilayo O. Adeshakin, Haisi Wu, Dehong Yan, Liang Chen, Xiaochun Wan
Summary: The pan-HDAC inhibitor panobinostat demonstrated anti-tumor and anti-proliferative activities on various tumors in vitro and when combined with NK cells, showed synergistic effects in mediating tumor cell cytolysis. Mechanistically, panobinostat treatment increased expression of cell adhesion and tight junction-related genes, promoted conjugation formation between NK and tumor cells, and modulated NK cell-activating receptors and ligands on tumor cells, contributing to enhanced tumor cytolysis. Overall, panobinostat therapy exhibited better tumor control and synergized with anti-PD-L1 therapy, highlighting its potential in enhancing NK cell-based immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yiying Zhu, Zhangxun Zhao, Minggao Xue, Dan Wang, Guifeng Su, Xiaoman Ju, Qihong Yang, Shaohua Zhang, Dongmei Fan, Huifang Zhu, Min Yu, Yan Li, Lingmei Kong, Hongyu Zhou
Summary: Activation of the NKG2D receptor can enhance the sensitivity of leukemia cells to NK cell cytotoxicity, and this can be achieved through the use of drugs such as Ciclopirox Olamine (CPX). CPX can increase the expression of NKG2D ligands (NKG2DLs) on leukemia cells, thereby enhancing the efficacy of NK cell-mediated immunotherapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Ante Ou, Yuewei Wang, Jiaxin Zhang, Yongzhuo Huang
Summary: Brain diseases are a significant global healthcare burden. The blood-brain barrier poses challenges for delivering therapeutics into the brain parenchyma. To overcome this, cell and cell derivative-based drug delivery systems have gained interest due to their biocompatibility, low immunogenicity, and ability to penetrate the blood-brain barrier. This review provides an overview of recent advancements in these delivery systems for brain disease diagnosis and treatment, as well as the challenges and potential solutions for clinical translation.
Article
Immunology
Anne B. Kristensen, Kathleen Wragg, Hillary Vanderven, Wen Shi Lee, Julie Silvers, Helen E. Kent, Michael D. Grant, Anthony D. Kelleher, Jennifer A. Juno, Stephen J. Kent, Matthew S. Parsons
Summary: Highly differentiated CD57(+)NKG2C(+) NK cells are abundant in HIV-1-infected individuals and show strong responses to viral antibody stimuli, suggesting a potential role in HIV-1 pathogenesis or therapeutic strategies.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Immunology
Qian-Nan Shang, Xing-Xing Yu, Zheng-Li Xu, Yu-Hong Chen, Ting-Ting Han, Yuan-Yuan Zhang, Meng Lv, Yu-Qian Sun, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xiang-Yu Zhao, Xiao-Jun Huang
Summary: Expanded NK cells have stronger anti-HCMV function compared to primary NK cells, exhibiting higher cytotoxicity and better inhibition of HCMV propagation both in vitro and in vivo.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Oncology
Melanie Gauthier, Caroline Laroye, Daniele Bensoussan, Cedric Boura, Veronique Decot
Summary: Monoclonal antibodies targeting tumors and the cooperation with NK cells play a crucial role in enhancing the efficacy of antibody therapy in cancer treatment.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rongzhang He, Xingyu Zheng, Jian Zhang, Bo Liu, Qijie Wang, Qian Wu, Ziyan Liu, Fangfang Chang, Yabin Hu, Ting Xie, Yongchen Liu, Jun Chen, Jing Yang, Shishan Teng, Rui Lu, Dong Pan, You Wang, Liting Peng, Weijin Huang, Velislava Terzieva, Wenpei Liu, Youchun Wang, Yi-Ping Li, Xiaowang Qu
Summary: The study found that spike-specific CXCR3(+) T-FH cells play a crucial role in antibody maintenance and recall responses after SARS-CoV-2 infection and vaccination, exhibiting a more durable response and better ability to induce antibody secretion.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Multidisciplinary Sciences
Timon Damelang, Elizabeth H. Aitken, Wina Hasang, Ester Lopez, Martin Killian, Holger W. Unger, Ali Salanti, Alexis Shub, Elizabeth McCarthy, Katherine Kedzierska, Martha Lappas, Stephen J. Kent, Stephen J. Rogerson, Amy W. Chung
Summary: The study investigated the impact of antibodies in pregnant women on malaria during pregnancy, finding that the anti-inflammatory effect of antibodies during pregnancy may weaken the immune response to placental malaria.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Seong-Hoon Kim, Mi-Jin Kim, Mina Lim, Jihye Kim, Hyunmin Kim, Chang-Koo Yun, Yun-Joo Yoo, Youngjun Lee, Kyunghoon Min, Yong-Soo Choi
Summary: Conventional natural killer (NK)-based anticancer immunotherapy requires a 2-week culture period to enhance the activity and number of NK cells. By transferring allogeneic mitochondria into NK cells, we significantly enhanced their activity and cytotoxicity. This approach could offer a timely therapeutic strategy for cancer treatment without the need for time-consuming and costly in vitro culture.
Article
Oncology
Daun Jung, Young Seok Baek, In Jee Lee, Ki Yeon Kim, Heejoo Jang, Sohyun Hwang, Jieun Jung, Yong-wha Moon, Kyung-Soon Park, Yong-Soo Choi, Hee Jung An
Summary: This study focused on ex vivo expansion and cryopreservation of allogeneic NK cells, which showed upregulated genes related to NK cell functions and exhibited potent cytolytic activity against cancer cell lines. The research suggests the potential use of expanded and cryopreserved NK cells as a promising immunotherapy for drug-resistant cancer patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Rene Yu-Hong Cheng, King L. Hung, Tingting Zhang, Claire M. Stoffers, Andee R. Ott, Emmaline R. Suchland, Nathan D. Camp, Iram F. Khan, Swati Singh, Ying-Jen Yang, David J. Rawlings, Richard G. James
Summary: This study demonstrates the potential of ex vivo engineered and differentiated human plasma cells for long-term protein secretion, which can be modeled in small animals. This has significant implications for protein replacement therapy.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Jing Guo, Shuai He, Yongjie Zhu, Wei Yu, Dong Yang, Xudong Zhao
Summary: This study demonstrates that CD30-directed CARs constructed using humanized antibody fragments show comparable efficacy to those using mouse antibodies in vitro and in a mouse model. Humanized CARs have the advantages of reducing immune rejection and improving cell persistence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Kevin Louis, Camila Macedo, Diana Metes
Summary: This review provides a comprehensive summary of the role of T follicular helper cells in humoral alloimmunity, discussing the impact of current therapies on these cells and exploring future directions for biotherapeutic targeting aimed at personalized and precision medicine in treating antibody-mediated rejection.
Article
Medicine, General & Internal
Hongwen Li, Wenting Song, Jiazhuo Wu, Zhuangzhuang Shi, Yuyang Gao, Jiwei Li, Lijuan Han, Jianxiang Zhang, Zhaoming Li, Yong Li, Mingzhi Zhang
Summary: In this study, four CAR-T cell lines were generated to evaluate their effectiveness against NKTCL cells. The results showed that these CAR-T cell lines exhibited significant cytotoxicity against NKTCL cells both in vitro and in vivo, indicating their potential therapeutic promise in treating NKTCL.
Article
Immunology
Edward Sullivan, Sylvie Lecollinet, Adeline Kerviel, Erika Hue, Stephane Pronost, Cecile Beck, Marine Dumarest, Stephan Zientara, Polly Roy
Summary: The study investigated the effectiveness of a combination ECRA vaccine and the duration of immunity triggered by ECRA vaccines in ponies. The first group of ponies developed neutralizing antibody responses against all 9 serotypes without any cross-serotype interference, while the second group developed robust and sustained neutralizing antibody responses against a single serotype.
Article
Cell Biology
Anouk von Borstel, Thi H. O. Nguyen, Louise C. Rowntree, Thomas M. Ashhurst, Lilith F. Allen, Lauren J. Howson, Natasha E. Holmes, Olivia C. Smibert, Jason A. Trubiano, Claire L. Gordon, Allen C. Cheng, Stephen J. Kent, Jamie Rossjohn, Katherine Kedzierska, Martin S. Davey
Summary: SARS-CoV-2 infection can cause severe COVID-19 in some individuals. The immune system, particularly effector gamma delta T cells, plays a role in the defense against SARS-CoV-2. Our study shows an association between effector populations of gamma delta T cells and acute COVID-19 in unvaccinated individuals.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Correction
Immunology
Bruce D. Wines, Liriye Kurtovic, Halina M. Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L. Mordant, Wen Shi Lee, Nicholas A. Gherardin, Sheila K. Patel, Gemma E. Hartley, Phillip Pymm, James P. Cooney, James G. Beeson, Dale I. Godfrey, Louise M. Burrell, Menno C. van Zelm, Adam K. Wheatley, Amy W. W. Chung, Wai-Hong Tham, Kanta Subbarao, Stephen J. Kent, P. Mark Hogarth
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Huijun Liu, Ao Lee, Wenshi Lee, Ping Guo
Summary: This study proposes a dynamic adaptive ACO (DAACO) algorithm to solve the TSP problem. DAACO introduces diversity in the initialization of the ACO algorithm by dynamically determining the number of ants to prevent local optimization. It also adopts a hybrid local selection strategy to improve the quality of optimization and reduce the time required. Experimental results demonstrate that the DAACO algorithm outperforms existing state-of-the-art ACO algorithms in terms of convergence time, solution quality, and average value on the TSPLIB dataset.
COMPLEX & INTELLIGENT SYSTEMS
(2023)
Article
Immunology
Kirsty R. Field, Kathleen M. Wragg, Wen Shi Lee, Marc Rigau, Adam P. Uldrich, Stephen J. Kent, Jennifer A. Juno
Summary: V?9Vd2 T cells can recognize various molecules associated with cellular stress or transformation, providing a unique avenue for the treatment of cancers or infectious diseases. Enhancing the cytotoxic effector function of V?9Vd2 T cells is one potential avenue through which the immunotherapeutic potential of this subset may be improved.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Marios Koutsakos, Arnold Reynaldi, Wen Shi Lee, Julie Nguyen, Thakshila Amarasena, George Taiaroa, Paul Kinsella, Kwee Chin Liew, Thomas Tran, Helen E. Kent, Hyon-Xhi Tan, Louise C. Rowntree, Thi H. O. Nguyen, Paul G. Thomas, Katherine Kedzierska, Jan Petersen, Jamie Rossjohn, Deborah A. Williamson, David Khoury, Miles P. Davenport, Stephen J. Kent, Adam K. Wheatley, Jennifer A. Juno
Summary: By analyzing the cellular immune response in previously vaccinated individuals infected with Delta or Omicron variants of SARS-CoV-2, researchers found that spike-specific CD4+ and CD8+ memory T cells were rapidly activated and contributed to the control of viral replication.
Letter
Virology
Peter Speck, Jason Mackenzie, Rowena A. Bull, Barry Slobedman, Heidi Drummer, Johanna Fraser, Lara Herrero, Karla Helbig, Sarah Londrigan, Gregory Moseley, Natalie Prow, Grant Hansman, Robert Edwards, Chantelle Ahlenstiel, Allison Abendroth, David Tscharke, Jody Hobson-Peters, Robson Kriiger-Loterio, Rhys Parry, Glenn Marsh, Emma Harding, David A. Jacques, Matthew J. Gartner, Wen Shi Lee, Julie McAuley, Paola Vaz, Frank Sainsbury, Michelle D. Tate, Jane Sinclair, Allison Imrie, Stephen Rawlinson, Andrew Harman, Jillian M. Carr, Ebony A. Monson, Merilyn Hibma, Timothy J. Mahony, Thomas Tu, Robert J. Center, Lok Bahadur Shrestha, Robyn Hall, Morgyn Warner, Vernon Ward, Danielle E. Anderson, Nicholas S. Eyre, Natalie E. Netzler, Alison J. Peel, Peter Revill, Michael Beard, Alistair R. Legione, Alexandra J. Spencer, Adi Idris, Jade Forwood, Subir Sarker, Damian F. J. Purcell, Nathan Bartlett, Joshua M. Deerain, Bruce J. Brew, Sassan Asgari, Helen Farrell, Alexander Khromykh, Daniel Enosi Tuipulotu, David Anderson, Sevim Mese, Yaman Tayyar, Kathryn Edenborough, Jasim Muhammad Uddin, Abrar Hussain, Connor J. I. Daymond, Jacinta Agius, Karyn N. Johnson, Paniz Shirmast, Mahdi Abedinzadeshahri, Robin MacDiarmid, Caroline L. Ashley, Jay Laws, Lucy L. Furfaro, Thomas D. Burton, Stephen M. R. Johnson, Zahra Telikani, Mary Petrone, Justin A. Roby, Carolyn Samer, Andreas Suhrbier, April van der Kamp, Anthony Cunningham, Celeste Donato, Jackie Mahar, Wesley D. Black, Subhash Vasudevan, Roman Lenchine, Kirsten Spann, Daniel J. Rawle, Penny Rudd, Jessica Neil, Richard Kingston, Timothy P. Newsome, Ki Wook Kim, Johnson Mak, Kym Lowry, Nathan Bryant, Joanne Meers, Jason A. Roberts, Nigel McMillan, Larisa I. Labzin, Andrii Slonchak, Leon E. Hugo, Bennett Henzeler, Natalee D. Newton, Cassandra T. David, Patrick C. Reading, Camille Esneau, Tatiana Briody, Najla Nasr, Donna McNeale, Brian McSharry, Omid Fakhri, Bethany A. Horsburgh, Grant Logan, Paul Howley, Paul Young
JOURNAL OF VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
David S. Khoury, Steffen S. Docken, Kanta Subbarao, Stephen J. Kent, Miles P. Davenport, Deborah Cromer
Summary: Booster vaccination is necessary to combat waning immunity and variants of SARS-CoV-2. Data on neutralization titers from multiple sources suggest that using ancestral vaccines can enhance protection against symptomatic and severe disease caused by variant viruses. Variant-modified vaccines may provide additional benefits. This study provides evidence-based guidance for future COVID-19 vaccine regimens.
Article
Multidisciplinary Sciences
Deborah Cromer, Megan Steain, Arnold Reynaldi, Timothy E. Schlub, Shanchita R. Khan, Sarah C. Sasson, Stephen J. Kent, David S. Khoury, Miles P. Davenport
Summary: The study demonstrates a strong correlation between neutralising antibody titres and vaccine effectiveness against symptomatic and severe COVID-19. Predicted neutralising antibody titres are strongly correlated with observed vaccine effectiveness, and the loss of neutralising antibodies over time and to new variants is predictive of observed vaccine protection against severe COVID-19.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Mai N. Vu, Emily H. Pilkington, Wen Shi Lee, Hyon-Xhi Tan, Thomas P. Davis, Nghia P. Truong, Stephen J. Kent, Adam K. Wheatley
Summary: Using monoclonal antibodies to target vaccine antigens to specific immune cells within lymph nodes can enhance immune responses. The authors developed a system using self-assembling ferritin nanoparticles to attach antibodies to the nanoparticles, allowing for rapid screening of different targeting antibodies. By targeting Clec9a, the authors observed higher antibody titers and increased germinal center formation, leading to robust antibody responses. However, the effectiveness of immune cell targeting depends on the antigen, with variation observed for different immunogens.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Medicine, General & Internal
Georgia Deliyannis, Nicholas A. Gherardin, Chinn Yi Wong, Samantha L. Grimley, James P. Cooney, Samuel J. Redmond, Paula Ellenberg, Kathryn C. Davidson, Francesca L. Mordant, Tim Smith, Marianne Gillard, Ester Lopez, Julie McAuley, Chee Wah Tan, Jing J. Wang, Weiguang Zeng, Mason Littlejohn, Runhong Zhou, Jasper Fuk-Woo Chan, Zhi-wei Chen, Airn E. Hartwig, Richard Bowen, Jason M. Mackenzie, Elizabeth Vincan, Joseph Torresi, Katherine Kedzierska, Colin W. Pouton, Tom P. Gordon, Lin-fa Wang, Stephen J. Kent, Adam K. Wheatley, Sharon R. Lewin, Kanta Subbarao, Amy W. Chung, Marc Pellegrini, Trent Munro, Terry Nolan, Steven Rockman, David C. Jackson, Damian F. J. Purcell, Dale I. Godfrey
Summary: Researchers have developed a protein subunit vaccine to address the variants of the SARS-CoV-2 virus. The vaccine induces strong neutralizing antibody responses and provides durable immunity against upper and lower airway infections. It has the potential to complement existing vaccines and is currently in a phase I clinical trial.
Article
Multidisciplinary Sciences
Eva Stadler, Martin T. Burgess, Timothy E. Schlub, Shanchita R. Khan, Khai Li Chai, Zoe K. McQuilten, Erica M. Wood, Mark N. Polizzotto, Stephen J. Kent, Deborah Cromer, Miles P. Davenport, David S. Khoury
Summary: Multiple monoclonal antibodies have been effective for both prophylaxis and therapy for SARS-CoV-2 infection. This study aggregates data from randomized controlled trials to model the dose-response relationship of monoclonal antibodies for prophylaxis. The estimated 50% protection from COVID-19 is achieved with a concentration of 96-fold of the in vitro IC50.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
David S. Khoury, Timothy E. Schlub, Deborah Cromer, Megan Steain, Youyi Fong, Peter B. Gilbert, Kanta Subbarao, James A. Triccas, Stephen J. Kent, Miles P. Davenport
Summary: Multiple studies have demonstrated a correlation between neutralizing antibody levels and protection from COVID-19, estimating the relationship between the two. However, estimates of the required level of neutralizing antibodies for protection vary across these studies. By normalizing antibody titers, it has been found that there is a consistent relationship between antibody levels and protection from COVID-19. This finding is crucial for future vaccine planning, assessing population immunity, and mitigating the global impact of the COVID-19 pandemic.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Immunology
Ebene R. Haycroft, Timon Damelang, Ester Lopez, Mark A. Rodgers, Bruce D. Wines, Mark Hogarth, Cassaundra L. Ameel, Stephen J. Kent, Charles A. Scanga, Shelby L. O'Connor, Amy W. Chung
Summary: This study used a macaque model of tuberculosis and HIV co-infection to investigate the humoral responses. They found that antibody responses to tuberculosis were impaired during HIV co-infection. The study suggests that humoral immunity and antibody glycosylation may play a role in the control and progression of tuberculosis.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2023)