Novel Mode of ISG15-Mediated Protection against Influenza A Virus and Sendai Virus in Mice

Cellular Inhibitor of Apoptosis Protein cIAP2 Protects against Pulmonary Tissue Necrosis during Influenza Virus Infection to Promote Host Survival

(2014) Ian Gaël Rodrigue-Gervais et al.   Cell Host & Microbe

Pathogenic potential of interferon αβ in acute influenza infection

(2014) Sophia Davidson et al.   Nature Communications

A Systems Analysis Identifies a Feedforward Inflammatory Circuit Leading to Lethal Influenza Infection

(2013) Marlène Brandes et al.   CELL

ISG15 Regulates Peritoneal Macrophages Functionality against Viral Infection

(2013) Emilio Yángüez et al.   PLoS Pathogens

Immunopathology in influenza virus infection: Uncoupling the friend from foe

(2012) Daniela Damjanovic et al.   CLINICAL IMMUNOLOGY

HERC6 Is the Main E3 Ligase for Global ISG15 Conjugation in Mouse Cells

(2012) Diede Oudshoorn et al.   PLoS One

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

Mycobacterial Disease and Impaired IFN-  Immunity in Humans with Inherited ISG15 Deficiency

(2012) D. Bogunovic et al.   SCIENCE

mHERC6 is the essential ISG15 E3 ligase in the murine system

(2011) Lars Ketscher et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells

(2011) Shyamal D Desai et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag

(2011) Matthew W Woods et al.   Retrovirology

Interferon-stimulated genes and their antiviral effector functions

(2011) John W Schoggins et al.   Current Opinion in Virology

ISG15 Is Critical in the Control of Chikungunya Virus Infection Independent of UbE1L Mediated Conjugation

(2011) Scott W. Werneke et al.   PLoS Pathogens

Type I Interferon Signaling Regulates Ly6Chi Monocytes and Neutrophils during Acute Viral Pneumonia in Mice

(2011) Sang-Uk Seo et al.   PLoS Pathogens

Species Specificity of the NS1 Protein of Influenza B Virus

(2010) Haripriya Sridharan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Herc5 Attenuates Influenza A Virus by Catalyzing ISGylation of Viral NS1 Protein

(2010) Y. Tang et al.   JOURNAL OF IMMUNOLOGY

Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification

(2010) H. X. Shi et al.   MOLECULAR AND CELLULAR BIOLOGY

The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15

(2010) Larissa A. Durfee et al.   MOLECULAR CELL

ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells

(2010) C. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway

(2009) Young Joo Jeon et al.   EMBO REPORTS

Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice

(2009) Arash Shahangian et al.   JOURNAL OF CLINICAL INVESTIGATION

Interferon-Induced ISG15 Conjugation Inhibits Influenza A Virus Gene Expression and Replication in Human Cells

(2009) T.-Y. Hsiang et al.   JOURNAL OF VIROLOGY

ISG15 Inhibits Nedd4 Ubiquitin E3 Activity and Enhances the Innate Antiviral Response

(2008) Oxana A. Malakhova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice Lacking the ISG15 E1 Enzyme UbE1L Demonstrate Increased Susceptibility to both Mouse-Adapted and Non-Mouse-Adapted Influenza B Virus Infection

(2008) C. Lai et al.   JOURNAL OF VIROLOGY

ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity

(2008) A. Okumura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccinia Virus E3 Protein Prevents the Antiviral Action of ISG15

(2008) Susana Guerra et al.   PLoS Pathogens

H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

(2008) Lucy A. Perrone et al.   PLoS Pathogens