Cholesterol-Dependent Membrane Fusion Induced by the gp41 Membrane-Proximal External Region-Transmembrane Domain Connection Suggests a Mechanism for Broad HIV-1 Neutralization

The three lives of viral fusion peptides

(2014) Beatriz Apellániz et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Disruption of Helix-Capping Residues 671 and 674 Reveals a Role in HIV-1 Entry for a Specialized Hinge Segment of the Membrane Proximal External Region of gp41

(2013) Zhen-Yu J. Sun et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Characterization of Cleaved, Soluble HIV-1 Envelope Glycoprotein Trimers

(2013) R. Khayat et al.   JOURNAL OF VIROLOGY

Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein

(2013) P. J. Klasse et al.   JOURNAL OF VIROLOGY

Mechanism of HIV-1 Neutralization by Antibodies Targeting a Membrane-Proximal Region of gp41

(2013) J. Chen et al.   JOURNAL OF VIROLOGY

Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy

(2013) Alberto Bartesaghi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

(2013) J.-P. Julien et al.   SCIENCE

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

(2013) D. Lyumkis et al.   SCIENCE

Antibodies in HIV-1 Vaccine Development and Therapy

(2013) F. Klein et al.   SCIENCE

HIV entry: a game of hide-and-fuse?

(2013) Gregory B Melikyan   Current Opinion in Virology

Lipid Tail Protrusion in Simulations Predicts Fusogenic Activity of Influenza Fusion Peptide Mutants and Conformational Models

(2013) Per Larsson et al.   PLoS Computational Biology

Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10

(2013) Kathryn A. K. Finton et al.   PLoS Pathogens

Mechanism of membrane perturbation by the HIV-1 gp41 membrane-proximal external region and its modulation by cholesterol

(2012) Andrey Ivankin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies

(2012) Peter D. Kwong et al.   IMMUNITY

HIV Entry and Envelope Glycoprotein-mediated Fusion

(2012) Robert Blumenthal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

(2012) Jinghe Huang et al.   NATURE

Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion

(2011) Michelle de la Vega et al.   Retrovirology

All-Atom Models of the Membrane-Spanning Domain of HIV-1 gp41 from Metadynamics

(2010) Vamshi K. Gangupomu et al.   BIOPHYSICAL JOURNAL

Cooperative elastic stresses, the hydrophobic effect, and lipid tilt in membrane remodeling

(2010) Vadim A. Frolov et al.   FEBS LETTERS

Ablation of the Complementarity-Determining Region H3 Apex of the Anti-HIV-1 Broadly Neutralizing Antibody 2F5 Abrogates Neutralizing Capacity without Affecting Core Epitope Binding

(2010) J. P. Julien et al.   JOURNAL OF VIROLOGY

Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions

(2010) E. M. Scherer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein-driven membrane stresses in fusion and fission

(2010) Michael M. Kozlov et al.   TRENDS IN BIOCHEMICAL SCIENCES

HIV-1 gp41 and TCRα Trans-Membrane Domains Share a Motif Exploited by the HIV Virus to Modulate T-Cell Proliferation

(2010) Tomer Cohen et al.   PLoS Pathogens

Crystal Structure of HIV-1 gp41 Including Both Fusion Peptide and Membrane Proximal External Regions

(2010) Victor Buzon et al.   PLoS Pathogens

4E10 and 2F5 monoclonal antibodies: binding specificities to phospholipids, tolerance, and clinical safety issues

(2009) Carl R Alving   AIDS

Distinct Mechanisms of Lipid Bilayer Perturbation Induced by Peptides Derived from the Membrane-Proximal External Region of HIV-1 gp41

(2009) Beatriz Apellániz et al.   BIOCHEMISTRY

HIV Enters Cells via Endocytosis and Dynamin-Dependent Fusion with Endosomes

(2009) Kosuke Miyauchi et al.   CELL

Role of HIV membrane in neutralization by two broadly neutralizing antibodies

(2009) S. M. Alam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interfacial pre-transmembrane domains in viral proteins promoting membrane fusion and fission

(2008) Maier Lorizate et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

HIV-1 Broadly Neutralizing Antibody Extracts Its Epitope from a Kinked gp41 Ectodomain Region on the Viral Membrane

(2008) Zhen-Yu J. Sun et al.   IMMUNITY

Retroviruses Human Immunodeficiency Virus and Murine Leukemia Virus Are Enriched in Phosphoinositides

(2008) R. Chan et al.   JOURNAL OF VIROLOGY

The Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 4E10 Monoclonal Antibody Is Better Adapted to Membrane-Bound Epitope Recognition and Blocking than 2F5

(2008) N. Huarte et al.   JOURNAL OF VIROLOGY

Importance of the Membrane-Perturbing Properties of the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 gp41 to Viral Fusion

(2008) S. A. Vishwanathan et al.   JOURNAL OF VIROLOGY

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm

(2008) Gregory B Melikyan   Retrovirology

Hydrophobic Substitutions in the First Residue of the CRAC Segment of the gp41 Protein of HIV†

(2007) Sundaram A. Vishwanathan et al.   BIOCHEMISTRY