Journal
JOURNAL OF VIROLOGY
Volume 88, Issue 11, Pages 6524-6527Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00251-14
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Funding
- Juvenile Diabetes Research Foundation [17-2011-519]
- [AI090084]
- [AI082418]
- [T32 AI 007090]
- [P30 DK42086]
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Commensal microbes are often required to control viral infection by facilitating host immune defenses. However, we found that this does not hold true for retroviral infection. We report that retrovirus-resistant mice control the pathogen with virus-neutralizing antibodies independently of commensal microbiota. This is in contrast to orthomyxoviruses and arenaviruses, where resistance is ablated in animals depleted of microbiota. Clearly, when it comes to antiviral immunity, the role of the microbiota cannot be generalized.
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