Article
Agriculture, Dairy & Animal Science
Xin-Yan Yao, Jia-Chun Yang, Sheng Yuan, Fan-Cong Zeng, Yu-Qian Zhang, Hong Liu, Jing Sun, Zhi-Hang Lv, Shu-Jian Huang, Xue-Lian Zhang
Summary: This study identified genetically diversified goose circoviruses (GoCVs) in domesticated geese from Guangdong province, China. Recombination was found to be the primary driver for GoCV diversification, and purifying selection acted as the dominant evolutionary pressure. These findings expand our understanding of the genetic diversity and evolution of GoCVs, and reveal the co-circulation of genetically divergent GoCV strains in certain areas of Guangdong province.
Article
Veterinary Sciences
Fang Yu, Liqiang Liu, Xiaoxiao Tian, Ligong Chen, Xinyi Huang, Yue Sun, Yi Yan, Zhijun Tian, Xuehui Cai, Di Liu, Tongqing An
Summary: This study aimed to analyze the genetic diversity, recombination, and evolution of porcine reproductive and respiratory syndrome virus 1 in China from 1991 to 2018. The results showed that high-frequency recombination regions were concentrated in non-structural protein 2 and structural proteins 2 to 4, with extensive deletions in non-structural protein 2. Phylogenetic analysis revealed four independent introductions in China. It is recommended to strengthen prevention and control measures for porcine reproductive and respiratory syndrome virus 1 to prevent further spread.
VETERINARY SCIENCES
(2022)
Article
Ecology
Colin Olito, Suvi Ponnikas, Bengt Hansson, Jessica K. Abbott
Summary: The evolution of suppressed recombination between sex chromosomes is influenced by beneficial mutations, with small inversions eventually becoming harmful. Factors such as inversion size, mutation rate, and the dominance coefficient of deleterious mutations play a key role in the evolutionary process. The results suggest that deleterious genetic variation can drive recombination suppression in small steps.
Article
Behavioral Sciences
Scott Mishler, Jing Chen
Summary: This study investigated countermeasures to the vigilance decrement during a simulated partially automated driving task. The results showed that a driving-related secondary task can alleviate the vigilance decrement, while a non-driving related secondary task cannot.
Article
Clinical Neurology
Ariane Zamarioli, Mariana M. Butezloff, Joao P. B. Ximenez, Jose B. Volpon
Summary: Low-intensity pulsed ultrasound (LIPUS) has positive effects on the quality of femoral fracture callus formation in rats with severe osteoporosis secondary to spinal cord injury (SCI), by promoting bone formation, decreasing bone resorption, and improving microarchitecture.
Article
Clinical Neurology
Christina Mayer, Marcel S. Woo, Thomas Theo Brehm, Andreas Heyer, Marlene Fischer, Felix Fischbach, Lukas C. Bal, Marylyn M. Addo, Stefan Kluge, Goetz Thomalla, Nils Schweingruber, Julian Schulze zur Wiesch
Summary: This study aimed to investigate whether pre-existing neurological conditions, such as dementia and a history of cerebrovascular disease, increase the risk of severe outcomes in patients hospitalized with SARS-CoV-2 infection in 2022. The analysis revealed that pre-existing cerebrovascular disease and all-cause dementia did not increase the risk of mortality or ICU admission. However, patients with pre-existing cerebrovascular disease and myocardial infarction in their medical history may be more susceptible to vascular complications following SARS-CoV-2 infection with the Omicron variant.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Fumika Azuma, Kazuya Nokura, Tetsuharu Kako, Mari Yoshida, Shinsui Tatsumi
Summary: This case report presents a 57-year-old woman with optic neuritis and repeated focal demyelination of the cerebral white matter and brain stem for 14 years. The clinical symptoms mimicked secondary progressive multiple sclerosis, but the exact cause was unclear. Histopathological findings indicated the etiology to be neuromyelitis optica spectrum disorders (NMOSD), with no apparent plaque in spinal cord specimens. Therefore, an accurate clinical diagnosis requires serum anti-aquaporin 4 antibody measurements as well as an autopsy examination.
Article
Infectious Diseases
Temitope O. C. Faleye, Amir Elyaderani, Peter Skidmore, Sangeet Adhikari, Abriana Smith, Nicole Kaiser, Helen Sandrolini, Sarah Finnerty, Rolf U. Halden, Arvind Varsani, Matthew Scotch
Summary: We investigated the presence and diversity of rhinoviruses in nasopharyngeal swab samples from 248 individuals with influenza-like illness (ILI). We identified at least 13 rhinovirus genotypes and 16 variants that contributed to the burden of ILI in the community. Additionally, we described the complete capsid protein gene of an unassigned rhinovirus A genotype (AZ88**).
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2023)
Article
Virology
Elise N. Paietta, Simona Kraberger, Joy M. Custer, Karla L. Vargas, Koenraad Van Doorslaer, Anne D. Yoder, Arvind Varsani
Summary: This study identifies three oral papillomaviruses in critically endangered black-and-white ruffed lemurs, including two highly similar viruses named Varecia variegata papillomavirus 1 (VavPV1) and a less similar one named Varecia variegata papillomavirus 2 (VavPV2). The discovery of these viruses suggests the presence of diverse papillomaviruses across lemurs.
ARCHIVES OF VIROLOGY
(2023)
Article
Virology
Gabriella M. Cerna, Laurel E. K. Serieys, Seth P. D. Riley, Cecile Richet, Simona Kraberger, Arvind Varsani
Summary: Viruses belonging to the family Circoviridae were discovered in bobcats in California, with one new species identified. It is unclear whether these viruses infect bobcats, their prey, or their gut parasites.
ARCHIVES OF VIROLOGY
(2023)
Article
Virology
Simona Kraberger, Laurel E. K. Serieys, Seth P. D. Riley, Kara Schmidlin, Eric S. Newkirk, John R. Squires, Christopher B. Buck, Arvind Varsani
Summary: By analyzing fecal samples from bobcats, pumas, Canada lynxes, and grizzly bears in the USA, we identified six novel polyomavirus genomes. These viruses showed a phylogenetic relationship to polyomaviruses found in prey animals, suggesting carnivores may become infected with polyomaviruses through predation. Furthermore, we found anelloviruses known to infect pigs in the grizzly bear sample, indicating the bear may have preyed on a wild or domestic pig.
ARCHIVES OF VIROLOGY
(2023)
Article
Virology
Andreza H. Vidal, Cristiano Lacorte, Marcio M. Sanches, Dione M. T. Alves-Freitas, Emanuel F. M. Abreu, Bruna Pinheiro-Lima, Raul C. Carriello Rosa, Onildo N. Jesus, Magnolia A. Campos, Gustavo P. Felix, Ana Clara R. Abreu, Yam S. Santos, Ana Luiza M. Lacerda, Arvind Varsani, Fernando L. Melo, Simone G. Ribeiro
Summary: High-throughput sequencing (HTS) is an important tool for discovering and monitoring plant viruses. In passion fruit (PF) plants in Bahia state, Brazil, co-infections of cucurbit aphid-borne yellows virus (CABYV) and cowpea aphid-borne mosaic virus (CABMV) were identified using HTS technology, bioinformatics tools, RT-PCR, and Sanger sequencing. Phylogenetic analysis showed CABYV-PF to be closely related to French and Spanish isolates, and the complete genomes suggested the presence of ten distinct CABYV species, including Polerovirus curcubitaeprimum and Polerovirus melo.
Article
Microbiology
Jasmine K. M. Lopez, Charlotte Austin, Kata Farkas, Simona Kraberger, William Davison, Arvind Varsani
Summary: Sharp-spined notothen (Trematomus pennellii) is an icefish endemic to the southern ocean. From the stomach of an individual, we identified the genomes of 51 microviruses (family Microviridae). The major capsid proteins of most of these share the closest similarities to those identified in other marine organisms.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Microbiology
Ainsley R. Chapman, Jillian M. Wright, Nicole A. Kaiser, Peter M. Jones, Erin M. Driver, Rolf U. Halden, Arvind Varsani, Matthew Scotch, Temitope O. C. Faleye
Summary: This paper describes the genome of MAZ-Nov-2020, a microvirus identified from municipal wastewater in Maricopa County, Arizona, USA, in November 2020. The genome is 4,696 nucleotides long, with a GC content of 56% and a coverage of 3,641x. It encodes major capsid protein, endolysin, replication initiator protein, and two hypothetical proteins, one of which is predicted to be a membrane-associated multiheme cytochrome c.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Virology
Arvind Varsani, Simona Kraberger, Tanja Opriessnig, Fabrizio Maggi, Vladimir Celer, Hiroaki Okamoto, Philippe Biagini
Summary: The Anelloviridae family consists of negative single-stranded circular DNA viruses. Among them, anelloviruses in the Gyrovirus genus are found infecting avian species, while those in the other 29 genera primarily infect mammal species. The 146 anellovirus species have been renamed according to the guidelines set by the International Committee on Taxonomy of Viruses (ICTV).
ARCHIVES OF VIROLOGY
(2023)
Article
Virology
Karla L. Vargas, Simona Kraberger, Joy M. Custer, Elise N. Paietta, Melanie Culver, Adrian Munguia-Vega, Greer A. Dolby, Arvind Varsani
Summary: This study utilized viral metagenomics to identify a novel polyomavirus in fecal samples from wild rodents in the Baja California peninsula, Mexico. The discovery expands our understanding of rodent viral ecology and evolution.
ARCHIVES OF VIROLOGY
(2023)
Correction
Virology
Francisco Murilo Zerbini, Stuart G. Siddell, Elliot J. Lefkowitz, Arcady R. Mushegian, Evelien M. Adriaenssens, Poliane Alfenas-Zerbini, Donald M. Dempsey, Bas E. Dutilh, Maria Laura Garcia, R. Curtis Hendrickson, Sandra Junglen, Mart Krupovic, Jens H. Kuhn, Amy J. Lambert, Malgorzata Lobocka, Hanna M. Oksanen, David L. Robertson, Luisa Rubino, Sead Sabanadzovic, Peter Simmonds, Donald B. Smith, Nobuhiro Suzuki, Koenraad Van Doorslaer, Anne-Mieke Vandamme, Arvind Varsani
ARCHIVES OF VIROLOGY
(2023)
Letter
Biotechnology & Applied Microbiology
Evelien M. M. Adriaenssens, Simon Roux, J. Rodney Brister, Ilene Karsch-Mizrachi, Jens H. H. Kuhn, Arvind Varsani, Tong Yigang, Alejandro Reyes, Cedric Lood, Elliot J. J. Lefkowitz, Matthew B. B. Sullivan, Robert A. A. Edwards, Peter Simmonds, Luisa Rubino, Sead Sabanadzovic, Mart Krupovic, Bas E. E. Dutilh
NATURE BIOTECHNOLOGY
(2023)
Correction
Biotechnology & Applied Microbiology
Evelien M. M. Adriaenssens, Simon Roux, J. Rodney Brister, Ilene Karsch-Mizrachi, Jens H. Kuhn, Arvind Varsani, Tong Yigang, Alejandro Reyes, Cedric Lood, Elliot J. Lefkowitz, Matthew B. B. Sullivan, Robert A. A. Edwards, Peter Simmonds, Luisa Rubino, Sead Sabanadzovic, Mart Krupovic, Bas E. E. Dutilh
NATURE BIOTECHNOLOGY
(2023)
Article
Infectious Diseases
Temitope O. C. Faleye, Erin M. Driver, Devin A. Bowes, Abriana Smith, Nicole A. Kaiser, Jillian M. Wright, Ainsley R. Chapman, Rolf U. Halden, Arvind Varsani, Matthew Scotch
Summary: In this study, CPV genomes were sequenced from dog feces collected in poop bags, and a variant of CPV-2c with amino acid substitutions in NS1 and NS2 was identified in Arizona, USA in June 2022. This genome is the only CPV genome described in the USA from the 2022 season, despite reports of CPV outbreaks and fatalities in dogs. Further studies and experimental research are needed to enhance our understanding of the evolutionary process of CPV.
TRANSBOUNDARY AND EMERGING DISEASES
(2023)
Article
Virology
Elise N. Paietta, Simona Kraberger, Joy M. Custer, Karla L. Vargas, Claudia Espy, Erin Ehmke, Anne D. Yoder, Arvind Varsani
Summary: This study utilized metagenomic sequencing methods to explore the diversity of oral viruses in humans. The samples were collected from healthy individuals and various viruses, including coronaviruses, bacteriophages, and inoviruses, were identified. These findings expand our understanding of the diversity of oral viruses in North Carolina, USA.
Article
Virology
Sohini Claverie, Murielle Hoareau, Selim Ben Chehida, Denis Filloux, Arvind Varsani, Philippe Roumagnac, Darren P. Martin, Jean-Michel Lett, Pierre Lefeuvre
Summary: As highly pervasive parasites, viruses are likely major components of all natural ecosystems. We focused on understanding the ecological roles of viruses by studying Mastrevirus genus, which infects uncultivated grasses throughout tropical and sub-tropical regions. Our findings reveal the host preferences and diverse distribution of Mastrevirus, suggesting the importance of perennial plant species in generating viral recombinants.