The Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Induced 5-Lipoxygenase-Leukotriene B4 Cascade Plays Key Roles in KSHV Latency, Monocyte Recruitment, and Lipogenesis

A Mutant of Hepatitis B Virus X Protein (HBxΔ127) Promotes Cell Growth through A Positive Feedback Loop Involving 5-Lipoxygenase and Fatty Acid Synthase

(2015) Qi Wang et al.   NEOPLASIA

Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells

(2013) Xiaona You et al.   CARCINOGENESIS

Concurrent targeting of eicosanoid receptor 1/eicosanoid receptor 4 receptors and COX-2 induces synergistic apoptosis in Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus associated non-Hodgkin lymphoma cell lines

(2013) Arun George Paul et al.   Translational Research

Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-κB in hepatoma cells

(2012) Yu Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Leukotriene B4 inhibits neutrophil apoptosis via NADPH oxidase activity: Redox control of NF-κB pathway and mitochondrial stability

(2012) Pedro Barcellos-de-Souza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Reactive Oxygen Species Are Induced by Kaposi's Sarcoma-Associated Herpesvirus Early during Primary Infection of Endothelial Cells To Promote Virus Entry

(2012) Virginie Bottero et al.   JOURNAL OF VIROLOGY

Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma

(2012) A. P. Bhatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Metabolic Profiling of Infection by an Oncogenic Virus: KSHV Induces and Requires Lipogenesis for Survival of Latent Infection

(2012) Tracie Delgado et al.   PLoS Pathogens

A novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN sustains high growth of breast cancer cells

(2011) Nan Hu et al.   ACTA PHARMACOLOGICA SINICA

The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemia

(2011) Yaoyu Chen et al.   CELL CYCLE

Targeting KSHV/HHV-8 Latency with COX-2 Selective Inhibitor Nimesulide: A Potential Chemotherapeutic Modality for Primary Effusion Lymphoma

(2011) Arun George Paul et al.   PLoS One

A mutant of HBx (HBxΔ127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase

(2010) Qi Wang et al.   ACTA PHARMACOLOGICA SINICA

Circulating Endothelial Progenitor Cells, Th1/Th2/Th17-Related Cytokines, and Endothelial Dysfunction in Resistant Hypertension

(2010) Eli Magen et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Piracy of Prostaglandin E2/EP Receptor–Mediated Signaling by Kaposi's Sarcoma-Associated Herpes Virus (HHV-8) for Latency Gene Expression: Strategy of a Successful Pathogen

(2010) Arun George Paul et al.   CANCER RESEARCH

Leukotriene B4Is a Physiologically Relevant Endogenous Peroxisome Proliferator-activated Receptor-α Agonist

(2010) Venkata R. Narala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kaposi's Sarcoma-Associated Herpesvirus K3 and K5 Proteins Block Distinct Steps in Transendothelial Migration of Effector Memory CD4+ T Cells by Targeting Different Endothelial Proteins

(2010) T. D. Manes et al.   JOURNAL OF IMMUNOLOGY

NFAT and CREB Regulate Kaposi's Sarcoma-Associated Herpesvirus-Induced Cyclooxygenase 2 (COX-2)

(2010) N. Sharma-Walia et al.   JOURNAL OF VIROLOGY

Inflammatory lipid mediators in adipocyte function and obesity

(2010) Abishek Iyer et al.   Nature Reviews Endocrinology

Nucleophosmin Phosphorylation by v-Cyclin-CDK6 Controls KSHV Latency

(2010) Grzegorz Sarek et al.   PLoS Pathogens

Kaposi's Sarcoma Associated Herpes Virus (KSHV) Induced COX-2: A Key Factor in Latency, Inflammation, Angiogenesis, Cell Survival and Invasion

(2010) Neelam Sharma-Walia et al.   PLoS Pathogens

Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis

(2009) Christos C. Zouboulis et al.   EXPERIMENTAL DERMATOLOGY

The plasma lipidomic signature of nonalcoholic steatohepatitis

(2009) Puneet Puri et al.   HEPATOLOGY

Early Events in Kaposi's Sarcoma-Associated Herpesvirus Infection of Target Cells

(2009) B. Chandran   JOURNAL OF VIROLOGY

Reactive oxygen species and lipoxygenases regulate the oncogenicity of NPM-ALK-positive anaplastic large cell lymphomas

(2009) K Thornber et al.   ONCOGENE

Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus

(2009) Cristina Aresté et al.   TRENDS IN MICROBIOLOGY

HIV-associated lymphomas and gamma-herpesviruses

(2008) A. Carbone et al.   BLOOD

Leukotriene B4 enhances the activity of nuclear factor- B pathway through BLT1 and BLT2 receptors in atherosclerosis

(2008) E. Sanchez-Galan et al.   CARDIOVASCULAR RESEARCH

Kaposi's Sarcoma Herpes Virus Taps into a Host MicroRNA Regulatory Network

(2008) Lydia V. McClure et al.   Cell Host & Microbe

Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo

(2008) Hans-Erik Claesson et al.   FEBS Journal

Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice

(2008) Marta López-Parra et al.   JOURNAL OF LIPID RESEARCH

On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma

(2008) Hans-Erik Claesson   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis

(2008) Chengyu Liang et al.   SEMINARS IN CANCER BIOLOGY

The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma

(2008) L Feller et al.   AIDS Research and Therapy