Isolate-Specific Differences in the Conformational Dynamics and Antigenicity of HIV-1 gp120

HIV-1 envelope glycoprotein structure

(2013) Alan Merk et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

(2013) Hua-Xin Liao et al.   IMMUNITY

Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG

(2013) G. D. Tomaras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purification of recombinant vaccinia virus-expressed monomeric HIV-1 gp120 to apparent homogeneity

(2013) Wenjin Guo et al.   PROTEIN EXPRESSION AND PURIFICATION

A Mechanistic Understanding of Allosteric Immune Escape Pathways in the HIV-1 Envelope Glycoprotein

(2013) Anurag Sethi et al.   PLoS Computational Biology

Allosteric Modulation of the HIV-1 gp120-gp41 Association Site by Adjacent gp120 Variable Region 1 (V1) N-Glycans Linked to Neutralization Sensitivity

(2013) Heidi E. Drummer et al.   PLoS Pathogens

The Highly Conserved Layer-3 Component of the HIV-1 gp120 Inner Domain Is Critical for CD4-Required Conformational Transitions

(2012) A. Desormeaux et al.   JOURNAL OF VIROLOGY

Antigenicity and Immunogenicity of RV144 Vaccine AIDSVAX Clade E Envelope Immunogen Is Enhanced by a gp120 N-Terminal Deletion

(2012) S. Munir Alam et al.   JOURNAL OF VIROLOGY

Solution Structure, Conformational Dynamics, and CD4-Induced Activation in Full-Length, Glycosylated, Monomeric HIV gp120

(2012) Miklos Guttman et al.   JOURNAL OF VIROLOGY

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

(2012) Barton F. Haynes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural Plasticity and Conformational Transitions of HIV Envelope Glycoprotein gp120

(2012) Anil Korkut et al.   PLoS One

Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding

(2012) Y. Guan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

(2012) Y. D. Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tracking Hydrogen/Deuterium Exchange at Glycan Sites in Glycoproteins by Mass Spectrometry

(2011) M. Guttman et al.   ANALYTICAL CHEMISTRY

Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law

(2011) Robert P. Rambo et al.   BIOPOLYMERS

An HIV-1 gp120 Envelope Human Monoclonal Antibody That Recognizes a C1 Conformational Epitope Mediates Potent Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity and Defines a Common ADCC Epitope in Human HIV-1 Serum

(2011) G. Ferrari et al.   JOURNAL OF VIROLOGY

Mechanism of Neutralization by the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01

(2011) Y. Li et al.   JOURNAL OF VIROLOGY

Bridging the solution divide: comprehensive structural analyses of dynamic RNA, DNA, and protein assemblies by small-angle X-ray scattering

(2010) Robert P Rambo et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

False EX1 signatures caused by sample carryover during HX MS analyses

(2010) Jing Fang et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Expression-System-Dependent Modulation of HIV-1 Envelope Glycoprotein Antigenicity and Immunogenicity

(2010) Leopold Kong et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural characterization of proteins and complexes using small-angle X-ray solution scattering

(2010) Haydyn D.T. Mertens et al.   JOURNAL OF STRUCTURAL BIOLOGY

Local Conformational Stability of HIV-1 gp120 in Unliganded and CD4-Bound States as Defined by Amide Hydrogen/Deuterium Exchange

(2010) L. Kong et al.   JOURNAL OF VIROLOGY

Topological Layers in the HIV-1 gp120 Inner Domain Regulate gp41 Interaction and CD4-Triggered Conformational Transitions

(2010) Andrés Finzi et al.   MOLECULAR CELL

Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity

(2010) Ron Diskin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comparative Immunogenicity of HIV-1 Clade C Envelope Proteins for Prime/Boost Studies

(2010) Douglas H. Smith et al.   PLoS One

R5 Clade C SHIV Strains with Tier 1 or 2 Neutralization Sensitivity: Tools to Dissect Env Evolution and to Develop AIDS Vaccines in Primate Models

(2010) Nagadenahalli B. Siddappa et al.   PLoS One

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

(2010) T. Zhou et al.   SCIENCE

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

Temporal analysis of HIV envelope sequence evolution and antibody escape in a subtype A-infected individual with a broad neutralizing antibody response

(2010) Katherine A. Bosch et al.   VIROLOGY

Functional properties of the HIV-1 subtype C envelope glycoprotein associated with mother-to-child transmission

(2010) Hong Zhang et al.   VIROLOGY

Molecular Architectures of Trimeric SIV and HIV-1 Envelope Glycoproteins on Intact Viruses: Strain-Dependent Variation in Quaternary Structure

(2010) Tommi A. White et al.   PLoS Pathogens

Toward an Antibody-Based HIV-1 Vaccine

(2009) James A. Hoxie   Annual Review of Medicine

Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Assessment of Neutralizing Antibodies

(2009) M. S. Seaman et al.   JOURNAL OF VIROLOGY

Transitions to and from the CD4-Bound Conformation Are Modulated by a Single-Residue Change in the Human Immunodeficiency Virus Type 1 gp120 Inner Domain

(2009) A. Kassa et al.   JOURNAL OF VIROLOGY

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

(2009) M. Pancera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

(2009) L. Chen et al.   SCIENCE

Immunogenicity of HIV-1 envelope glycoprotein oligomers

(2009) Mattias NE Forsell et al.   Current Opinion in HIV and AIDS

Structure-Based Stabilization of HIV-1 gp120 Enhances Humoral Immune Responses to the Induced Co-Receptor Binding Site

(2009) Barna Dey et al.   PLoS Pathogens

Soluble CD4 and CD4-Mimetic Compounds Inhibit HIV-1 Infection by Induction of a Short-Lived Activated State

(2009) Hillel Haim et al.   PLoS Pathogens

Autologous Neutralizing Humoral Immunity and Evolution of the Viral Envelope in the Course of Subtype B Human Immunodeficiency Virus Type 1 Infection

(2008) E. M. Bunnik et al.   JOURNAL OF VIROLOGY

Specificity of immobilized porcine pepsin in H/D exchange compatible conditions

(2008) Yoshitomo Hamuro et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY