Article
Biochemistry & Molecular Biology
Kristin M. Barry, Donald Robertson, Wilhelmina H. A. M. Mulders
Summary: This study examines the impact of peripheral deafferentation on the central nervous system in the adult auditory system, focusing on the functional connectivity between the prefrontal cortex and MGN. Results suggest a compensatory mechanism after cochlear trauma to increase sensory gating and prevent altered activity from reaching the cortex.
Article
Biochemistry & Molecular Biology
Daniel A. N. Barbosa, Fiene Marie Kuijper, Jeffrey Duda, Allan R. Wang, Samuel C. D. Cartmell, Sabir Saluja, Tricia Cunningham, Rajat S. Shivacharan, Mahendra T. Bhati, Debra L. Safer, James D. Lock, Robert C. Malenka, Ricardo De Oliveira-Souza, Nolan R. Williams, Murray Grossman, James C. Gee, Jennifer A. McNab, Cara Bohon, Casey H. Halpern
Summary: This study revealed aberrations in the vmPFC-NAc shell circuit in obesity and explored the potential of modulating this circuit to restore control over eating behavior in obese individuals.
MOLECULAR PSYCHIATRY
(2022)
Review
Behavioral Sciences
Andrew Westbrook, Michael J. Frank, Roshan Cools
Summary: Dopamine plays a positive role in cognitive control, affecting both cognitive control capacity and cognitive motivation. Striatal dopamine may enhance control by increasing sensitivity to the costs and benefits of cognitive effort, shaping competition between controlled and prepotent actions. Differing cost-benefit tradeoffs mediated by dopamine signaling in distinct cortico-striatal subregions may reconcile conflicting findings on the impact of dopamine on cognitive control.
TRENDS IN COGNITIVE SCIENCES
(2021)
Article
Neurosciences
Debabrata Hazra, Satoshi Yoshinaga, Keitaro Yoshida, Norio Takata, Kenji F. Tanaka, Ken-ichiro Kubo, Kazunori Nakajima
Summary: This study investigates the effects of activating excitatory neurons in the superficial layers of the prefrontal cortex in a rhythmic or nonrhythmic pattern on cognitive function in mice. The results showed that rhythmic activation enhanced spatial working memory and social recognition, while nonrhythmic activation had no significant effect. This suggests that the pattern of activation plays a crucial role in cognitive enhancement.
Article
Biochemistry & Molecular Biology
Anna Terem, Yonatan Fatal, Noa Peretz-Rivlin, Hagit Turm, Shahar Shohat Koren, Danny Kitsberg, Reut Ashwal-Fluss, Diptendu Mukherjee, Naomi Habib, Ami Citri
Summary: The claustral neurons projecting to the frontal cortex can inhibit oral fentanyl self-administration in mice. Fentanyl transcriptionally activates these neurons, while optogenetic stimulation of these neurons can decrease fentanyl consumption. Inhibition of these neurons can increase fentanyl bout consumption and enhance the representation of fentanyl experience in the frontal cortex.
Article
Neurosciences
Johanna K. K. Kostka, Ileana L. L. Hanganu-Opatz
Summary: Cognitive processing in neonatal mice relies on the functional refinement of the limbic circuitry, with early olfactory processing playing a crucial role in shaping activity within these circuits. Through in vivo recordings and manipulations of mitral/tufted cells in the olfactory bulb, researchers found that the neonatal olfactory bulb synchronizes the limbic circuitry and drives activity in the lateral entorhinal cortex, hippocampus, and prefrontal cortex. This suggests that the olfactory bulb plays a significant role in the communication within limbic circuits during neonatal development.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Clinical Neurology
Rebecca Drachman, Lejla Colic, Anjali Sankar, Linda Spencer, Danielle A. Goldman, Luca M. Villa, Jihoon A. Kim, Maria A. Oquendo, Brian Pittman, Hilary P. Blumberg
Summary: This study aimed to investigate the brain-based distinctions between aggression and impulsivity in Bipolar Disorder (BD) and their associations with risk factors, symptoms, and suicide thoughts and behaviors. The findings revealed elevated aggression and impulsivity in BD, which were associated with childhood maltreatment, depression, substance use disorders, and suicide attempts. The study suggests that these behavioral constructs are associated with specific brain regions and can be targeted for prevention.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Behavioral Sciences
Owen Y. Chao, Susanne Nikolaus, Yi-Mei Yang, Joseph P. Huston
Summary: This review summarizes current studies on recognition memory in rodents, indicating that neuronal circuits connected to the medial prefrontal cortex and hippocampus play important roles in the recognition memory of objects and places.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Takahiro Soshi, Michael Andersson, Toshikazu Kawagoe, Shu Nishiguchi, Minoru Yamada, Yuki Otsuka, Ryusuke Nakai, Nobuhito Abe, Adibah Aslah, Tomohiko Igasaki, Kaoru Sekiyama
Summary: This study found that exercise intervention has positive effects on older adults' brain structures and function, including increased gray matter volume and/or thickness in certain prefrontal areas, as well as the association between increased middle frontal sulcus volume and cognitive improvement. Additionally, there were different changes in prefrontal functional connectivity between the intervention and control groups, which were related to maintaining cognitive performance.
Article
Neurosciences
Ileana L. Hanganu-Opatz, Simon J. B. Butt, Simon Hippenmeyer, Natalia V. De Marco Garcia, Jessica A. Cardin, Bradley Voytek, Alysson R. Muotri
Summary: This review summarizes recent research on the development of the mammalian neocortex, from genetic determination in neural stem cells to the dynamic role of specific neuronal populations in the earliest circuits of the neocortex, and how they contribute to emergent function and cognition. The perspective across species is imperative when investigating the dysfunction of early neocortical circuits in neurodevelopmental disorders, in order to identify targets for therapeutic intervention.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
Nahoko Kuga, Reimi Abe, Kotomi Takano, Yuji Ikegaya, Takuya Sasaki
Summary: The medial prefrontal cortex and amygdala play important roles in regulating social behavior, but their specific neurophysiological mechanisms are still unclear. This study recorded local field potentials (LFPs) from these brain regions in male mice engaged in social behavior. It was found that both the medial prefrontal cortex and amygdala showed changes in oscillation power when mice attended to another target mouse. Manipulating specific neural activity patterns in these regions restored social interaction behavior in socially deficient mice, providing insights into the underlying neurophysiological basis of social behavioral deficits.
Article
Neurosciences
Paul Alexander Bloom, Michelle VanTieghem, Laurel Gabard-Durnam, Dylan G. Gee, Jessica Flannery, Christina Caldera, Bonnie Goff, Eva H. Telzer, Kathryn L. Humphreys, Dominic S. Fareri, Mor Shapiro, Sameah Algharazi, Niall Bolger, Mariam Aly, Nim Tottenham
Summary: The amygdala and its connections with the medial prefrontal cortex (mPFC) play important roles in the development of emotional processes. This study used multiverse analyses to examine the robustness of task-based amygdala-mPFC function findings to analytical choices and found that age-related changes in amygdala reactivity were more robust than task-evoked amygdala-mPFC functional connectivity. The findings highlight the challenges in estimating developmental changes and the value of multiverse approaches in assessing the robustness of results in developmental neuroimaging.
HUMAN BRAIN MAPPING
(2022)
Article
Multidisciplinary Sciences
Tanja Muller, Miriam C. Klein-Flugge, Sanjay G. Manohar, Masud Husain, Matthew A. J. Apps
Summary: Studies show that fatigue can affect people's willingness to persist in demanding tasks. Using computational modeling, researchers have revealed the dynamic impact of fatigue on effort-based choices and identified the neural mechanisms underlying such computations.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Sarah L. Aghjayan, Chelsea M. Stillman, Nermeen E. El Nokali, Jennifer C. Watt, Emily A. Richards, Michele A. Bertocci, Kirk I. Erickson, Dana L. Rofey
Summary: The study found that overweight and obesity in adolescents are associated with reductions in blood flow to specific brain regions rather than having a global impact on cerebral blood flow.
Article
Geriatrics & Gerontology
Lijuan Huo, Xinyi Zhu, Zhiwei Zheng, Jialing Ma, Zhuoya Ma, Wenjun Gui, Juan Li
Summary: This meta-analysis found significant effects of tDCS on improving episodic memory functions in older adults, particularly showing memory improvements at both immediate poststimulation and long-term follow-up assessments. The results suggest that tDCS protocols with shorter durations, bilateral stimulation, or larger stimulation areas may enhance episodic memory performance in older adults.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2021)
Article
Neurosciences
Takatoshi Hikida, Makiko Morita, Mahomi Kuroiwa, Tom Macpherson, Takahide Shuto, Naoki Sotogaku, Minae Niwa, Akira Sawa, Akinori Nishi
NEUROSCIENCE RESEARCH
(2020)
Review
Clinical Neurology
Tom Macpherson, Takatoshi Hikida
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2019)
Article
Behavioral Sciences
Koshi Murata, Tomoki Kinoshita, Yugo Fukazawa, Kenta Kobayashi, Akihiro Yamanaka, Takatoshi Hikida, Hiroyuki Manabe, Masahiro Yamaguchi
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2019)
Letter
Clinical Neurology
Tom Macpherson, Takatoshi Hikida
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2019)
Article
Neurosciences
Norifumi Shioda, Yoshiki Imai, Yasushi Yabuki, Wataru Sugimoto, Kouya Yamaguchi, Yanyan Wang, Takatoshi Hikida, IbToshikuni Sasaoka, EMic Hihiro Mieda, Kohji Fukunaga
JOURNAL OF NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Tom Macpherson, Hiroyuki Mizoguchi, Akihiro Yamanaka, Takatoshi Hikida
NEUROCHEMISTRY INTERNATIONAL
(2019)
Article
Biochemistry & Molecular Biology
Qiuyi Wang, Kimiko Shimizu, Kanako Maehata, Yue Pan, Koki Sakurai, Takatoshi Hikida, Yoshitaka Fukada, Toshifumi Takao
JOURNAL OF LIPID RESEARCH
(2020)
Article
Multidisciplinary Sciences
Takatoshi Hikida, Shuhei Yao, Tom Macpherson, Ayumi Fukakusa, Makiko Morita, Haruhide Kimura, Keisuke Hirai, Tatsuya Ando, Hiroyoshi Toyoshiba, Akira Sawa
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Nae Saito, Kazuki Tainaka, Tom Macpherson, Takatoshi Hikida, Shun Yamaguchi, Toshikuni Sasaoka
NEUROSCIENCE RESEARCH
(2020)
Article
Neurosciences
Tadaaki Nishioka, Kosuke Hamaguchi, Satoshi Yawata, Takatoshi Hikida, Dai Watanabe
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2020)
Article
Psychiatry
Yukiko Hamasaki, Takao Nakayama, Takatoshi Hikida, Toshiya Murai
Summary: This study retrospectively identified specific psycho-behavioral characteristics in childhood associated with later development of schizophrenia through guardian reports. The algorithm developed based on CBCL scores showed moderate accuracy in predicting later schizophrenia, suggesting the potential utility of early childhood characteristics in identifying individuals at risk for developing schizophrenia.
Correction
Biochemistry & Molecular Biology
Hiroyuki Yatsuka, Kazumasa Hada, Hiroshi Shiraishi, Ryohei Umeda, Ikuko Morisaki, Hirotaro Urushibata, Nobuyuki Shimizu, Wulan Apridita Sebastian, Takatoshi Hikida, Tohru Ishitani, Reiko Hanada, Tatsuo Shimada, Kenichi Kimoto, Toshiaki Kubota, Toshikatsu Hanada
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Psychology, Developmental
Yukiko Hamasaki, Nancy Pionnie-Dax, Geraldine Dorard, Nicolas Tajan, Takatoshi Hikida
Summary: It was found that the severity of hikikomori during adolescence is related to factors such as anxiety/depression, somatic symptoms, lack of communication between parents, and overuse of the Internet. This can help in identifying individuals at risk of developing hikikomori.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2021)
Article
Multidisciplinary Sciences
Madoka Anan, Ryoko Higa, Kenshiro Shikano, Masahito Shide, Akinobu Soda, Magdeline E. Carrasco Apolinario, Kenji Mori, Toshitaka Shin, Mikiya Miyazato, Hiromitsu Mimata, Takatoshi Hikida, Toshikatsu Hanada, Kazuwa Nakao, Kenji Kangawa, Reiko Hanada
Article
Multidisciplinary Sciences
Takashi Kozuka, Yoshihiro Omori, Satoshi Watanabe, Etsuko Tarusawa, Haruka Yamamoto, Taro Chaya, Mayu Furuhashi, Makiko Morita, Tetsuya Sato, Shinichi Hirose, Yasuyuki Ohkawa, Yumiko Yoshimura, Takatoshi Hikida, Takahisa Furukawa
SCIENTIFIC REPORTS
(2019)