Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 8, Pages 4768-4771Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.03379-12
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Funding
- Wellcome Trust
- Medical Research Council of the United Kingdom
- National Institutes of Health [R01 GM080533-06]
- National Health and Medical Research Council Australia
- Alborada Trust
- RAPIDD program of the Science & Technology Directorate, Department of Homeland Security
- Fogarty International Center, National Institutes of Health
- DEFRA [VT0105]
- HEFCE under the Veterinary Training and Research Initiative
- MRC [G0801822] Funding Source: UKRI
- Medical Research Council [G0801822] Funding Source: researchfish
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Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naive horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites.
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