Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 17, Pages 9933-9938Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01283-13
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Funding
- Austrian Science Fund FWF [P22914-B13]
- Austrian Science Fund (FWF) [P 22914] Funding Source: researchfish
- Austrian Science Fund (FWF) [P22914] Funding Source: Austrian Science Fund (FWF)
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The flavivirus fusion protein E contains a stem region which is hypothesized to be crucial for driving fusion. This sequence element connects the ectodomain to the membrane anchor, and its structure in the trimeric postfusion conformation is still poorly defined. Using E trimers of tick-borne encephalitis virus with stem truncations of different lengths, we show that the N-terminal part of the stem increases trimer stability and also modulates the trimer structure outside the stem interaction site.
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