Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 23, Pages 13081-13084Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01741-12
Keywords
-
Categories
Funding
- Fondo de Investigacion Sanitaria (FIS) project from the Instituto de Salud Carlos III [PI09/00278]
Ask authors/readers for more resources
Several factors are involved in the control of HIV transcription/replication, including epigenetic modifications at the promoter level. Analysis of the HIV long terminal repeat (LTR) methylation status in infected patients controlling viremia is scarce. Herein, we show a higher degree of DNA methylation in the 5'-LTR of long-term nonprogressor and elite controller (LTNP/EC) versus progressor patients and a positive correlation with time of infection, indicating a certain contribution of HIV LTR silencing in reducing the number of replicating viruses which may account for a delayed progression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available