Uncommon Pathways of Immune Escape Attenuate HIV-1 Integrase Replication Capacity

CTL-Mediated Selective Pressure Influences Dynamic Evolution and Pathogenic Functions of HIV-1 Nef

(2014) T. Ueno et al.   JOURNAL OF IMMUNOLOGY

Raltegravir: the first HIV-1 integrase strand transfer inhibitor in the HIV armamentarium

(2011) Bach-Yen T. Nguyen et al.   Annals of the New York Academy of Sciences

Structural insights into the retroviral DNA integration apparatus

(2011) Peter Cherepanov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts To Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes

(2011) C.-A. M. Almeida et al.   JOURNAL OF IMMUNOLOGY

Definition of the viral targets of protective HIV-1-specific T cell responses

(2011) Beatriz Mothe et al.   Journal of Translational Medicine

A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase

(2011) Trevor Hinkley et al.   NATURE GENETICS

Progression to AIDS in South Africa Is Associated with both Reverting and Compensatory Viral Mutations

(2011) Kuan-Hsiang Gary Huang et al.   PLoS One

Viral suppression of multiple escape mutants by de novo CD8+ T cell responses in a human immunodeficiency virus-1 Infected elite suppressor

(2011) Karen A O'Connell et al.   Retrovirology

Structural biology of retroviral DNA integration

(2011) Xiang Li et al.   VIROLOGY

The Sydney Blood Bank Cohort: implications for viral fitness as a cause of elite control

(2011) John Zaunders et al.   Current Opinion in HIV and AIDS

HIV-1 replicative fitness in elite controllers

(2011) Michael A Lobritz et al.   Current Opinion in HIV and AIDS

Effect of Raltegravir Resistance Mutations in HIV-1 Integrase on Viral Fitness

(2010) Zixin Hu et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Reduced Replication Capacity of NL4-3 Recombinant Viruses Encoding Reverse Transcriptase–Integrase Sequences From HIV-1 Elite Controllers

(2010) Zabrina L Brumme et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Integrase inhibitors in the treatment of HIV-1 infection

(2010) W. G. Powderly   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Long-Term Control of HIV-1 in Hemophiliacs Carrying Slow-Progressing Allele HLA-B*5101

(2010) Y. Kawashima et al.   JOURNAL OF VIROLOGY

Gag-Protease-Mediated Replication Capacity in HIV-1 Subtype C Chronic Infection: Associations with HLA Type and Clinical Parameters

(2010) Jaclyn K. Wright et al.   JOURNAL OF VIROLOGY

Early Selection in Gag by Protective HLA Alleles Contributes to Reduced HIV-1 Replication Capacity That May Be Largely Compensated for in Chronic Infection

(2010) M. A. Brockman et al.   JOURNAL OF VIROLOGY

Efficacious Early Antiviral Activity of HIV Gag- and Pol-Specific HLA-B*2705-Restricted CD8+T Cells

(2010) Rebecca P. Payne et al.   JOURNAL OF VIROLOGY

Impaired Replication Capacity of Acute/Early Viruses in Persons Who Become HIV Controllers

(2010) T. Miura et al.   JOURNAL OF VIROLOGY

The mechanism of retroviral integration from X-ray structures of its key intermediates

(2010) Goedele N. Maertens et al.   NATURE

The HIV-1 integrase genotype strongly predicts raltegravir susceptibility but not viral fitness of primary virus isolates

(2009) Maria José Buzón et al.   AIDS

Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses during Primary Infection Are Major Determinants of the Viral Set Point and Loss of CD4+ T Cells

(2009) H. Streeck et al.   JOURNAL OF VIROLOGY

HLA-Associated Immune Escape Pathways in HIV-1 Subtype B Gag, Pol and Nef Proteins

(2009) Zabrina L. Brumme et al.   PLoS One

Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response

(2009) Ryan M. Troyer et al.   PLoS Pathogens

Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients

(2008) Paul A. Goepfert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load

(2008) C. M. Rousseau et al.   JOURNAL OF VIROLOGY

HLA-Associated Alterations in Replication Capacity of Chimeric NL4-3 Viruses Carrying gag-protease from Elite Controllers of Human Immunodeficiency Virus Type 1

(2008) T. Miura et al.   JOURNAL OF VIROLOGY

Reduced Viral Replication Capacity of Human Immunodeficiency Virus Type 1 Subtype C Caused by Cytotoxic-T-Lymphocyte Escape Mutations in HLA-B57 Epitopes of Capsid Protein

(2008) C. L. Boutwell et al.   JOURNAL OF VIROLOGY

Functional Consequences of Human Immunodeficiency Virus Escape from an HLA-B*13-Restricted CD8+ T-Cell Epitope in p1 Gag Protein

(2008) J. G. Prado et al.   JOURNAL OF VIROLOGY

Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection

(2008) Z. L. Brumme et al.   JOURNAL OF VIROLOGY

Natural variation of HIV-1 group M integrase: Implications for a new class of antiretroviral inhibitors

(2008) Soo-Yon Rhee et al.   Retrovirology

Transmission of HIV-1 CTL Escape Variants Provides HLA-Mismatched Recipients with a Survival Advantage

(2008) Denis R. Chopera et al.   PLoS Pathogens