Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 24, Pages 13779-13784Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01625-12
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Funding
- Academy of Finland [129774, 138388]
- National Graduate School in NanoScience
- National Graduate School in Informational and Structural Biology
- Academy of Finland (AKA) [138388, 129774, 138388, 129774] Funding Source: Academy of Finland (AKA)
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Canine parvovirus (CPV) infection leads to reorganization of nuclear proteinaceous subcompartments. Our studies showed that virus infection causes a time-dependent increase in the amount of viral nonstructural protein NS1 mRNA. Fluorescence recovery after photobleaching showed that the recovery kinetics of nuclear transcription-associated proteins, TATA binding protein (TBP), transcription factor IIB (TFIIB), and poly(A) binding protein nuclear 1 (PABPN1) were different in infected and noninfected cells, pointing to virus-induced alterations in binding dynamics of these proteins.
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