Article
Virology
Barkha Ramnani, Praveen Manivannan, Sarah Jaggernauth, Krishnamurthy Malathi
Summary: Host response to viral infection involves production of IFN and induction of interferon-stimulated genes, including the key antiviral effector OAS/RNase L pathway. ABCE1 transporter, identified as an inhibitor of RNase L, regulates RNase L activity and autophagy during viral infections, potentially affecting antiviral effects.
Review
Cell Biology
Tong Chen, Shaoyu Tu, Ling Ding, Meilin Jin, Huanchun Chen, Hongbo Zhou
Summary: Autophagy is a cellular process that degrades virus particles and components during a viral infection. However, viruses have evolved various strategies to subvert autophagy and counteract cellular antiviral responses.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Cell Biology
Gloria Stoyanova, Sidra Jabeen, Joselyn Landazuri Vinueza, Sounak Ghosh Roy, Richard A. Lockshin, Zahra Zakeri
Summary: This study found that pretreating MDCK cells with atorvastatin and other autophagy inhibitors can suppress ZIKV replication by reducing the number of LD and cholesterol levels. Additionally, bafilomycin A1 inhibits viral expression by blocking cholesterol esterification.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Li Chen, Limin Yang, Yingyu Li, Tianrun Liu, Bolun Yang, Lei Liu, Rui Wu
Summary: The interaction between autophagy and inflammation plays a crucial role in viral infections, and understanding their regulatory roles can provide insights and theoretical foundations for disease prevention, treatment, and drug development.
Article
Immunology
Panpan Hou, Yuxin Lin, Zibo Li, Ruiqing Lu, Yicheng Wang, Tian Tian, Penghui Jia, Xi Zhang, Liu Cao, Zhongwei Zhou, Chunmei Li, Jieruo Gu, Deyin Guo
Summary: CCDC50, a newly identified autophagy receptor, plays a critical role in regulating STING-directed type I IFN signaling and immune response. Deficiency in CCDC50 may lead to overactivation of immune responses in SLE patients and enhanced immune response in HSV-1 infections.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Cell Biology
James M. Burke
Summary: In response to viral infection, mammalian cells activate innate immune pathways to inhibit viral gene expression and promote the assembly of specific ribonucleoprotein complexes, thereby enhancing cell survival and antiviral signaling.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Article
Veterinary Sciences
Xiujuan Zhang, Peipei Ma, Ting Shao, Yingli Xiong, Qian Du, Songbiao Chen, Bichen Miao, Xuezhi Zhang, Xiaoya Wang, Yong Huang, Dewen Tong
Summary: Porcine parvovirus infection induces autophagy to promote viral replication by inhibiting the activation of mTORC1 through the AMPK/Raptor pathway.
VETERINARY RESEARCH
(2022)
Article
Cell Biology
Yanxian Ren, Pengfei Yang, Chenghao Li, Wen-an Wang, Tianyi Zhang, Jin Li, Haining Li, Chunlu Dong, Wenbo Meng, Heng Zhou
Summary: Radiotherapy is an important cancer treatment strategy that causes DNA damage in tumor cells either directly or indirectly. Autophagy is a physiological process linked to DNA damage. Mitophagy, a form of autophagy, increases ionizing radiation-induced DNA damage by downregulating or overexpressing key mitophagy proteins Parkin and BNIP3. Enhancing the basal level of mitophagy in conjunction with X-ray irradiation can potentially diminish cell cycle arrest at the G2/M phase, substantially elevate the accumulation of γ-H2AX, 53BP1, and PARP1 foci within the nucleus, augment DNA damage, and facilitate the demise of tumor cells. This approach prolongs the survival of melanoma-bearing mice and offers a therapeutic approach for enhancing the therapeutic effectiveness of radiotherapy.
CELL DEATH DISCOVERY
(2023)
Review
Plant Sciences
Ivana Jovanovic, Nicole Frantova, Jan Zouhar
Summary: The plant endomembrane system plays a crucial role in plant growth and development, as well as in responses to abiotic and biotic stresses. Plant viruses remodel this system to create replication compartments and evade host defenses. Recent research has revealed that plant antiviral immunity involves receptor-like kinases and selective autophagy, highlighting the complex interplay between viral components and the plant endomembrane-associated pathways.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Cell Biology
Cheng Xiang Foo, Stacey Bartlett, Katharina Ronacher
Summary: This review provides an overview of the role of oxysterols in controlling intracellular bacterial growth, viral entry into host cells, and replication, as well as their potential as drug targets for infectious and inflammatory diseases.
Article
Multidisciplinary Sciences
Lavanya Manjunath, Sunwoo Oh, Pedro Ortega, Alexis Bouin, Elodie Bournique, Ambrocio Sanchez, Pia Moller Martensen, Ashley A. Auerbach, Jordan T. Becker, Marcus Seldin, Reuben S. Harris, Bert L. Semler, Remi Buisson
Summary: The study shows that APOBEC3B inhibits viral replication by stimulating protein kinase R, causing translational shut down and stress granule formation independently of its cytidine deaminase activity. APOBEC3B forms a complex with PABPC1 to stimulate protein kinase R and counteract the suppressive effect of ADAR1. APOBEC3B also protects mRNA associated with stress granules from RNAse L-induced RNA cleavage during viral infection.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Maimoona Shahid Bhutta, Elisa S. Gallo, Ronen Borenstein
Summary: Viral pathogens often manipulate host cell regulatory and signaling pathways to create an optimal environment for their growth and survival. AMPK plays a significant role in infection modulation, with viruses altering AMPK signaling activity to facilitate or inhibit viral replication. Understanding the regulation of AMPK signaling following infection can aid in developing more effective therapeutic strategies against viral infectious diseases, including the COVID-19 pandemic.
Review
Biochemistry & Molecular Biology
Shailendra Pratap Singh, Salomon Amar, Pinky Gehlot, Sanjib K. Patra, Navjot Kanwar, Abhinav Kanwal
Summary: Mitochondria are crucial organelles in regulating intracellular events, which can be altered by viruses to induce cellular stress and promote viral proliferation. Autophagy plays a key role in SARS-COV2-mediated COVID-19 and serves as a potential target for anti-viral therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Emergency Medicine
Renana Gelernter, Nimrod Ophir, Michael Goldman, Zipora Lazarovitch, Shirly Gamsu, Adi Oren-Amit, Rachel Breitbart, Shiri Barkan Perl, Eran Kozer, Ilan Youngster
Summary: This study compared the antipyretic effects of ibuprofen in febrile children with serious bacterial infections and presumed viral infections. The results showed that ibuprofen administration did not significantly reduce fever in children with serious bacterial infections.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Immunology
Cathleen R. Carlin
Summary: This review article provides an overview of the structure, function, and therapeutic importance of EGFR in epithelial carcinomas. It compares different trafficking pathways triggered by ligand binding and cellular stresses, and explores the role of EGFR in viral cell entry and replication. It also discusses the emerging role of EGFR signaling in innate immunity to viral infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)