Journal
JOURNAL OF VIROLOGY
Volume 85, Issue 10, Pages 4898-4909Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02525-10
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Funding
- Department of Homeland Security/National Biodefense and Countermeasures Center [RSRD-05-00378]
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Variola, the causative agent of smallpox, and the related monkeypox virus are both select agents that, if purposefully released, would cause public panic and social disruption. For this reason research continues in the areas of animal model and therapeutic development. Orthopoxviruses show a widely varying degree of host specificity, making development of accurate animal models difficult. In this paper, we demonstrate a novel respiratory infection technique that resulted in classic orthopox disease in nonhuman primates and takes the field of research one step closer to a better animal model.
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