Conserved GXXXG- and S/T-Like Motifs in the Transmembrane Domains of NS4B Protein Are Required for Hepatitis C Virus Replication

New opportunities in anti-hepatitis C virus drug discovery: Targeting NS4B

(2011) Roopa Rai et al.   ANTIVIRAL RESEARCH

Biochemical Characterization of Recombinant Hepatitis C Virus Nonstructural Protein 4B: Evidence for ATP/GTP Hydrolysis and Adenylate Kinase Activity†

(2009) Aaron A. Thompson et al.   BIOCHEMISTRY

An Amphipathic  -Helix at the C Terminus of Hepatitis C Virus Nonstructural Protein 4B Mediates Membrane Association

(2009) J. Gouttenoire et al.   JOURNAL OF VIROLOGY

Identification of a Novel Determinant for Membrane Association in Hepatitis C Virus Nonstructural Protein 4B

(2009) J. Gouttenoire et al.   JOURNAL OF VIROLOGY

The Structure of a Receptor with Two Associating Transmembrane Domains on the Cell Surface: Integrin αIIbβ3

(2009) Jieqing Zhu et al.   MOLECULAR CELL

Consensus motif for integrin transmembrane helix association

(2009) B. W. Berger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction and conformational dynamics of membrane-spanning protein helices

(2009) Dieter Langosch et al.   PROTEIN SCIENCE

Formation and function of hepatitis C virus replication complexes require residues in the carboxy-terminal domain of NS4B protein

(2009) Jason Aligo et al.   VIROLOGY

Endocytic Rab proteins are required for hepatitis C virus replication complex formation

(2009) David Manna et al.   VIROLOGY

Hepatitis C virus NS4B carboxy terminal domain is a membrane binding domain

(2009) Jolanda MP Liefhebber et al.   Virology Journal

Compensatory mutations in NS3 and NS5A proteins enhance the virus production capability of hepatitis C reporter virus

(2009) Qingxia Han et al.   VIRUS RESEARCH

Production of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing Mutations

(2009) Thomas Pietschmann et al.   PLoS Pathogens

The Hepatitis C Virus NS4B Protein Can trans-Complement Viral RNA Replication and Modulates Production of Infectious Virus

(2008) D. M. Jones et al.   JOURNAL OF VIROLOGY

A Genetic Interaction between Hepatitis C Virus NS4B and NS3 Is Important for RNA Replication

(2008) A. M. Paredes et al.   JOURNAL OF VIROLOGY

NS3 Helicase Domains Involved in Infectious Intracellular Hepatitis C Virus Particle Assembly

(2008) Y. Ma et al.   JOURNAL OF VIROLOGY

Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles

(2008) T. Masaki et al.   JOURNAL OF VIROLOGY

Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis

(2008) Shirit Einav et al.   NATURE BIOTECHNOLOGY

Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus

(2008) R. S. Russell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly

(2008) Nicole Appel et al.   PLoS Pathogens

Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein

(2008) Timothy L. Tellinghuisen et al.   PLoS Pathogens