Article
Immunology
Mette Ratzer Freytag, Sofie Eg Jorgensen, Michelle Molgaard Thomsen, Ali Al-Mousawi, Alon Schneider Hait, David Olagnier, Jakob T. Bay, Marie Helleberg, Trine H. Mogensen
Summary: This study describes a 19-year-old woman with systemic HSV-1 infection and HLH, as well as a fatal course of neonatal herpesvirus infection postpartum. Investigation showed impaired antiviral responses in the mother's cells, potentially caused by variants in CASP8 or other noncoding regions of the genome.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Jie Wang, Kun-Te Shang, Qiong-Hong Ma, Zhao-Ying Dong, Yi-Hong Chen, Yu-Feng Yao
Summary: This study aimed to determine whether HSV-1 can be transmitted through TNTs and to investigate the effect of inhibiting the Arp2/3 complex on the intercellular transmission of HSV-1. The results showed that HSV-1 can be transmitted through TNTs and that inhibiting the Arp2/3 complex reduces the number of TNTs and the spread of HSV-1. This finding provides new insights into the transmission mode of HSV-1 and suggests a potential new antiviral target.
Review
Oncology
Hayle Scanlan, Zachary Coffman, Jeffrey Bettencourt, Timothy Shipley, Debra E. Bramblett
Summary: This review provides an overview of HSV-1 as an oncolytic virus candidate and the genomic organization of T-VEC. The advantages and limitations of T-VEC compared to other HSV-1 oncolytic virus variants currently in clinical trials are discussed. Additionally, future directions for the use of HSV-1 oncolytic viruses as cancer therapy are explored.
FRONTIERS IN ONCOLOGY
(2022)
Review
Microbiology
Hongyan Guo, Heather S. Koehler, Richard D. Dix, Edward S. Mocarski
Summary: HSV1 is a common human pathogen that can cause oral and ocular diseases. Host immune mechanisms and cell death pathways play important roles in controlling HSV1 infection, while the virus has evolved strategies to evade host cell death.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Ye Liu, Qiao You, Fang Zhang, Deyan Chen, Zhenping Huang, Zhiwei Wu
Summary: Harringtonine (HT) significantly inhibited HSV-1 infection and two ACV-resistant strains by mainly targeting HVEM and reducing the early stage of HSV-1 infection. The study demonstrated that HT could be a promising therapeutic candidate for mitigating HSV-1-induced pathogenesis.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Austin M. Jeffries, Alexander J. Suptela, Ian Marriott
Summary: This study found that ZBP1 serves as a restriction factor for HSV-1 infection and is associated with the induction of both necroptotic and apoptotic cell death pathways in primary murine astrocytes.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Pu Huang, Xu Wang, Mengyue Lei, Ying Ma, Hongli Chen, Jing Sun, Yunzhang Hu, Jiandong Shi
Summary: This study investigates the metabolic interaction between host cells and HSV-1. By analyzing the metabolic profiles in HSV-1-infected lung fibroblasts, the researchers found that HSV-1 induces metabolic reprogramming in host cells to promote or resist viral replication. They confirmed that the addition of the tryptophan metabolite kynurenine promotes viral replication, while the addition of 25-Hydroxycholesterol inhibits replication. Additionally, HSV-1 replication was enhanced in choline metabolic rate-limiting enzyme-deficient mouse macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Jing-yu Weng, Xin-xing Chen, Xiao-hua Wang, Hui-er Ye, Yan-ping Wu, Wan-yang Sun, Lei Liang, Wen-jun Duan, Hiroshi Kurihara, Feng Huang, Xin-xin Sun, Shu-hua Ou-Yang, Rong-rong He, Yi-fang Li
Summary: Psychological stress increases susceptibility to HSV-1 infection, and the underlying molecular mechanisms are unknown. This study explored the antiviral effect of rosmarinic acid (RA) and demonstrated that RA could decrease stress-augmented mortality and reduce symptoms in HSV-1-infected mice. In vitro, RA increased cell viability and inhibited stress-induced elevation of viral proteins and genes. The study revealed the critical role of lipid peroxidation in stress-induced HSV-1 susceptibility and suggested the potential of RA as an effective intervention in anti-HSV-1 therapy.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Multidisciplinary Sciences
Elizabeth B. Draganova, Ekaterina E. Heldwein
Summary: Herpesviruses infect a majority of the human population, establishing lifelong latent infections with no cure, and periodic viral reactivation spreads infection while causing disease states that are particularly harmful in the immunocompromised. The viral replication and spread of infection rely on the nuclear egress complex (NEC), which helps translocate viral capsids and mature them into infectious virions. Peptides derived from the UL25 capsid protein have been shown to inhibit the membrane-budding activity of the NEC, providing a potential new avenue for developing inhibitors against herpesvirus replication.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Yumiko Asanuma, Hironobu Ishimaru, Tetsuko Sato, Takenobu Yamamoto, Yumi Aoyama
Summary: This study established a mouse model of dry skin caused by sweating disturbance induced by HSV-1 infection and determined the impact of HSV-1 infection on sweat gland function.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Ines Ripa, Sabina Andreu, Jose Antonio Lopez-Guerrero, Raquel Bello-Morales
Summary: The article discusses the role of the HSV-1 viral protein ICP34.5 in controlling cellular antiviral responses and debates its controversial functions such as autophagy inhibition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pathology
Melissa Krystel-Whittemore, May P. Chan, Sara C. Shalin, Kenan J. Sauder, Amy Hudson, Ruth K. Foreman, Mai P. Hoang, Jeoffry B. Brennick, Shaofeng Yan, Rosalynn M. Nazarian
Summary: This study presents the first known report of herpes virus infecting deep stromal cells of the dermis, highlighting the importance of considering cutaneous stromal herpes in patients with atypical clinical lesions, especially when immunocompromised. Establishing the correct diagnosis is crucial for initiating therapy.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fanghui Ren, Ryo Narita, Ahmad S. Rashidi, Stefanie Fruhwurth, Zongliang Gao, Rasmus O. Bak, Martin K. Thomsen, Georges M. G. M. Verjans, Line S. Reinert, Soren R. Paludan
Summary: Neurotropic viruses such as herpes simplex virus (HSV) can infect neurons and cause severe diseases. HSV-induced neuronal cell death is mediated by gasdermin E (GSDME) and involves endoplasmic reticulum stress, caspase activation, and mitochondria-dependent apoptosis. The necrotic neurons release alarmins, triggering inflammatory responses in microglia.
Review
Virology
Lena Feige, Luca M. Zaeck, Julia Sehl-Ewert, Stefan Finke, Herve Bourhy
Summary: The environment of the central nervous system plays a dual role in viral infections, restricting the infectious route for viral pathogens while providing a beneficial neural environment for viruses after CNS entry. Different viruses like HSV and RABV use retrograde transport along peripheral nerves to enter the CNS, with each virus causing distinct outcomes once inside the CNS parenchyma.
Article
Microbiology
Lulia Koujah, Krishnaraju Madavaraju, Alex M. Agelidis, Chandrashekhar D. Patil, Deepak Shukla
Summary: The study identified a novel regulatory role of HPSE as a key driver of beta-catenin signaling in HSV-1 infection, which disrupts cellular homeostasis and promotes viral replication. Inhibition of this pathway showed promise as a potential antiviral strategy against multiple strains of HSV-1.
Article
Medicine, General & Internal
D. W. Kimberlin, P. M. Jester, P. J. Sanchez, A. Ahmed, R. Arav-Boger, M. G. Michaels, N. Ashouri, J. A. Englund, B. Estrada, R. F. Jacobs, J. R. Romero, S. K. Sood, M. S. Whitworth, M. J. Abzug, M. T. Caserta, S. Fowler, J. Lujan-Zilbermann, G. A. Storch, R. L. DeBiasi, J. -Y. Han, A. Palmer, L. B. Weiner, J. A. Bocchini, P. H. Dennehy, A. Finn, P. D. Griffiths, S. Luck, K. Gutierrez, N. Halasa, J. Homans, A. L. Shane, M. Sharland, K. Simonsen, J. A. Vanchiere, C. R. Woods, D. L. Sabo, I. Aban, H. Kuo, S. H. James, M. N. Prichard, J. Griffin, D. Giles, E. P. Acosta, R. J. Whitley
NEW ENGLAND JOURNAL OF MEDICINE
(2015)
Editorial Material
Infectious Diseases
Ciji Arthur, Jared M. Gardner, Jin-Young Han
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2015)
Article
Dermatology
Michael Vanden Oever, Daniel Muldoon, Wendy Mathews, Ron McElmurry, Jakub Tolar
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2016)
Review
Pediatrics
Michael Vanden Oever, Kirk Twaroski, Mark J. Osborn, John E. Wagner, Jakub Tolar
PEDIATRIC RESEARCH
(2018)
Article
Virology
Jin-Young Han, Sara A. Miller, Teresa M. Wolfe, Hoda Pourhassan, Keith R. Jerome
JOURNAL OF VIROLOGY
(2009)
Article
Immunology
Jin-Young Han, David C. Hanson, Sing Sing Way
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2011)
Article
Pediatrics
Karen P. Acker, Katherine Schertz, Erika L. Abramson, Patricia DeLaMora, Christine M. Salvatore, Jin-Young Han
CLINICAL PEDIATRICS
(2020)
Article
Pediatrics
Christine M. Salvatore, Jin-Young Han, Karen P. Acker, Priyanka Tiwari, Jenny Jin, Michael Brandler, Carla Cangemi, Laurie Gordon, Aimee Parow, Jennifer DiPace, Patricia DeLaMora
LANCET CHILD & ADOLESCENT HEALTH
(2020)
Article
Dermatology
M. Vanden Oever, D. Muldoon, W. Mathews, J. Tolar
Summary: Fludarabine influences the production of type VII collagen in RDEB fibroblasts by activating multiple signaling pathways, ultimately leading to increased COL7A1 expression.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Christine T. Styles, Jie Zhou, Katie E. Flight, Jonathan C. Brown, Charlotte Lewis, Xinyu Wang, Michael Vanden Oever, Thomas P. Peacock, Ziyin Wang, Rosie Millns, John S. O'Neill, Alexander Borodavka, Joe Grove, Wendy S. Barclay, John S. Tregoning, Rachel S. Edgar
Summary: The study found that propylene glycol (PG) has strong virucidal activity against a broad range of viruses, including influenza A, SARS-CoV-2, and rotavirus. It can reduce disease burden in mice and efficiently prevent infection by vaporizing PG at levels tolerated by mammals. The research presents PG vapor as a non-toxic airborne virucide that can prevent the transmission of existing and emerging viral pathogens, with immediate implications for public health.
EMBO MOLECULAR MEDICINE
(2023)
Article
Virology
Jin-Young Han, Derek D. Sloan, Martine Aubert, Sara A. Miller, Chung H. Dang, Keith R. Jerome
Article
Immunology
SH Armenian, JY Han, TM Dunaway, JA Church
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2006)
Article
Immunology
DD Sloan, JY Han, TK Sandifer, M Stewart, AJ Hinz, M Yoon, DC Johnson, PG Spear, KR Jerome
JOURNAL OF IMMUNOLOGY
(2006)
