Journal
JOURNAL OF VIROLOGY
Volume 85, Issue 2, Pages 1140-1144Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01362-10
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Funding
- American Cancer Society [RSG-10-060-01]
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The Kaposi's sarcoma-associated herpesvirus (KSHV) G protein-coupled receptor (vGPCR) is a constitutively active, highly angiogenic homologue of the interleukin-8 (IL-8) receptors that signals in part via the cytoplasmic protein tyrosine phosphatase Shp2. We show that vGPCR contains a bona fide immunoreceptor tyrosine-based inhibitory motif (ITIM) that binds and constitutively activates Shp2.
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